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Molecules composed of atoms exhibit properties not inherent to their constituent atoms. Similarly, meta-molecules consisting of multiple meta-atoms possess emerging features that the meta-atoms themselves do not possess. Metasurfaces…

Optics · Physics 2019-07-09 Zhaocheng Liu , Dayu Zhu , Kyu-Tae Lee , Andrew S. Kim , Lakshmi Raju , Wenshan Cai

Exascale computing holds great opportunities for molecular dynamics (MD) simulations. However, to take full advantage of the new possibilities, we must learn how to focus computational power on the discovery of complex molecular mechanisms,…

Chemical Physics · Physics 2019-01-16 Hendrik Jung , Roberto Covino , Gerhard Hummer

Identifying the entire set of complexes is essential not only to understand complex formations, but also to map the high level organisation of the cell. Computational prediction of protein complexes faces several challenges including the…

Molecular Networks · Quantitative Biology 2015-06-08 Sriganesh Srihari

In-memory database query processing frequently involves substantial data transfers between the CPU and memory, leading to inefficiencies due to Von Neumann bottleneck. Processing-in-Memory (PIM) architectures offer a viable solution to…

While machine learning offers diverse techniques suitable for exploring various medical research questions, a cohesive synergistic framework can facilitate the integration and understanding of new approaches within unified model development…

Machine Learning · Computer Science 2025-01-09 Ramtin Zargari Marandi , Anne Svane Frahm , Jens Lundgren , Daniel Dawson Murray , Maja Milojevic

Effective model and hyperparameter selection remains a major challenge in deep learning, often requiring extensive expertise and computation. While AutoML and large language models (LLMs) promise automation, current LLM-based approaches…

Machine Learning · Computer Science 2025-10-08 Mohamed Bal-Ghaoui , Mohammed Tiouti

Alignment between human brain networks and artificial models has become an active research area in vision science and machine learning. A widely adopted approach is identifying "metamers," stimuli physically different yet perceptually…

Machine Learning · Computer Science 2025-09-25 Mina Kamao , Hayato Ono , Ayumu Yamashita , Kaoru Amano , Masataka Sawayama

Computational meta-imagers synergize metamaterial hardware with advanced signal processing approaches such as compressed sensing. Recent advances in artificial intelligence (AI) are gradually reshaping the landscape of meta-imaging. Most…

Applied Physics · Physics 2022-03-04 Chloé Saigre-Tardif , Rashid Faqiri , Hanting Zhao , Lianlin Li , Philipp del Hougne

Protein-protein interactions (PPIs) are fundamental to numerous cellular processes, and their characterization is vital for understanding disease mechanisms and guiding drug discovery. While protein language models (PLMs) have demonstrated…

Database engines have historically absorbed many of the innovations in data processing, adding features to process graph data, XML, object oriented, and text among many others. In this paper, we make the case that it is time to do the same…

Deep learning architectures for supervised learning on tabular data range from simple multilayer perceptrons (MLP) to sophisticated Transformers and retrieval-augmented methods. This study highlights a major, yet so far overlooked…

Machine Learning · Computer Science 2025-02-19 Yury Gorishniy , Akim Kotelnikov , Artem Babenko

A major problem of machine-learning approaches in structural dynamics is the frequent lack of structural data. Inspired by the recently-emerging field of population-based structural health monitoring (PBSHM), and the use of transfer…

Machine Learning · Computer Science 2023-02-17 G. Tsialiamanis , N. Dervilis , D. J. Wagg , K. Worden

Membrane protein classification is a fundamental task in structural bioinformatics, critical to understanding protein functions and accelerating drug discovery. In this study, we propose MP-GCAN, a novel graph-based classification model…

Quantitative Methods · Quantitative Biology 2025-07-22 Kunyang Li , Hongfu Lou , Dinan Peng

In recent years, AI models that mine intrinsic patterns from molecular structures and protein sequences have shown promise in accelerating drug discovery. However, these methods partly lag behind real-world pharmaceutical approaches of…

Machine Learning · Computer Science 2023-10-17 Yizhen Luo , Xing Yi Liu , Kai Yang , Kui Huang , Massimo Hong , Jiahuan Zhang , Yushuai Wu , Zaiqing Nie

Deep learning is catalyzing a scientific revolution fueled by big data, accessible toolkits, and powerful computational resources, impacting many fields including protein structural modeling. Protein structural modeling, such as predicting…

Biomolecules · Quantitative Biology 2020-07-17 Wenhao Gao , Sai Pooja Mahajan , Jeremias Sulam , Jeffrey J. Gray

We demonstrate MaskSearch, a system designed to accelerate queries over databases of image masks generated by machine learning models. MaskSearch formalizes and accelerates a new category of queries for retrieving images and their…

Recent advancements in artificial intelligence (AI), particularly foundation models (FMs), have revolutionized medical image analysis, demonstrating strong zero- and few-shot performance across diverse medical imaging tasks, from…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Praveenbalaji Rajendran , Mojtaba Safari , Wenfeng He , Mingzhe Hu , Shansong Wang , Jun Zhou , Xiaofeng Yang

Unsupervised machine learning is the training of an artificial intelligence system using information that is neither classified nor labeled, with a view to modeling the underlying structure or distribution in a dataset. Since unsupervised…

Software Engineering · Computer Science 2020-03-18 Xiaoyuan Xie , Zhiyi Zhang , Tsong Yueh Chen , Yang Liu , Pak-Lok Poon , Baowen Xu

Methods from artificial intelligence (AI), in general, and machine learning, in particular, have kept conquering new territories in numerous areas of science. Most of the applications of these techniques are restricted to the classification…

Biomolecules · Quantitative Biology 2022-10-24 Kristof Takacs , Balint Varga , Viktor Farkas , Andras Perczel , Vince Grolmusz

Advances in deep learning have opened an era of abundant and accurate predicted protein structures; however, similar progress in protein ensembles has remained elusive. This review highlights several recent research directions towards…

Biomolecules · Quantitative Biology 2025-09-23 Bowen Jing , Bonnie Berger , Tommi Jaakkola