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Agentic AI systems powered by Large Language Models (LLMs) as their foundational reasoning engine, are transforming clinical workflows such as medical report generation and clinical summarization by autonomously analyzing sensitive…

Multiagent Systems · Computer Science 2025-05-08 Subash Neupane , Sudip Mittal , Shahram Rahimi

Medicine is rife with high-stakes uncertainty. Doctors routinely make clinical judgments and decisions that juggle many fundamental unknowns, like predictions about what might be causing a patients' symptoms or decisions about what…

Multi-agent LLM systems consistently outperform single-agent baselines, yet practitioners still cannot predict which design works for a new task or diagnose why one fails. We argue this gap persists largely because the field lacks a…

Artificial Intelligence · Computer Science 2026-05-27 Yiming Yang , Zhuoyuan Li , Fanxiang Zeng , Hao Fu , Yue Liu

Mainstream methods for Legal Judgment Prediction (LJP) based on Pre-trained Language Models (PLMs) heavily rely on the statistical correlation between case facts and judgment results. This paradigm lacks explicit modeling of legal…

Computation and Language · Computer Science 2026-03-13 Yuzhi Liang , Lixiang Ma , Xinrong Zhu

Modeling latent clinical constructs from unconstrained clinical interactions is a unique challenge in affective computing. We present ADAPTS (Agentic Decomposition for Automated Protocol-agnostic Tracking of Symptoms), a framework for…

Artificial Intelligence · Computer Science 2026-05-07 Alexandria K. Vail , Marcelo Cicconet , Katie Aafjes-van Doorn , Ryan Maroney , Marc Aafjes

Continuing advances in Large Language Models (LLMs) in artificial intelligence offer important capacities in intuitively accessing and using medical knowledge in many contexts, including education and training as well as assessment and…

Computation and Language · Computer Science 2024-08-01 Roma Shusterman , Allison C. Waters , Shannon O`Neill , Phan Luu , Don M. Tucker

Explanations of machine learning (ML) model predictions generated by Explainable AI (XAI) techniques such as SHAP are essential for people using ML outputs for decision-making. We explore the potential of Large Language Models (LLMs) to…

Computation and Language · Computer Science 2024-12-09 Alexandra Zytek , Sara Pido , Sarah Alnegheimish , Laure Berti-Equille , Kalyan Veeramachaneni

Large Language Models (LLMs) are increasingly applied in healthcare, yet ensuring their ethical integrity and safety compliance remains a major barrier to clinical deployment. This work introduces a multi-agent refinement framework designed…

Most reported gains on agentic-LLM clinical benchmarks are often attributed to prompt engineering, yet our results suggest that larger improvements can come from architectural and engine-level design. We present MDIA, a Multi-agent…

Artificial Intelligence · Computer Science 2026-05-26 Roberto Cruz , David Rey-Blanco

Large Language Models (LLMs) demonstrate strong generalization and reasoning abilities, making them well-suited for complex decision-making tasks such as medical consultation (MC). However, existing LLM-based methods often fail to capture…

Computation and Language · Computer Science 2025-10-13 Zhihao Jia , Mingyi Jia , Junwen Duan , Jianxin Wang

Clinical dialogue represents a complex duality requiring both the empathetic fluency of natural conversation and the rigorous precision of evidence-based medicine. While Large Language Models possess unprecedented linguistic capabilities,…

Other Quantitative Biology · Quantitative Biology 2025-12-02 Xiaoquan Zhi , Hongke Zhao , Likang Wu , Chuang Zhao , Hengshu Zhu

Background: Structured information extraction from unstructured histopathology reports facilitates data accessibility for clinical research. Manual extraction by experts is time-consuming and expensive, limiting scalability. Large language…

Augmented Language Models (ALMs) blend the reasoning capabilities of Large Language Models (LLMs) with tools that allow for knowledge retrieval and action execution. Existing ALM systems trigger LLM thought processes while pulling…

Computation and Language · Computer Science 2023-05-31 Binfeng Xu , Zhiyuan Peng , Bowen Lei , Subhabrata Mukherjee , Yuchen Liu , Dongkuan Xu

Large language model (LLM) web agents are increasingly used for web navigation but remain far from human reliability on realistic, long-horizon tasks. Existing evaluations focus primarily on end-to-end success, offering limited insight into…

Artificial Intelligence · Computer Science 2026-04-29 Mohamed Aghzal , Gregory J. Stein , Ziyu Yao

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

Estimating individualized treatment effects from observational data presents a persistent challenge due to unmeasured confounding and structural bias. Causal Machine Learning (causal ML) methods, such as causal trees and doubly robust…

Machine Learning · Computer Science 2025-08-12 Po-Han Lee , Yu-Cheng Lin , Chan-Tung Ku , Chan Hsu , Pei-Cing Huang , Ping-Hsun Wu , Yihuang Kang

Proactive large language model (LLM) agents aim to actively plan, query, and interact over multiple turns, enabling efficient task completion beyond passive instruction following and making them essential for real-world, user-centric…

Artificial Intelligence · Computer Science 2026-02-13 Yihang Yao , Zhepeng Cen , Haohong Lin , Shiqi Liu , Zuxin Liu , Jiacheng Zhu , Zhang-Wei Hong , Laixi Shi , Ding Zhao

Complex medical reasoning has historically required frontier language models to achieve clinically-acceptable accuracy, creating computational barriers that limit deployment in resource-constrained clinical settings. We present…

Artificial Intelligence · Computer Science 2026-04-01 Pranav Pushkar Mishra , Mohammad Arvan , Mohan Zalake

We present MedPI, a high-dimensional benchmark for evaluating large language models (LLMs) in patient-clinician conversations. Unlike single-turn question-answer (QA) benchmarks, MedPI evaluates the medical dialogue across 105 dimensions…

Computation and Language · