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Fine-tuning LLMs for classification typically maps inputs directly to labels. We ask whether attaching brief explanations to each label during fine-tuning yields better models. We evaluate conversational response quality along three axes:…

Machine Learning · Computer Science 2026-03-03 Vivswan Shah , Randy Cogill , Hanwei Yue , Gopinath Chennupati , Rinat Khaziev

This paper presents the overview of the development and fine-tuning of large language models (LLMs) designed specifically for answering medical questions. We are mainly improving the accuracy and efficiency of providing reliable answers to…

Computation and Language · Computer Science 2025-01-30 Aysegul Ucar , Soumik Nayak , Anunak Roy , Burak Taşcı , Gülay Taşcı

Large Language Model (LLM) fine tuning is underutilized in the field of medicine. Two of the most common methods of fine tuning are Supervised Fine Tuning (SFT) and Direct Preference Optimization (DPO), but there is little guidance…

Computation and Language · Computer Science 2024-12-16 Thomas Savage , Stephen Ma , Abdessalem Boukil , Vishwesh Patel , Ekanath Rangan , Ivan Lopez , Jonathan H Chen

The vocabulary used by language models (LM) - defined by the tokenizer - plays a key role in text generation quality. However, its impact remains under-explored in radiology. In this work, we address this gap by systematically comparing…

Computation and Language · Computer Science 2025-08-14 Hermione Warr , Wentian Xu , Harry Anthony , Yasin Ibrahim , Daniel McGowan , Konstantinos Kamnitsas

Large Language Models (LLMs) exhibit strong general language capabilities. However, fine-tuning these models on domain-specific tasks often leads to catastrophic forgetting, where the model overwrites or loses essential knowledge acquired…

Computation and Language · Computer Science 2025-02-18 Shezheng Song , Hao Xu , Jun Ma , Shasha Li , Long Peng , Qian Wan , Xiaodong Liu , Jie Yu

Metadata play a crucial role in ensuring the findability, accessibility, interoperability, and reusability of datasets. This paper investigates the potential of large language models (LLMs), specifically GPT-4, to improve adherence to…

Artificial Intelligence · Computer Science 2025-02-24 Sowmya S. Sundaram , Benjamin Solomon , Avani Khatri , Anisha Laumas , Purvesh Khatri , Mark A. Musen

Large Language Models (LLMs) have demonstrated excellent performance in general language understanding, generation and other tasks. However, when fine-tuning for specific domain tasks, the general knowledge accumulated in the pre-training…

Computation and Language · Computer Science 2026-04-21 Weijie Wan , Jiangjiang Zhao

The fluency and creativity of large pre-trained language models (LLMs) have led to their widespread use, sometimes even as a replacement for traditional search engines. Yet language models are prone to making convincing but factually…

Computation and Language · Computer Science 2023-11-15 Katherine Tian , Eric Mitchell , Huaxiu Yao , Christopher D. Manning , Chelsea Finn

Aligning terminological resources, including ontologies, controlled vocabularies, taxonomies, and value sets is a critical part of data integration in many domains such as healthcare, chemistry, and biomedical research. Entity mapping is…

Large language models (LLMs) have recently demonstrated exceptional code generation capabilities. However, there is a growing debate whether LLMs are mostly doing memorization (i.e., replicating or reusing large parts of their training…

Artificial Intelligence · Computer Science 2025-10-01 Lizhe Zhang , Wentao Chen , Li Zhong , Letian Peng , Zilong Wang , Jingbo Shang

Purpose: To introduce the concept of using large language models (LLMs) to re-label structure names in accordance with the American Association of Physicists in Medicine (AAPM) Task Group (TG)-263 standard, and to establish a benchmark for…

Biomedical research requires large, diverse samples to produce unbiased results. Automated methods for matching variables across datasets can accelerate this process. Research in this area has been limited, primarily focusing on lexical…

Computation and Language · Computer Science 2024-11-06 Zexu Li , Suraj P. Prabhu , Zachary T. Popp , Shubhi S. Jain , Vijetha Balakundi , Ting Fang Alvin Ang , Rhoda Au , Jinying Chen

Large language models (LLMs) are trained and tested extensively on symbolic representations such as code and graphs, yet real-world user tasks are often specified in natural language. To what extent can LLMs generalize across these…

Computation and Language · Computer Science 2026-02-04 Fangru Lin , Valentin Hofmann , Xingchen Wan , Weixing Wang , Zifeng Ding , Anthony G. Cohn , Janet B. Pierrehumbert

The practice of fine-tuning Large Language Models (LLMs) has achieved state-of-the-art performance on specialized tasks, yet diagnosing why these models become brittle and fail to generalize remains a critical open problem. To address this,…

Artificial Intelligence · Computer Science 2026-01-16 Frank Bobe , Gregory D. Vetaw , Chase Pavlick , Darshan Bryner , Matthew Cook , Jose Salas-Vernis

Large language models (LLMs) with one or more fine-tuning phases have become a necessary step to unlock various capabilities, enabling LLMs to follow natural language instructions or align with human preferences. However, it carries the…

Computation and Language · Computer Science 2024-04-30 Tingfeng Hui , Zhenyu Zhang , Shuohuan Wang , Weiran Xu , Yu Sun , Hua Wu

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

The recent success of large language models (LLMs) has paved the way for their adoption in the high-stakes domain of healthcare. Specifically, the application of LLMs in patient-trial matching, which involves assessing patient eligibility…

Artificial Intelligence · Computer Science 2023-12-18 Mauro Nievas , Aditya Basu , Yanshan Wang , Hrituraj Singh

Despite the remarkable capabilities of modern large language models (LLMs), the mechanisms behind their problem-solving abilities remain elusive. In this work, we aim to better understand how the learning dynamics of LLM finetuning shapes…

Machine Learning · Computer Science 2024-11-19 Katie Kang , Amrith Setlur , Dibya Ghosh , Jacob Steinhardt , Claire Tomlin , Sergey Levine , Aviral Kumar

Machine learning has revolutionized polymer science by enabling rapid property prediction and generative design. Large language models (LLMs) offer further opportunities in polymer informatics by simplifying workflows that traditionally…

Computational Engineering, Finance, and Science · Computer Science 2026-02-20 Sonakshi Gupta , Akhlak Mahmood , Shivank Shukla , Rampi Ramprasad

Specialized clinical AI assistants are rapidly entering medical practice, often framed as safer or more reliable than general-purpose large language models (LLMs). Yet, unlike frontier models, these clinical tools are rarely subjected to…

Computation and Language · Computer Science 2025-12-02 Krithik Vishwanath , Mrigayu Ghosh , Anton Alyakin , Daniel Alexander Alber , Yindalon Aphinyanaphongs , Eric Karl Oermann