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The Circle of Willis (CoW) is an important network of arteries connecting major circulations of the brain. Its vascular architecture is believed to affect the risk, severity, and clinical outcome of serious neurovascular diseases. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-09 Kaiyuan Yang , Fabio Musio , Yihui Ma , Norman Juchler , Johannes C. Paetzold , Rami Al-Maskari , Luciano Höher , Hongwei Bran Li , Ibrahim Ethem Hamamci , Anjany Sekuboyina , Suprosanna Shit , Houjing Huang , Chinmay Prabhakar , Ezequiel de la Rosa , Bastian Wittmann , Diana Waldmannstetter , Florian Kofler , Fernando Navarro , Martin Menten , Ivan Ezhov , Daniel Rueckert , Iris N. Vos , Ynte M. Ruigrok , Birgitta K. Velthuis , Hugo J. Kuijf , Pengcheng Shi , Wei Liu , Ting Ma , Maximilian R. Rokuss , Yannick Kirchhoff , Fabian Isensee , Klaus Maier-Hein , Chengcheng Zhu , Huilin Zhao , Philippe Bijlenga , Julien Hämmerli , Catherine Wurster , Laura Westphal , Jeroen Bisschop , Elisa Colombo , Hakim Baazaoui , Hannah-Lea Handelsmann , Andrew Makmur , James Hallinan , Amrish Soundararajan , Bene Wiestler , Jan S. Kirschke , Roland Wiest , Emmanuel Montagnon , Laurent Letourneau-Guillon , Kwanseok Oh , Dahye Lee , Adam Hilbert , Orhun Utku Aydin , Dimitrios Rallios , Jana Rieger , Satoru Tanioka , Alexander Koch , Dietmar Frey , Abdul Qayyum , Moona Mazher , Steven Niederer , Nico Disch , Julius Holzschuh , Dominic LaBella , Francesco Galati , Daniele Falcetta , Maria A. Zuluaga , Chaolong Lin , Haoran Zhao , Zehan Zhang , Minghui Zhang , Xin You , Hanxiao Zhang , Guang-Zhong Yang , Yun Gu , Sinyoung Ra , Jongyun Hwang , Hyunjin Park , Junqiang Chen , Marek Wodzinski , Henning Müller , Nesrin Mansouri , Florent Autrusseau , Cansu Yalçin , Rachika E. Hamadache , Clara Lisazo , Joaquim Salvi , Adrià Casamitjana , Xavier Lladó , Uma Maria Lal-Trehan Estrada , Valeriia Abramova , Luca Giancardo , Arnau Oliver , Paula Casademunt , Adrian Galdran , Matteo Delucchi , Jialu Liu , Haibin Huang , Yue Cui , Zehang Lin , Yusheng Liu , Shunzhi Zhu , Tatsat R. Patel , Adnan H. Siddiqui , Vincent M. Tutino , Maysam Orouskhani , Huayu Wang , Mahmud Mossa-Basha , Yuki Sato , Sven Hirsch , Susanne Wegener , Bjoern Menze

The Circle of Willis (CoW) vessels is critical to connecting major circulations of the brain. The topology of the vascular structure is clinical significance to evaluate the risk, severity of the neuro-vascular diseases. The CoW has two…

Image and Video Processing · Electrical Eng. & Systems 2024-10-22 Minghui Zhang , Xin You , Hanxiao Zhang , Yun Gu

The Circle of Willis (CoW), vital for ensuring consistent blood flow to the brain, is closely linked to ischemic stroke. Accurate assessment of the CoW is important for identifying individuals at risk and guiding appropriate clinical…

Image and Video Processing · Electrical Eng. & Systems 2025-12-04 Wenxuan Zhang , Shuai Li , Xinyi Wang , Yu Sun , Hongyu Kang , Pui Yuk Chryste Wan , Jing Qin , Yuanpeng Zhang , Yong-Ping Zheng , Sai-Kit Lam

Accurate multiclass segmentation of the Circle of Willis (CoW) is essential for neurovascular disease management but remains challenging due to complex vascular topology and variable morphology. Existing deep learning methods often suffer…

Machine Learning · Computer Science 2026-05-01 Jialu Liu , Yue Cui , Shan Yu

Most of the intracranial aneurysms (ICA) occur on a specific portion of the cerebral vascular tree named the Circle of Willis (CoW). More particularly, they mainly arise onto fifteen of the major arterial bifurcations constituting this…

Image and Video Processing · Electrical Eng. & Systems 2023-08-30 Rafic Nader , Romain Bourcier , Florent Autrusseau

Magnetic resonance angiography (MRA) is an imaging modality for visualising blood vessels. It is useful for several diagnostic applications and for assessing the risk of adverse events such as haemorrhagic stroke (resulting from the rupture…

Image and Video Processing · Electrical Eng. & Systems 2023-08-25 Yash Deo , Rodrigo Bonazzola , Haoran Dou , Yan Xia , Tianyou Wei , Nishant Ravikumar , Alejandro F. Frangi , Toni Lassila

