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Deep learning has excelled in medical image classification, but its clinical application is limited by poor interpretability. Capsule networks, known for encoding hierarchical relationships and spatial features, show potential in addressing…

Computer Vision and Pattern Recognition · Computer Science 2024-11-05 Xinyu Geng , Jiaming Wang , Jun Xu

Medical images are acquired at high resolutions with large fields of view in order to capture fine-grained features necessary for clinical decision-making. Consequently, training deep learning models on medical images can incur large…

Sparse autoencoders (SAEs) have gained a lot of attention as a promising tool to improve the interpretability of large language models (LLMs) by mapping the complex superposition of polysemantic neurons into monosemantic features and…

Computation and Language · Computer Science 2025-02-19 Gouki Minegishi , Hiroki Furuta , Yusuke Iwasawa , Yutaka Matsuo

Sparse Autoencoders (SAEs) have become an important tool in mechanistic interpretability, helping to analyze internal representations in both Large Language Models (LLMs) and Vision Transformers (ViTs). By decomposing polysemantic…

Machine Learning · Computer Science 2026-05-11 Jakub Stępień , Marcin Mazur , Jacek Tabor , Przemysław Spurek

Sparse Autoencoders (SAEs) can efficiently identify candidate monosemantic features from pretrained neural networks for galaxy morphology. We demonstrate this on Euclid Q1 images using both supervised (Zoobot) and new self-supervised (MAE)…

Instrumentation and Methods for Astrophysics · Physics 2025-11-13 John F. Wu , Michael Walmsley

Many current state-of-the-art models for sequential recommendations are based on transformer architectures. Interpretation and explanation of such black box models is an important research question, as a better understanding of their…

Information Retrieval · Computer Science 2026-02-18 Anton Klenitskiy , Konstantin Polev , Daria Denisova , Alexey Vasilev , Dmitry Simakov , Gleb Gusev

We present Universal Sparse Autoencoders (USAEs), a framework for uncovering and aligning interpretable concepts spanning multiple pretrained deep neural networks. Unlike existing concept-based interpretability methods, which focus on a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Harrish Thasarathan , Julian Forsyth , Thomas Fel , Matthew Kowal , Konstantinos G. Derpanis

Transformer models have become state-of-the-art in decoding stimuli and behavior from neural activity, significantly advancing neuroscience research. Yet greater transparency in their decision-making processes would substantially enhance…

Quantitative Methods · Quantitative Biology 2025-06-18 Laurence Freeman , Philip Shamash , Vinam Arora , Caswell Barry , Tiago Branco , Eva Dyer

Sparse Autoencoders (SAEs) are powerful tools for interpreting neural representations, yet their use in audio remains underexplored. We train SAEs across all encoder layers of Whisper and HuBERT, provide an extensive evaluation of their…

We present SAE-BrainMap, a novel framework that directly aligns deep learning visual model representations with voxel-level fMRI responses using sparse autoencoders (SAEs). First, we train layer-wise SAEs on model activations and compute…

Neurons and Cognition · Quantitative Biology 2025-06-16 Ziming Mao , Jia Xu , Zeqi Zheng , Haofang Zheng , Dabing Sheng , Yaochu Jin , Guoyuan Yang

One of the roadblocks to a better understanding of neural networks' internals is \textit{polysemanticity}, where neurons appear to activate in multiple, semantically distinct contexts. Polysemanticity prevents us from identifying concise,…

Machine Learning · Computer Science 2023-10-05 Hoagy Cunningham , Aidan Ewart , Logan Riggs , Robert Huben , Lee Sharkey

Unsupervised approaches to large language model (LLM) interpretability, such as sparse autoencoders (SAEs), offer a way to decode LLM activations into interpretable and, ideally, controllable concepts. On the one hand, these approaches…

Machine Learning · Computer Science 2026-03-03 Shruti Joshi , Andrea Dittadi , Sébastien Lachapelle , Dhanya Sridhar

Histopathology images are crucial to the study of complex diseases such as cancer. The histologic characteristics of nuclei play a key role in disease diagnosis, prognosis and analysis. In this work, we propose a sparse Convolutional…

Computer Vision and Pattern Recognition · Computer Science 2017-04-11 Le Hou , Vu Nguyen , Dimitris Samaras , Tahsin M. Kurc , Yi Gao , Tianhao Zhao , Joel H. Saltz

Sparse autoencoders (SAEs) promise a unified approach for mechanistic interpretability, concept discovery, and model steering in LLMs and LVLMs. However, realizing this potential requires learned features to be both interpretable and…

Machine Learning · Computer Science 2026-04-01 Akshay Kulkarni , Tsui-Wei Weng , Vivek Narayanaswamy , Shusen Liu , Wesam A. Sakla , Kowshik Thopalli

Previous studies primarily utilize MLP neurons as units of analysis for understanding the mechanisms of factual knowledge in Language Models (LMs); however, neurons suffer from polysemanticity, leading to limited knowledge expression and…

Computation and Language · Computer Science 2025-02-28 Yuheng Chen , Pengfei Cao , Kang Liu , Jun Zhao

Understanding the multilingual mechanisms of large language models (LLMs) provides insight into how they process different languages, yet this remains challenging. Existing studies often focus on individual neurons, but their polysemantic…

The clinical adoption of artificial intelligence (AI) in medical imaging requires models that are both diagnostically accurate and interpretable to clinicians. While current multimodal biomedical foundation models prioritize performance,…

Large Language Models (LLMs) have transformed natural language processing, yet their internal mechanisms remain largely opaque. Recently, mechanistic interpretability has attracted significant attention from the research community as a…

Machine Learning · Computer Science 2025-09-24 Dong Shu , Xuansheng Wu , Haiyan Zhao , Daking Rai , Ziyu Yao , Ninghao Liu , Mengnan Du

Brain MRI foundation models learn rich representations of anatomy, but interpreting what clinical information they encode remains an open problem. Standard sparse autoencoders (SAEs) suffer from severe feature collapse in deep transformer…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Favour Nerrise , Lucy Yin , Mohammad H. Abbasi , Kilian M. Pohl , Ehsan Adeli

Sparse Autoencoders (SAEs) have proven to be powerful tools for interpreting neural networks by decomposing hidden representations into disentangled, interpretable features via sparsity constraints. However, conventional SAEs are…