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Medical question-answering (QA) is a critical task for evaluating how effectively large language models (LLMs) encode clinical knowledge and assessing their potential applications in medicine. Despite showing promise on multiple-choice…

Computation and Language · Computer Science 2025-03-06 Guangfu Guo , Kai Zhang , Bryan Hoo , Yujun Cai , Xiaoqian Lu , Nanyun Peng , Yiwei Wang

Counterfactuals refer to minimally edited inputs that cause a model's prediction to change, serving as a promising approach to explaining the model's behavior. Large language models (LLMs) excel at generating English counterfactuals and…

Computation and Language · Computer Science 2026-04-07 Qianli Wang , Van Bach Nguyen , Yihong Liu , Fedor Splitt , Nils Feldhus , Christin Seifert , Hinrich Schütze , Sebastian Möller , Vera Schmitt

Clinical problem-solving requires processing of semantic medical knowledge such as illness scripts and numerical medical knowledge of diagnostic tests for evidence-based decision-making. As large language models (LLMs) show promising…

Despite achieving high accuracy on medical benchmarks, LLMs exhibit the Einstellung Effect in clinical diagnosis--relying on statistical shortcuts rather than patient-specific evidence, causing misdiagnosis in atypical cases. Existing…

Computation and Language · Computer Science 2026-01-13 Wenting Chen , Zhongrui Zhu , Guolin Huang , Wenxuan Wang

Large language models (LLMs) have shown considerable potential in supporting medical diagnosis. However, their effective integration into clinical workflows is hindered by physicians' difficulties in perceiving and trusting LLM…

Human-Computer Interaction · Computer Science 2026-01-28 Yuansong Xu , Yichao Zhu , Haokai Wang , Yuchen Wu , Yang Ouyang , Hanlu Li , Wenzhe Zhou , Xinyu Liu , Chang Jiang , Quan Li

Current evaluation of large language models (LLMs) overwhelmingly prioritizes accuracy; however, in real-world and safety-critical applications, the ability to abstain when uncertain is equally vital for trustworthy deployment. We introduce…

Computation and Language · Computer Science 2026-01-23 Sravanthi Machcha , Sushrita Yerra , Sahil Gupta , Aishwarya Sahoo , Sharmin Sultana , Hong Yu , Zonghai Yao

In high-stakes domains like medicine, it may be generally desirable for models to faithfully adhere to the context provided. But what happens if the context does not align with model priors or safety protocols? In this paper, we investigate…

Computation and Language · Computer Science 2026-04-21 Kaijie Mo , Siddhartha Venkatayogi , Chantal Shaib , Ramez Kouzy , Wei Xu , Byron C. Wallace , Junyi Jessy Li

Recent advancements in Large Language Models (LLMs) have positioned them as powerful tools for clinical decision-making, with rapidly expanding applications in healthcare. However, concerns about bias remain a significant challenge in the…

Artificial Intelligence · Computer Science 2024-10-23 Kenza Benkirane , Jackie Kay , Maria Perez-Ortiz

Patients are increasingly turning to large language models (LLMs) with medical questions that are complex and difficult to articulate clearly. However, LLMs are sensitive to prompt phrasings and can be influenced by the way questions are…

Computation and Language · Computer Science 2026-04-08 Hye Sun Yun , Geetika Kapoor , Michael Mackert , Ramez Kouzy , Wei Xu , Junyi Jessy Li , Byron C. Wallace

Large Language Models (LLMs) have demonstrated impressive capabilities across a range of scientific tasks including mathematics, physics, and chemistry. Despite their successes, the effectiveness of LLMs in handling complex statistical…

Computation and Language · Computer Science 2024-10-11 Yizhang Zhu , Shiyin Du , Boyan Li , Yuyu Luo , Nan Tang

Integrating large language models (LLMs) like DeepSeek R1 into healthcare requires rigorous evaluation of their reasoning alignment with clinical expertise. This study assesses DeepSeek R1's medical reasoning against expert patterns using…

Computation and Language · Computer Science 2025-04-02 Birger Moell , Fredrik Sand Aronsson , Sanian Akbar

Demand for mental health support through AI chatbots is surging, though current systems present several limitations, like sycophancy or overvalidation, and reinforcement of maladaptive beliefs. A core obstacle to the creation of better…

Computation and Language · Computer Science 2025-12-08 José Pombal , Maya D'Eon , Nuno M. Guerreiro , Pedro Henrique Martins , António Farinhas , Ricardo Rei

Artificial intelligence (AI) and large language models (LLMs) in healthcare require advanced clinical skills (CS), yet current benchmarks fail to evaluate these comprehensively. We introduce MedQA-CS, an AI-SCE framework inspired by medical…

Artificial Intelligence · Computer Science 2026-01-21 Zonghai Yao , Zihao Zhang , Chaolong Tang , Xingyu Bian , Youxia Zhao , Zhichao Yang , Junda Wang , Huixue Zhou , Won Seok Jang , Feiyun Ouyang , Hong Yu

Large Language Models (LLMs) have been shown to encode clinical knowledge. Many evaluations, however, rely on structured question-answer benchmarks, overlooking critical challenges of interpreting and reasoning about unstructured clinical…

Computation and Language · Computer Science 2026-04-01 Meghal Dani , Muthu Jeyanthi Prakash , Filip Rosa , Zeynep Akata , Stefanie Liebe

While large language models now handle million-token contexts, their capacity for reasoning across entire document repositories remains largely untested. Existing benchmarks are inadequate, as they are mostly limited to single long texts or…

Computation and Language · Computer Science 2026-04-28 Zhiyuan Lu , Chenliang Li , Yingcheng Shi , Weizhou Shen , Ming Yan , Fei Huang

Temporal reasoning is fundamental for large language models (LLMs) to comprehend the world. Current temporal reasoning datasets are limited to questions about single or isolated events, falling short in mirroring the realistic temporal…

Computation and Language · Computer Science 2024-06-14 Zhaochen Su , Juntao Li , Jun Zhang , Tong Zhu , Xiaoye Qu , Pan Zhou , Yan Bowen , Yu Cheng , Min zhang

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Can AI be cognitively biased in automated information judgment tasks? Despite recent progresses in measuring and mitigating social and algorithmic biases in AI and large language models (LLMs), it is not clear to what extent LLMs behave…

Information Retrieval · Computer Science 2024-11-26 Jiqun Liu , Jiangen He

Large language models (LLMs) are rapidly transitioning into medical clinical use, yet their reliability under realistic, multi-turn interactions remains poorly understood. Existing evaluation frameworks typically assess single-turn question…

Computation and Language · Computer Science 2025-10-15 Blazej Manczak , Eric Lin , Francisco Eiras , James O' Neill , Vaikkunth Mugunthan

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng