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The ion-activated patchy particle model is an important theoretical framework to investigate the phase behaviour of globular proteins in the presence of multivalent ions. In this work, we study and highlight the influence of patch…

Soft Condensed Matter · Physics 2025-11-13 Furio Surfaro , Peixuan Liang , Hadra Banks , Fajun Zhang , Frank Schreiber , Martin Oettel

Phase separation of two phase separating solutes in a common solvent can result in mesoscale (micron-sized) droplets with complex topologies of the domains of each solute within each droplet. Such topologies have been observed in-vitro in…

Soft Condensed Matter · Physics 2025-07-31 Amit Kumar , Gary H. Karpen , Samuel A. Safran

Partial Least Squares (PLS) is a widely used method for data integration, designed to extract latent components shared across paired high-dimensional datasets. Despite decades of practical success, a precise theoretical understanding of its…

Machine Learning · Statistics 2025-12-18 Victor Léger , Florent Chatelain

Liquid-liquid phase separation of liquids exhibiting interconversion between alternative states has been proposed as an underlying mechanism for fluid polyamorphism, and may be of relevance to protein function and intracellular…

Statistical Mechanics · Physics 2021-12-08 Betul Uralcan , Thomas J. Longo , Mikhail A. Anisimov , Frank H. Stillinger , Pablo G. Debenedetti

A lattice model for the study of mixtures of associating liquids is proposed. Solvent and solute are modeled by adapting the associating lattice gas (ALG) model. The nature of interaction solute/solvent is controlled by tuning the energy…

Soft Condensed Matter · Physics 2016-11-03 A. P. Furlan , N. G. Almarza , M. C. Barbosa

Endeavoring toward a transferable, predictive coarse-grained explicit-chain model for biomolecular condensates underlain by liquid-liquid phase separation (LLPS), we conducted multiple-chain simulations of the N-terminal intrinsically…

Biomolecules · Quantitative Biology 2020-12-10 Suman Das , Yi-Hsuan Lin , Robert M. Vernon , Julie D. Forman-Kay , Hue Sun Chan

Semicrystalline polymers (SCP) represent important class of materials used in many applications from packaging to transportation to electronics to pharmaceuticals. Understanding the structure and dynamics of the crystalline and amorphous…

Soft Condensed Matter · Physics 2025-04-28 Valeriy V. Ginzburg

We propose a continuum theory of the liquid-liquid phase separation in an elastic network where phase-separated microscopic droplets rich in one fluid component can form as an interplay of fluids mixing, droplet nucleation, network…

Soft Condensed Matter · Physics 2021-01-04 Xuefeng Wei , Jiajia Zhou , Yanting Wang , Fanlong Meng

Motility-induced phase separation (MIPS) is a nonequilibrium phase separation that has a different origin from equilibrium phase separation induced by attractive interactions. Similarities and differences in collective behaviors between…

Statistical Mechanics · Physics 2024-01-23 Hiroyoshi Nakano , Kyosuke Adachi

In a system of Self-Propelled Particles (SPPs), the combination of self-propulsion and excluded volume effects can result in a phase separation called Motility-Induced Phase Separation (MIPS). Previous studies reported that MIPS is one of…

Soft Condensed Matter · Physics 2025-07-03 Hiroya Yamamoto

We propose that the concept of liquids characterized by a given locally preferred structure (LPS) could help in understanding the observed phenomenon of polyamorphism. ``True polyamorphism'' would involve the competition between two (or…

Statistical Mechanics · Physics 2009-11-07 G. Tarjus , C. Alba-Simionesco , M. Grousson , P. Viot , D. Kivelson

Using Monte Carlo simulations we investigate some new aspects of the phase diagram and the behavior of the diffusion coefficient in an associating lattice gas (ALG) model on different regions of the phase diagram. The ALG model combines a…

Soft Condensed Matter · Physics 2015-05-13 Marcia M. Szortyka , Vera Henriques , Mauricio Girardi , Marcia C. Barbosa

The liquid-liquid phase separation of a binary solvent can be arrested by colloidal particles trapped at the interface [K. Stratford et al., Science 309, 5744 (2005)]. We show experimentally that the colloidal network so formed can remain…

Soft Condensed Matter · Physics 2015-05-14 Eduardo Sanz , Kathryn A. White , Paul S. Clegg , Michael E. Cates

We study the phase behavior and the interfacial tension of the screened Coulomb (Yukawa) restricted primitive model (YRPM) of oppositely charged hard spheres with diameter s using Monte Carlo simulations. We determine the gas-liquid and…

Soft Condensed Matter · Physics 2009-11-11 Andrea Fortini , Antti-Pekka Hynninen , Marjolein Dijkstra

Colloid-polymer mixtures may undergo either fluid-fluid phase separation or gelation. This depends on the depth of the quench (polymer concentration) and polymer-colloid size ratio. We present a real-space study of dynamics in phase…

Soft Condensed Matter · Physics 2012-09-19 Isla Zhang , C. Patrick Royall , Paul Bartlett , Malcolm A. Faers

Liquid-liquid segmented flows in microchannels have been extensively investigated in the context of nanoparticle synthesis. The enhanced mixing in the slugs results in monodispersed particles. Earlier studies have focused on Organic-Aqueous…

Fluid Dynamics · Physics 2023-04-11 Vamsi Vikram Gande , Hima Nandini K , Jagadeesh Korukonda , S Pushpavanam

Liquid-liquid phase separation is ubiquitous in suspensions of nanoparticles, proteins and colloids. With a few notable exceptions, surface-tension-minimizing liquid droplets in bulk suspensions continuously coalesce, increasing in size…

Soft Condensed Matter · Physics 2014-09-10 Prerna Sharma , Andrew Ward , T. Gibaud , Michael F. Hagan , Zvonimir Dogic

Self-consistent field theory (SCFT) is one of the most widely-used framework in studying the equilibrium phase behaviors of inhomogenous polymers. For liquid crystalline polymeric systems, the main numerical challenges of solving SCFT…

Numerical Analysis · Mathematics 2024-09-16 Zhijuan He , Kai Jiang , Liwei Tan , Xin Wang

We study the liquid-vapor phase diagram and the structural properties of discrete potential fluids by means of Gibbs ensemble simulations and integral equations theory. We consider three discrete fluids, namely, the square well (SW), the…

We revisit the associating lattice gas~(ALG) introduced by Henriques \textit{et al.} [PRE 71, 031504 (2005)] in its symmetric version. In this model, defined on the triangular lattice, interaction between molecules occupying…

Statistical Mechanics · Physics 2021-12-16 Ingrid Ibagon , A. P. Furlan , T. J. Oliveira , Ronald Dickman