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The resilience of cyberphysical systems to denial-of-service (DoS) and integrity attacks is studied in this paper. The cyberphysical system is modeled as a linear structured system, and its resilience to an attack is interpreted in a graph…

Systems and Control · Electrical Eng. & Systems 2021-09-06 Bhaskar Ramasubramanian , M. A. Rajan , M. Girish Chandra , Rance Cleaveland , Steven I. Marcus

The ability to continually learn, retain and deploy skills to accomplish goals is a key feature of intelligent and efficient behavior. However, the neural mechanisms facilitating the continual learning and flexible (re-)composition of…

Machine Learning · Computer Science 2025-10-24 Haozhe Shan , Sun Minni , Lea Duncker

Input-to-state stability (ISS) allows estimating the impact of inputs and initial conditions on both the intermediate values and the asymptotic bound on the solutions. ISS has unified the input-output and Lyapunov stability theories and is…

Optimization and Control · Mathematics 2023-02-02 Andrii Mironchenko

We show that if a chemical reaction network (CRN) admits nondegenerate (resp., linearly stable) oscillation, and we add new reversible reactions involving new species to this CRN, then the new CRN so created also admits nondegenerate…

Dynamical Systems · Mathematics 2021-06-14 Murad Banaji

Robustness of biochemical systems has become one of the central questions in systems biology although it is notoriously difficult to formally capture its multifaceted nature. Maintenance of normal system function depends not only on the…

Molecular Networks · Quantitative Biology 2012-03-28 Jost Neigenfind , Sergio Grimbs , Zoran Nikoloski

In a pedagogical but exhaustive manner, this survey reviews the main results on input-to-state stability (ISS) for infinite-dimensional systems. This property allows estimating the impact of inputs and initial conditions on both the…

Optimization and Control · Mathematics 2020-03-09 Andrii Mironchenko , Christophe Prieur

Many biochemical and industrial applications involve complicated networks of simultaneously occurring chemical reactions. Under the assumption of mass action kinetics, the dynamics of these chemical reaction networks are governed by systems…

Dynamical Systems · Mathematics 2014-07-15 Matthew D. Johnston

Understanding the insulin signaling cascade provides insights on the underlying mechanisms of biological phenomena such as insulin resistance, diabetes, Alzheimer's disease, and cancer. For this reason, previous studies utilized chemical…

Molecular Networks · Quantitative Biology 2024-05-20 Patrick Vincent N. Lubenia , Eduardo R. Mendoza , Angelyn R. Lao

Cluster states are versatile quantum resources and an essential building block for measurement-based quantum computing. The possibility to generate cluster states in specific systems may thus serve as an indicator regarding if and to what…

Quantum Physics · Physics 2024-01-19 Zheng-Yang Zhou , Clemens Gneiting , J. Q. You , Franco Nori

Stochastic chemical processes are described by the chemical master equation satisfying the law of mass-action. We first ask whether the dual master equation, which has the same steady state as the chemical master equation, but with inverted…

We consider the interconnections of arbitrary topology of a finite number of ISS hybrid systems and study whether the ISS property is maintained for the overall system. We show that if the small gain condition is satisfied, then the whole…

Dynamical Systems · Mathematics 2012-02-28 Sergey Dashkovskiy , Michael Kosmykov

The promise of chemical computation lies in controlling systems incompatible with traditional electronic micro-controllers, with applications in synthetic biology and nano-scale manufacturing. Computation is typically embedded in…

Emerging Technologies · Computer Science 2019-02-11 Keenan Breik , Chris Thachuk , Marijn Heule , David Soloveichik

The popularity of molecular computation has given rise to several models of abstraction, one of the more recent ones being Chemical Reaction Networks (CRNs). These are equivalent to other popular computational models, such as Vector…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-02-28 Robert M. Alaniz , Bin Fu , Timothy Gomez , Elise Grizzell , Andrew Rodriguez , Marco Rodriguez , Robert Schweller , Tim Wylie

Complex, interconnected Cyber-physical Systems (CPS) are increasingly common in applications including smart grids and transportation. Ensuring safety of interconnected systems whose dynamics are coupled is challenging because the effects…

Systems and Control · Electrical Eng. & Systems 2023-01-02 Abdullah Al Maruf , Luyao Niu , Andrew Clark , J. Sukarno Mertoguno , Radha Poovendran

A family of results, referred to as inheritance results, tell us which enlargements of a chemical reaction network (CRN) preserve its capacity for nontrivial behaviours such as multistationarity and oscillation. In this paper, the following…

Dynamical Systems · Mathematics 2023-02-23 Murad Banaji

Reversibility, weak reversibility and deficiency, detailed and complex balancing are generally not "encoded" in the kinetic differential equations but they are realization properties that may imply local or even global asymptotic stability…

Molecular Networks · Quantitative Biology 2011-05-11 Gabor Szederkenyi , Katalin M. Hangos

We consider how to generate chemical reaction networks (CRNs) from functional specifications. We propose a two-stage approach that combines synthesis by satisfiability modulo theories and Markov chain Monte Carlo based optimisation. First,…

Emerging Technologies · Computer Science 2015-08-19 Neil Dalchau , Niall Murphy , Rasmus Petersen , Boyan Yordanov

Reservoir computing is a popular approach to design recurrent neural networks, due to its training simplicity and approximation performance. The recurrent part of these networks is not trained (e.g., via gradient descent), making them…

Neural and Evolutionary Computing · Computer Science 2021-02-15 Pietro Verzelli , Cesare Alippi , Lorenzo Livi , Peter Tino

Convolutional neural networks (CNNs) play a key role in deep learning applications. However, the large storage overheads and the substantial computation cost of CNNs are problematic in hardware accelerators. Computing-in-memory (CIM)…

Hardware Architecture · Computer Science 2021-05-26 Syuan-Hao Sie , Jye-Luen Lee , Yi-Ren Chen , Chih-Cheng Lu , Chih-Cheng Hsieh , Meng-Fan Chang , Kea-Tiong Tang

Chemical systems are interpreted through the species they contain and the reactions they may undergo, i.e., their chemical reaction network (CRN). In spite of their central importance to chemistry, the structure of CRNs continues to be…

Statistical Mechanics · Physics 2025-06-17 Alex Blokhuis , Martijn van Kuppeveld , Daan van de Weem , Robert Pollice