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Large language models (LLMs) show significant potential in healthcare, prompting numerous benchmarks to evaluate their capabilities. However, concerns persist regarding the reliability of these benchmarks, which often lack clinical…

Computation and Language · Computer Science 2026-04-30 Wenting Chen , Guo Yu , Yiu-Fai Cheung , Meidan Ding , Jie Liu , Zizhan Ma , Wenxuan Wang , Linlin Shen

With the increasing use of large language models (LLMs) in medical decision-support, it is essential to evaluate not only their final answers but also the reliability of their reasoning. Two key risks are Chain-of-Thought (CoT) faithfulness…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Kaiyuan Ji , Yijin Guo , Zicheng Zhang , Xiangyang Zhu , Yuan Tian , Ning Liu , Guangtao Zhai

Large Language Models (LLMs) in mental healthcare risk propagating biases that reinforce stigma and harm marginalized groups. While previous research identified concerning trends, systematic methods for detecting intersectional biases…

Computation and Language · Computer Science 2025-06-24 Batool Haider , Atmika Gorti , Aman Chadha , Manas Gaur

Patient-clinician communication is an asymmetric-information problem: patients often do not disclose fears, misconceptions, or practical barriers unless clinicians elicit them skillfully. Effective medical dialogue therefore requires…

Computation and Language · Computer Science 2026-04-13 Yikun Han , Joey Chan , Jingyuan Chen , Mengting Ai , Simo Du , Yue Guo

Multimodal large language models (MLLMs) achieve strong performance on single-view spatial reasoning tasks, yet it remains unclear whether they maintain stable spatial state representations under counterfactual viewpoint changes. We…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Shanmukha Vellamcheti , Uday Kiran Kothapalli , Disharee Bhowmick , Sathyanarayanan N. Aakur

Large language models (LLMs) are increasingly envisioned as decision-support tools in clinical practice, yet safe clinical reasoning demands integrating heterogeneous knowledge bases -- trials, primary studies, regulatory documents, and…

Computation and Language · Computer Science 2025-05-22 Shan Chen , Pedro Moreira , Yuxin Xiao , Sam Schmidgall , Jeremy Warner , Hugo Aerts , Thomas Hartvigsen , Jack Gallifant , Danielle S. Bitterman

Current medical AI systems often fail to replicate real-world clinical reasoning, as they are predominantly trained and evaluated on static text and question-answer tasks. These tuning methods and benchmarks overlook critical aspects like…

Computation and Language · Computer Science 2026-02-24 Zijie Liu , Xinyu Zhao , Jie Peng , Zhuangdi Zhu , Qingyu Chen , Kaidi Xu , Xia Hu , Tianlong Chen

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

Intensive care units (ICU) generate long, dense and evolving streams of clinical information, where physicians must repeatedly reassess patient states under time pressure, underscoring a clear need for reliable AI decision support. Existing…

Artificial Intelligence · Computer Science 2026-05-14 Chengzhi Shen , Weixiang Shen , Tobias Susetzky , Chen , Chen , Jun Li , Yuyuan Liu , Xuepeng Zhang , Zhenyu Gong , Daniel Rueckert , Jiazhen Pan

Multimodal Large Language Models (MLLMs) have tremendous potential to improve the accuracy, availability, and cost-effectiveness of healthcare by providing automated solutions or serving as aids to medical professionals. Despite promising…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Mohammad Shahab Sepehri , Zalan Fabian , Maryam Soltanolkotabi , Mahdi Soltanolkotabi

We introduce MedXpertQA, a highly challenging and comprehensive benchmark to evaluate expert-level medical knowledge and advanced reasoning. MedXpertQA includes 4,460 questions spanning 17 specialties and 11 body systems. It includes two…

Artificial Intelligence · Computer Science 2025-06-09 Yuxin Zuo , Shang Qu , Yifei Li , Zhangren Chen , Xuekai Zhu , Ermo Hua , Kaiyan Zhang , Ning Ding , Bowen Zhou

Large language models (LLMs) are increasingly used for diagnostic tasks in medicine. In clinical practice, the correct diagnosis can rarely be immediately inferred from the initial patient presentation alone. Rather, reaching a diagnosis…

Artificial Intelligence · Computer Science 2026-02-20 Hui Min Wong , Philip Heesen , Pascal Janetzky , Martin Bendszus , Stefan Feuerriegel

Large language models (LLMs) hold promise to serve complex health information needs but also have the potential to introduce harm and exacerbate health disparities. Reliably evaluating equity-related model failures is a critical step toward…

Large Language Models (LLMs) can produce verbalized self-explanations, yet prior studies suggest that such rationales may not reliably reflect the model's true decision process. We ask whether these explanations nevertheless help users…

Computation and Language · Computer Science 2026-01-08 Pingjun Hong , Benjamin Roth

Medical consumer question answering (CQA) is crucial for empowering patients by providing personalized and reliable health information. Despite recent advances in large language models (LLMs) for medical QA, consumer-oriented and…

Computation and Language · Computer Science 2025-05-27 Naghmeh Jamali , Milad Mohammadi , Danial Baledi , Zahra Rezvani , Hesham Faili

Large Language Models (LLMs) have demonstrated remarkable performance on various medical question-answering (QA) benchmarks, including standardized medical exams. However, correct answers alone do not ensure correct logic, and models may…

Computation and Language · Computer Science 2025-06-02 Yuexing Hao , Kumail Alhamoud , Hyewon Jeong , Haoran Zhang , Isha Puri , Philip Torr , Mike Schaekermann , Ariel D. Stern , Marzyeh Ghassemi

Large Language Models (LLMs) have demonstrated strong performance in question answering (QA) tasks. However, Multi-Answer Question Answering (MAQA), where a question may have several valid answers, remains challenging. Traditional QA…

Computation and Language · Computer Science 2025-08-19 Eviatar Nachshoni , Arie Cattan , Shmuel Amar , Ori Shapira , Ido Dagan

Large language models (LLMs) are capable of many natural language tasks, yet they are far from perfect. In health applications, grounding and interpreting domain-specific and non-linguistic data is crucial. This paper investigates the…

Computation and Language · Computer Science 2024-04-30 Yubin Kim , Xuhai Xu , Daniel McDuff , Cynthia Breazeal , Hae Won Park

Advancements in Large Language Models (LLMs) and their increasing use in medical question-answering necessitate rigorous evaluation of their reliability. A critical challenge lies in hallucination, where models generate plausible yet…

Computation and Language · Computer Science 2025-02-21 Shrey Pandit , Jiawei Xu , Junyuan Hong , Zhangyang Wang , Tianlong Chen , Kaidi Xu , Ying Ding