Cerebral hemodynamics is fundamentally regulated by the Circle of Willis (CoW), which redistributes flow through communicating arteries to stabilize perfusion under anatomical variations and vascular stenosis. In this study, we develop a…

Medical Physics · Physics 2025-12-22 Jiawei Liu , Atsushi Kanoke , Hidenori Endo , Kuniyasu Niizuma , Hiroshi Suito

Intracranial aneurysms (ICA) commonly occur in specific segments of the Circle of Willis (CoW), primarily, onto thirteen major arterial bifurcations. An accurate detection of these critical landmarks is necessary for a prompt and efficient…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Rafic Nader , Vincent L'Allinec , Romain Bourcier , Florent Autrusseau

Blood vessel networks in the brain play a crucial role in stroke research, where understanding their topology is essential for analyzing blood flow dynamics. However, extracting detailed topological vessel network information from…

Computer Vision and Pattern Recognition · Computer Science 2025-04-17 Joël Mathys , Andreas Plesner , Jorel Elmiger , Roger Wattenhofer

Accurate segmentation of cerebral vasculature and a quantitative assessment of cerebrovascular morphology is critical to various diagnostic and therapeutic purposes and is pertinent to studying brain health and disease. However, this is…

Quantitative Methods · Quantitative Biology 2020-02-27 Aditi Deshpande , Nima Jamilpour , Bin Jiang , Chelsea Kidwell , Max Wintermark , Kaveh Laksari

We present CaravelMetrics, a computational framework for automated cerebrovascular analysis that models vessel morphology through skeletonization-derived graph representations. The framework integrates atlas-based regional parcellation,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Daniele Falcetta , Liane S. Canas , Lorenzo Suppa , Matteo Pentassuglia , Jon Cleary , Marc Modat , Sébastien Ourselin , Maria A. Zuluaga

During the diagnosis of ischemic strokes, the Circle of Willis and its surrounding vessels are the arteries of interest. Their visualization in case of an acute stroke is often enabled by Computed Tomography Angiography (CTA). Still, the…

Image and Video Processing · Electrical Eng. & Systems 2022-04-27 Florian Thamm , Markus Jürgens , Oliver Taubmann , Aleksandra Thamm , Leonhard Rist , Hendrik Ditt , Andreas Maier

Developing automated and semi-automated solutions for reconstructing wiring diagrams of the brain from electron micrographs is important for advancing the field of connectomics. While the ultimate goal is to generate a graph of neuron…

Computer Vision and Pattern Recognition · Computer Science 2016-08-09 William Gray Roncal , Colin Lea , Akira Baruah , Gregory D. Hager

A novel centerline extraction framework is reported which combines an end-to-end trainable multi-task fully convolutional network (FCN) with a minimal path extractor. The FCN simultaneously computes centerline distance maps and detects…

Computer Vision and Pattern Recognition · Computer Science 2019-03-26 Zhihui Guo , Junjie Bai , Yi Lu , Xin Wang , Kunlin Cao , Qi Song , Milan Sonka , Youbing Yin

Over the past decades, various metrics have emerged in graph theory to grasp the complex nature of network vulnerability. In this paper, we study two specific measures: (weighted) vertex integrity (wVI) and (weighted) component order…

Data Structures and Algorithms · Computer Science 2024-12-02 Katrin Casel , Tobias Friedrich , Aikaterini Niklanovits , Kirill Simonov , Ziena Zeif

Vessel segmentation and centerline extraction are two crucial preliminary tasks for many computer-aided diagnosis tools dealing with vascular diseases. Recently, deep-learning based methods have been widely applied to these tasks. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-02-23 Pierre Rougé , Nicolas Passat , Odyssée Merveille

Convolutional neural network (CNN) based segmentation methods provide an efficient and automated way for clinicians to assess the structure and function of the heart in cardiac MR images. While CNNs can generally perform the segmentation…

The midline related pathological image features are crucial for evaluating the severity of brain compression caused by stroke or traumatic brain injury (TBI). The automated midline delineation not only improves the assessment and clinical…

Image and Video Processing · Electrical Eng. & Systems 2020-02-28 Shen Wang , Kongming Liang , Chengwei Pan , Chuyang Ye , Xiuli Li , Feng Liu , Yizhou Yu , Yizhou Wang

Random walk centrality is a fundamental metric in graph mining for quantifying node importance and influence, defined as the weighted average of hitting times to a node from all other nodes. Despite its ability to capture rich graph…

Artificial Intelligence · Computer Science 2025-10-24 Changan Liu , Zixuan Xie , Ahad N. Zehmakan , Zhongzhi Zhang

Scoliosis is a condition defined by an abnormal spinal curvature. For diagnosis and treatment planning of scoliosis, spinal curvature can be estimated using Cobb angles. We propose an automated method for the estimation of Cobb angles from…

Image and Video Processing · Electrical Eng. & Systems 2019-12-12 Florian Dubost , Benjamin Collery , Antonin Renaudier , Axel Roc , Nicolas Posocco , Gerda Bortsova , Wiro Niessen , Marleen de Bruijne
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