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Related papers: BiomedXPro: Prompt Optimization for Explainable Di…

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Effectively adapting powerful pretrained foundation models to diverse tasks remains a key challenge in AI deployment. Current approaches primarily follow two paradigms:discrete optimization of text prompts through prompt engineering, or…

Computation and Language · Computer Science 2025-08-06 Xiaoming Hou , Jiquan Zhang , Zibin Lin , DaCheng Tao , Shengli Zhang

Large Language Models (LLMs) have gained widespread popularity due to their ability to perform ad-hoc Natural Language Processing (NLP) tasks with a simple natural language prompt. Part of the appeal for LLMs is their approachability to the…

Human-Computer Interaction · Computer Science 2025-02-25 Aditi Mishra , Utkarsh Soni , Anjana Arunkumar , Jinbin Huang , Bum Chul Kwon , Chris Bryan

Vision-Language Models (VLMs) have enabled interpretable medical diagnosis by integrating visual perception with linguistic reasoning. Yet, existing medical chain-of-thought (CoT) models lack explicit mechanisms to represent and enforce…

Artificial Intelligence · Computer Science 2026-05-29 Jianxin Lin , Chunzheng Zhu , Peter J. Kneuertz , Yunfei Bai , Yuan Xue

The large-scale pre-trained vision language models (VLM) have shown remarkable domain transfer capability on natural images. However, it remains unknown whether this capability can also apply to the medical image domain. This paper…

Computer Vision and Pattern Recognition · Computer Science 2023-02-08 Ziyuan Qin , Huahui Yi , Qicheng Lao , Kang Li

In the expansion of biomedical dataset, the same category may be labeled with different terms, thus being tedious and onerous to curate these terms. Therefore, automatically mapping synonymous terms onto the ontologies is desirable, which…

Computation and Language · Computer Science 2023-11-29 Hanwen Xu , Jiayou Zhang , Zhirui Wang , Shizhuo Zhang , Megh Manoj Bhalerao , Yucong Liu , Dawei Zhu , Sheng Wang

A major impediment to the transition to context-aware machine translation is the absence of good evaluation metrics and test sets. Sentences that require context to be translated correctly are rare in test sets, reducing the utility of…

Computation and Language · Computer Science 2023-11-07 Rachel Wicks , Matt Post

Prompt engineering has emerged as an indispensable technique for extending the capabilities of large language models (LLMs) and vision-language models (VLMs). This approach leverages task-specific instructions, known as prompts, to enhance…

Artificial Intelligence · Computer Science 2025-03-18 Pranab Sahoo , Ayush Kumar Singh , Sriparna Saha , Vinija Jain , Samrat Mondal , Aman Chadha

To advance biomedical vison-language model capabilities through scaling up, fine-tuning, and instruction tuning, develop vision-language models with improved performance in handling long text, explore strategies to efficiently adopt vision…

Artificial Intelligence · Computer Science 2025-05-26 Cheng Peng , Kai Zhang , Mengxian Lyu , Hongfang Liu , Lichao Sun , Yonghui Wu

Machine learning models that offer excellent predictive performance often lack the interpretability necessary to support integrated human machine decision-making. In clinical medicine and other high-risk settings, domain experts may be…

Machine Learning · Computer Science 2021-04-19 Zach Wood-Doughty , Isabel Cachola , Mark Dredze

Diagnostic prediction and clinical reasoning are critical tasks in healthcare applications. While Large Language Models (LLMs) have shown strong capabilities in commonsense reasoning, they still struggle with diagnostic reasoning due to…

Computation and Language · Computer Science 2026-04-28 Yimin Deng , Zhenxi Lin , Yejing Wang , Guoshuai Zhao , Pengyue Jia , Zichuan Fu , Derong Xu , Yefeng Zheng , Xiangyu Zhao , Li Zhu , Xian Wu , Xueming Qian

System prompts provide a lightweight yet powerful mechanism for conditioning large language models (LLMs) at inference time. While prior work has focused on English-only settings, real-world deployments benefit from having a single prompt…

Computation and Language · Computer Science 2025-12-03 Lechen Zhang , Yusheng Zhou , Tolga Ergen , Lajanugen Logeswaran , Moontae Lee , David Jurgens

Medical question answering requires advanced reasoning that integrates domain knowledge with logical inference. However, existing large language models (LLMs) often generate reasoning chains that lack factual accuracy and clinical…

Computation and Language · Computer Science 2025-12-09 Chia-Hsuan Hsu , Jun-En Ding , Hsin-Ling Hsu , Chih-Ho Hsu , Li-Hung Yao , Chun-Chieh Liao , Feng Liu , Fang-Ming Hung

Deep learning for medical imaging is hampered by task-specific models that lack generalizability and prognostic capabilities, while existing 'universal' approaches suffer from simplistic conditioning and poor medical semantic understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Numan Saeed , Tausifa Jan Saleem , Fadillah Maani , Muhammad Ridzuan , Hu Wang , Mohammad Yaqub

Medical vision-language models (VLMs) show strong performance on radiology tasks but often produce fluent yet weakly grounded conclusions due to over-reliance on a dominant modality. We introduce a context-aligned reasoning framework that…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Sumra Khan , Sagar Chhabriya , Aizan Zafar , Sheeraz Arif , Amgad Muneer , Anas Zafar , Shaina Raza , Rizwan Qureshi

Recent advancements in multimodal foundation models have showcased impressive capabilities in understanding and reasoning with visual and textual information. Adapting these foundation models trained for general usage to specialized domains…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Hejie Cui , Lingjun Mao , Xin Liang , Jieyu Zhang , Hui Ren , Quanzheng Li , Xiang Li , Carl Yang

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Optimization is ubiquitous. While derivative-based algorithms have been powerful tools for various problems, the absence of gradient imposes challenges on many real-world applications. In this work, we propose Optimization by PROmpting…

Machine Learning · Computer Science 2024-04-16 Chengrun Yang , Xuezhi Wang , Yifeng Lu , Hanxiao Liu , Quoc V. Le , Denny Zhou , Xinyun Chen

Data scarcity and privacy concerns limit the availability of high-quality medical images for public use, which can be mitigated through medical image synthesis. However, current medical image synthesis methods often struggle to accurately…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Wenting Chen , Pengyu Wang , Hui Ren , Lichao Sun , Quanzheng Li , Yixuan Yuan , Xiang Li

Although explainability is essential in the clinical diagnosis, most deep learning models still function as black boxes without elucidating their decision-making process. In this study, we investigate the explainable model development that…

Computer Vision and Pattern Recognition · Computer Science 2024-09-20 Yunhe Gao , Difei Gu , Mu Zhou , Dimitris Metaxas

Recent efforts to enable visual navigation using large language models have mainly focused on developing complex prompt systems. These systems incorporate instructions, observations, and history into massive text prompts, which are then…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Yao-Hung Hubert Tsai , Vansh Dhar , Jialu Li , Bowen Zhang , Jian Zhang
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