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Machine learning potentials (MLPs) trained on accurate quantum chemical data can retain the high accuracy, while inflicting little computational demands. On the downside, they need to be trained for each individual system. In recent years,…

Machine Learning · Computer Science 2023-09-13 Marco Eckhoff , Markus Reiher

Learning from data has led to paradigm shifts in a multitude of disciplines, including web, text, and image search, speech recognition, as well as bioinformatics. Can machine learning enable similar breakthroughs in understanding quantum…

Due to rapid advancements in deep learning techniques, the demand for large-volume high-quality databases grows significantly in chemical research. We developed a quantum-chemistry database that includes 443,106 small organic molecules with…

Chemical Physics · Physics 2024-06-05 Yifei Zhu , Mengge Li , Chao Xu , Zhenggang Lan

Quantum kernel methods offer significant theoretical benefits by rendering classically inseparable features separable in quantum space. Yet, the practical application of Quantum Machine Learning (QML), currently constrained by the…

Machine Learning · Computer Science 2026-02-03 Philipp Altmann , Maximilian Mansky , Maximilian Zorn , Jonas Stein , Claudia Linnhoff-Popien

Quantum Machine Learning (QML) models of molecular HOMO-LUMO-gaps often struggle to achieve satisfying data-efficiency as measured by decreasing prediction errors for increasing training set sizes. Partitioning training sets of organic…

Chemical Physics · Physics 2021-10-07 Bernard Mazouin , Alexandre Alain Schöpfer , O. Anatole von Lilienfeld

Machine learning (ML) has emerged into formidable force for identifying hidden but pertinent patterns within a given data set with the objective of subsequent generation of automated predictive behavior. In the recent years, it is safe to…

Quantum computers hold promise to circumvent the limitations of conventional computing for difficult molecular problems. However, the accumulation of quantum logic errors on real devices represents a major challenge, particularly in the…

Chemical Physics · Physics 2021-11-17 Michael A. Jones , Harish J. Vallury , Charles D. Hill , Lloyd C. L. Hollenberg

Large language models (LLMs) have gained significant attention in chemistry. However, most existing datasets center on molecular-level property prediction and overlook the role of fine-grained functional group (FG) information.…

Machine Learning · Computer Science 2026-02-17 Xuan Liu , Siru Ouyang , Xianrui Zhong , Jiawei Han , Huimin Zhao

Quantum machine learning (QML) leverages the potential from machine learning to explore the subtle patterns in huge datasets of complex nature with quantum advantages. This exponentially reduces the time and resources necessary for…

Materials Science · Physics 2024-05-30 Kurudi V Vedavyasa , Ashok Kumar

A long-standing goal of science is to accurately solve the Schr\"odinger equation for large molecular systems. The poor scaling of current quantum chemistry algorithms on classical computers imposes an effective limit of about a few dozen…

Chemical Physics · Physics 2022-02-11 Joshua A. Rackers , Lucas Tecot , Mario Geiger , Tess E. Smidt

Machine learning potentials (MLP) have revolutionized the field of atomistic simulations by describing the atomic interactions with the accuracy of electronic structure methods at a small fraction of the costs. Most current MLPs construct…

Computational Physics · Physics 2024-12-09 Moritz Gubler , Jonas A. Finkler , Moritz R. Schäfer , Jörg Behler , Stefan Goedecker

Advancements in the implementation of quantum hardware have enabled the acquisition of data that are intractable for emulation with classical computers. The integration of classical machine learning (ML) algorithms with these data holds…

Quantum Physics · Physics 2025-01-22 Gyungmin Cho , Dohun Kim

Quantum machine learning (QML) promises significant speedups, particularly when operating on quantum datasets. However, its progress is hindered by the scarcity of suitable training data. Existing synthetic data generation methods fall…

Emerging Technologies · Computer Science 2026-03-24 Jason Ludmir , Ian Martin , Nicholas S. DiBrita , Tirthak Patel

Quantum Monte Carlo (QMC) is a powerful method to calculate accurate energies and forces for molecular systems. In this work, we demonstrate how we can obtain accurate QMC forces for the fluxional ethanol molecule at room temperature by…

The complexity of biological systems and processes, spanning molecular to macroscopic scales, necessitates the use of multiscale simulations to get a comprehensive understanding. Quantum mechanics/molecular mechanics (QM/MM) molecular…

The aim of this paper is to introduce a quantum fusion mechanism for multimodal learning and to establish its theoretical and empirical potential. The proposed method, called the Quantum Fusion Layer (QFL), replaces classical fusion schemes…

Quantum Physics · Physics 2025-10-09 Tuyen Nguyen , Trong Nghia Hoang , Phi Le Nguyen , Hai L. Vu , Truong Cong Thang

We introduce machine learning models of quantum mechanical observables of atoms in molecules. Instant out-of-sample predictions for proton and carbon nuclear chemical shifts, atomic core level excitations, and forces on atoms reach…

Chemical Physics · Physics 2015-08-26 Matthias Rupp , Raghunathan Ramakrishnan , O. Anatole von Lilienfeld

Machine learning force fields (MLFFs) are an increasingly popular choice for atomistic simulations due to their high fidelity and improvable nature. Here, we propose a hybrid small-cell approach that combines attributes of both offline and…

Computational Physics · Physics 2023-06-02 Yu Luo , Jason A. Meziere , German D. Samolyuk , Gus L. W. Hart , Mark R Daymond , Laurent Karim Béland

In the field of quantum machine learning (QML), parametrized quantum circuits (PQCs) -- constructed using a combination of fixed and tunable quantum gates -- provide a promising hybrid framework for tackling complex machine learning…

Quantum Physics · Physics 2025-09-19 Grier M. Jones , Viki Kumar Prasad , Ulrich Fekl , Hans-Arno Jacobsen

Quantum machine learning (QML) seeks to exploit the intrinsic properties of quantum mechanical systems, including superposition, coherence, and quantum entanglement for classical data processing. However, due to the exponential growth of…

Quantum Physics · Physics 2025-10-09 Timothy Heightman , Edward Jiang , Ruth Mora-Soto , Maciej Lewenstein , Marcin Płodzień