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In computational pathology, several foundation models have recently emerged and demonstrated enhanced learning capability for analyzing pathology images. However, adapting these models to various downstream tasks remains challenging,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Jeaung Lee , Jeewoo Lim , Keunho Byeon , Jin Tae Kwak

The generation of synthetic clinical trial data offers a promising approach to mitigating privacy concerns and data accessibility limitations in medical research. However, ensuring that synthetic datasets maintain high fidelity, utility,…

Machine Learning · Computer Science 2025-12-16 Waldemar Hahn , Jan-Niklas Eckardt , Christoph Röllig , Martin Sedlmayr , Jan Moritz Middeke , Markus Wolfien

Accurate segmentation of carotid artery structures in histopathological images is vital for cardiovascular disease research. This study systematically evaluates ten deep learning segmentation models including classical architectures, modern…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Phongsakon Mark Konrad , Andrei-Alexandru Popa , Yaser Sabzehmeidani , Liang Zhong , Madhulika Tripathy , Andrei Constantinescu , Elisa A. Liehn , Serkan Ayvaz

Reinforcement learning (RL) applications, where an agent can simply learn optimal behaviors by interacting with the environment, are quickly gaining tremendous success in a wide variety of applications from controlling simple pendulums to…

Machine Learning · Computer Science 2022-01-28 Mariam Kiran , Melis Ozyildirim

Computational pathology foundation models (CPathFMs) have emerged as a powerful approach for analyzing histopathological data, leveraging self-supervised learning to extract robust feature representations from unlabeled whole-slide images.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-27 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Ajit J. Nirmal , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

Continual Learning (CL) is essential for enabling self-evolving large language models (LLMs) to adapt and remain effective amid rapid knowledge growth. Yet, despite its importance, little attention has been given to establishing statistical…

Machine Learning · Computer Science 2025-10-29 Xiaofan Zhou , Lu Cheng

Reinforcement learning is structurally harder than supervised learning because the policy changes the data distribution it learns from. The resulting fragility is especially visible in large-model training, where the training and rollout…

Machine Learning · Computer Science 2026-05-13 Rasool Fakoor , Murdock Aubry , Nicholas Stranges , Alexander J. Smola

Human mesh recovery from single images remains challenging due to inherent depth ambiguity and limited generalization across domains. While recent methods combine regression and optimization approaches, they struggle with poor…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Shaurjya Mandal , Nutan Sharma , John Galeotti

Deep learning for medical imaging suffers from temporal and privacy-related restrictions on data availability. To still obtain viable models, continual learning aims to train in sequential order, as and when data is available. The main…

Image and Video Processing · Electrical Eng. & Systems 2021-07-27 Marius Memmel , Camila Gonzalez , Anirban Mukhopadhyay

Computational reproducibility is a growing problem that has been extensively studied among computational researchers and within the signal processing and machine learning research community. However, with the changing landscape of signal…

Signal Processing · Electrical Eng. & Systems 2022-02-16 Joseph Shenouda , Waheed U. Bajwa

Although binary classification is a well-studied problem, training reliable classifiers under severe class imbalance remains a challenge. Recent techniques mitigate the ill effects of imbalance on training by modifying the loss functions or…

Machine Learning · Computer Science 2024-10-07 Kelsey Lieberman , Swarna Kamlam Ravindran , Shuai Yuan , Carlo Tomasi

Machine learning is facing a 'reproducibility crisis' where a significant number of works report failures when attempting to reproduce previously published results. We evaluate the sources of reproducibility failures using a meta-analysis…

Machine Learning · Computer Science 2023-05-23 Iordanis Fostiropoulos , Bowman Brown , Laurent Itti

Pathology foundation models (PFMs) have advanced rapidly in recent years and support training classifiers for a range of histopathology tasks. However, their robustness across hospitals remains limited: performance often degrades when…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Ben Vardi , Dana Schonberger , Yuval Friedmann , Zohar Yakhini , Iris Barshack , Alexander Loebel , Ariel Shamir

Accurate prediction of biochemical recurrence (BCR) after radical prostatectomy is critical for guiding adjuvant treatment and surveillance decisions in prostate cancer. However, existing clinicopathological risk models reduce complex…

Reproducibility is an important requirement in evolutionary computation, where results largely depend on computational experiments. In practice, reproducibility relies on how algorithms, experimental protocols, and artifacts are documented…

Neural and Evolutionary Computing · Computer Science 2026-02-10 Francesca Da Ros , Tarik Začiragić , Aske Plaat , Thomas Bäck , Niki van Stein

Training massive-scale deep learning models on datasets spanning tens of terabytes presents critical challenges in hardware utilization and training reproducibility. In this paper, we identify and resolve profound data-loading bottlenecks…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-24 Kashish Mittal , Di Yu , Roozbeh Ketabi , Arushi Arora , Brendon Lapp , Peng Zhang

While Deep Reinforcement Learning has been widely researched in medical imaging, the training and deployment of these models usually require powerful GPUs. Since imaging environments evolve rapidly and can be generated by edge devices, the…

Machine Learning · Computer Science 2023-06-09 Guangyao Zheng , Shuhao Lai , Vladimir Braverman , Michael A. Jacobs , Vishwa S. Parekh

Causal representation learning (CRL) models aim to transform high-dimensional data into a latent space, enabling interventions to generate counterfactual samples or modify existing data based on the causal relationships among latent…

Machine Learning · Computer Science 2026-03-19 Alireza Sadeghi , Wael AbdAlmageed

The accelerated adoption of digital pathology and advances in deep learning have enabled the development of powerful models for various pathology tasks across a diverse array of diseases and patient cohorts. However, model training is often…

The development of machine learning models has led to an abundance of datasets containing quantum mechanical (QM) calculations for molecular and material systems. However, traditional training methods for machine learning models are unable…