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We use Physics-Informed Neural Networks (PINNs) to solve the discrete-time nonlinear observer state estimation problem. Integrated within a single-step exact observer linearization framework, the proposed PINN approach aims at learning a…

The coronavirus disease 2019 (COVID-19) pandemic radically impacts our lives, while the transmission/infection and recovery dynamics of COVID-19 remain obscure. A time-dependent Susceptible, Exposed, Infectious, and Recovered (SEIR) model…

Populations and Evolution · Quantitative Biology 2020-04-01 Yong Zhang , Xiangnan Yu , HongGuang Sun , Geoffrey R. Tick , Wei Wei , Bin Jin

We present three data driven model-types for COVID-19 with a minimal number of parameters to provide insights into the spread of the disease that may be used for developing policy responses. The first is exponential growth, widely studied…

Populations and Evolution · Quantitative Biology 2022-05-25 Andrea L. Bertozzi , Elisa Franco , George Mohler , Martin B. Short , Daniel Sledge

The worldwide spread of COVID-19 has called for fast advancement of new modelling strategies to estimate its unprecedented spread. Here, we introduce a model based on the fundamental SIR equations with a stochastic disorder by a random…

Physics and Society · Physics 2020-04-28 Suman Dutta

Vector-borne diseases continue to pose a significant health threat globally with more than 3 billion people at risk each year. Despite some limitations, mechanistic dynamic models are a popular approach to representing biological processes…

In this work, we propose a deep learning approach to forecasting state-level COVID-19 trends of weekly cumulative death in the United States (US) and incident cases in Germany. This approach includes a transformer model, an ensemble method,…

Machine Learning · Computer Science 2023-02-03 Chung Yan Fong , Dit-Yan Yeung

Physics-informed neural networks (PINNs) are neural networks that embed the laws of dynamical systems modeled by differential equations into their loss function as constraints. In this work, we present a PINN framework applied to oncology.…

Machine Learning · Computer Science 2025-10-16 Kayode Olumoyin , Katarzyna Rejniak

Physics-Informed Neural Networks (PINNs) have emerged as an influential technology, merging the swift and automated capabilities of machine learning with the precision and dependability of simulations grounded in theoretical physics. PINNs…

This is work in progress. We make it accessible hoping that people might find the idea useful. We propose a discrete, recursive 5-compartment model for the spread of epidemics, which we call {\em SEPIR-model}. Under mild assumptions which…

Populations and Evolution · Quantitative Biology 2020-09-02 Matthias Kreck , Erhard Scholz

The outbreak of COVID-19 in 2020 has led to a surge in interest in the mathematical modeling of infectious diseases. Such models are usually defined as compartmental models, in which the population under study is divided into compartments…

Populations and Evolution · Quantitative Biology 2021-02-16 Malú Grave , Alex Viguerie , Gabriel F. Barros , Alessandro Reali , Alvaro L. G. A. Coutinho

We present an approach to studying and predicting the spatio-temporal progression of infectious diseases. We treat the problem by adopting a partial differential equation (PDE) version of the Susceptible, Infected, Recovered, Deceased…

Biological Physics · Physics 2021-04-30 Zhenlin Wang , Mariana Carrasco Teja , Xiaoxuan Zhang , Gregory Teichert , Krishna Garikipati

Objective: COVID-19 has spread worldwide and made a huge influence across the world. Modeling the infectious spread situation of COVID-19 is essential to understand the current condition and to formulate intervention measurements.…

Machine Learning · Computer Science 2023-06-23 Ruhan Liu , Jiajia Li , Yang Wen , Huating Li , Ping Zhang , Bin Sheng , David Dagan Feng

The recent COVID-19 pandemic has promoted vigorous scientific activity in an effort to understand, advice and control the pandemic. Data is now freely available at a staggering rate worldwide. Unfortunately, this unprecedented level of…

Applications · Statistics 2024-01-31 Yuansan Liu , Saransh Srivastava , Zuo Huang , Felisa J. Vázquez-Abad

The recent success of deep neural network models with physical constraints (so-called, Physics-Informed Neural Networks, PINNs) has led to renewed interest in the incorporation of mechanistic information in predictive models. Statisticians…

Methodology · Statistics 2025-11-20 Christopher K. Wikle , Joshua North , Giri Gopalan , Myungsoo Yoo

As of November 2020, the number of COVID-19 cases is increasing rapidly in many countries. In Europe, the virus spread slowed considerably in the late spring due to strict lockdown, but a second wave of the pandemic grew throughout the…

Quantitative Methods · Quantitative Biology 2020-11-25 Kristoffer Rypdal , Filippo Maria Bianchi , Martin Rypdal

Physics-Informed Neural Networks (PINNs) represent a groundbreaking paradigm in scientific computing, seamlessly integrating the robust framework of deep learning with fundamental physical laws. This paper meticulously applies the standard…

Numerical Analysis · Mathematics 2026-01-19 Ahmed Aberqi , Ahmed Miloudi

Standard epidemiological models for COVID-19 employ variants of compartment (SIR) models at local scales, implicitly assuming spatially uniform local mixing. Here, we examine the effect of employing more geographically detailed diffusion…

Epidemiological models with constant parameters may not capture satisfactory infection patterns in the presence of pharmaceutical and non-pharmaceutical mitigation measures during a pandemic, since infectiousness is a function of time. In…

Populations and Evolution · Quantitative Biology 2022-05-16 K. D. Olumoyin , A. Q. M. Khaliq , K. M. Furati

Current, realistic numerical simulations of the solar atmosphere reproduce observations in a statistical sense; they do not replicate observations such as a movie of solar granulation. Inversions on the other hand reproduce observations by…

Solar and Stellar Astrophysics · Physics 2025-05-09 Christoph U. Keller

We examine the age-structured SIR model, a variant of the classical Susceptible-Infected-Recovered (SIR) model of epidemic propagation, in the context of COVID-19. In doing so, we provide a theoretical basis for the model, perform an…

Optimization and Control · Mathematics 2022-03-11 Rohit Parasnis , Ryosuke Kato , Amol Sakhale , Massimo Franceschetti , Behrouz Touri