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During the pretraining phase, large language models (LLMs) acquire vast amounts of knowledge from extensive text corpora. Nevertheless, in later stages such as fine-tuning and inference, the model may encounter knowledge not covered in the…

Computation and Language · Computer Science 2024-10-10 Bozhou Li , Hao Liang , Yang Li , Fangcheng Fu , Hongzhi Yin , Conghui He , Wentao Zhang

Large language models (LLMs) have recently been used as backbones for recommender systems. However, their performance often lags behind conventional methods in standard tasks like retrieval. We attribute this to a mismatch between LLMs'…

Information Retrieval · Computer Science 2024-04-02 Yuwei Cao , Nikhil Mehta , Xinyang Yi , Raghunandan Keshavan , Lukasz Heldt , Lichan Hong , Ed H. Chi , Maheswaran Sathiamoorthy

The training of modern large language models (LLMs) takes place in a regime where most training examples are seen only a few times by the model during the course of training. What does a model remember about such examples seen only a few…

Computation and Language · Computer Science 2023-03-31 A. Emin Orhan

Data science plays a critical role in biomedical research, but it requires professionals with expertise in coding and medical data analysis. Large language models (LLMs) have shown great potential in supporting medical tasks and performing…

Artificial Intelligence · Computer Science 2025-04-10 Zifeng Wang , Benjamin Danek , Ziwei Yang , Zheng Chen , Jimeng Sun

We investigate how well large language models (LLMs) generalize across different task difficulties, a key question for effective data curation and evaluation. Existing research is mixed regarding whether training on easier or harder data…

Computation and Language · Computer Science 2025-11-27 Yeganeh Kordi , Nihal V. Nayak , Max Zuo , Ilana Nguyen , Stephen H. Bach

In the evolving landscape of conversational AI, generating concise, context-aware, and human-like dialogue using small and medium-sized language models (LLMs) remains a complex challenge. This study investigates the influence of LoRA rank,…

Computation and Language · Computer Science 2025-04-15 Chitranshu Harbola , Anupam Purwar

Recent advancements in Large Language Models (LLMs) have showcased their remarkable capabilities in text understanding and generation. However, even stronger LLMs are susceptible to acquiring erroneous or obsolete information from the…

Computation and Language · Computer Science 2024-02-19 Shiwen Ni , Dingwei Chen , Chengming Li , Xiping Hu , Ruifeng Xu , Min Yang

Multimodal large language models (MLLMs) represent an evolutionary expansion in the capabilities of traditional large language models, enabling them to tackle challenges that surpass the scope of purely text-based applications. It leverages…

Computation and Language · Computer Science 2025-01-17 Jinlong He , Pengfei Li , Gang Liu , Genrong He , Zhaolin Chen , Shenjun Zhong

Large language models have demonstrated exceptional performance, yet struggle with complex tasks such as numerical reasoning, plan generation. Integrating external tools, such as calculators and databases, into large language models (LLMs)…

Computation and Language · Computer Science 2025-06-18 Chenghao Li , Liu Liu , Baosheng Yu , Jiayan Qiu , Yibing Zhan

Large pre-trained language models (PLMs) have demonstrated strong performance on natural language understanding (NLU) tasks through fine-tuning. However, fine-tuned models still suffer from overconfident predictions, especially in…

Computation and Language · Computer Science 2023-05-31 Guande He , Jianfei Chen , Jun Zhu

This paper discusses the methods that we used for our submissions to the WMT 2023 Terminology Shared Task for German-to-English (DE-EN), English-to-Czech (EN-CS), and Chinese-to-English (ZH-EN) language pairs. The task aims to advance…

Computation and Language · Computer Science 2025-03-04 Yasmin Moslem , Gianfranco Romani , Mahdi Molaei , Rejwanul Haque , John D. Kelleher , Andy Way

Supervised fine-tuning (SFT) plays a critical role for pretrained large language models (LLMs), notably enhancing their capacity to acquire domain-specific knowledge while preserving or potentially augmenting their general-purpose…

Machine Learning · Computer Science 2026-03-31 Ali Taheri , Alireza Taban , Qizhou Wang , Shanshan Ye , Abdolreza Mirzaei , Tongliang Liu , Bo Han

The parallels between protein sequences and natural language in their sequential structures have inspired the application of large language models (LLMs) to protein understanding. Despite the success of LLMs in NLP, their effectiveness in…

Quantitative Methods · Quantitative Biology 2024-07-09 Yiqing Shen , Zan Chen , Michail Mamalakis , Luhan He , Haiyang Xia , Tianbin Li , Yanzhou Su , Junjun He , Yu Guang Wang

Several recent works seek to develop foundation models specifically for medical applications, adapting general-purpose large language models (LLMs) and vision-language models (VLMs) via continued pretraining on publicly available biomedical…

Computation and Language · Computer Science 2024-11-21 Daniel P. Jeong , Saurabh Garg , Zachary C. Lipton , Michael Oberst

Biomedical literature often uses complex language and inaccessible professional terminologies. That is why simplification plays an important role in improving public health literacy. Applying Natural Language Processing (NLP) models to…

Computation and Language · Computer Science 2024-03-19 Zihao Li , Samuel Belkadi , Nicolo Micheletti , Lifeng Han , Matthew Shardlow , Goran Nenadic

The astonishing success of Large Language Models (LLMs) in Natural Language Processing (NLP) has spurred their use in many application domains beyond text analysis, including wearable sensor-based Human Activity Recognition (HAR). In such…

Machine Learning · Computer Science 2024-06-11 Harish Haresamudram , Hrudhai Rajasekhar , Nikhil Murlidhar Shanbhogue , Thomas Ploetz

This study presents a comprehensive analysis and comparison of two predominant fine-tuning methodologies - full-parameter fine-tuning and parameter-efficient tuning - within the context of medical Large Language Models (LLMs). We developed…

Identification of protein-protein interactions (PPIs) helps derive cellular mechanistic understanding, particularly in the context of complex conditions such as neurodegenerative disorders, metabolic syndromes, and cancer. Large Language…

Machine Learning · Computer Science 2025-08-18 Sanket Jantre , Tianle Wang , Gilchan Park , Kriti Chopra , Nicholas Jeon , Xiaoning Qian , Nathan M. Urban , Byung-Jun Yoon

Having a unified, coherent taxonomy is essential for effective knowledge representation in domain-specific applications as diverse terminologies need to be mapped to underlying concepts. Traditional manual approaches to taxonomy alignment…

Large language models (LLMs) hold great promise in summarizing medical evidence. Most recent studies focus on the application of proprietary LLMs. Using proprietary LLMs introduces multiple risk factors, including a lack of transparency and…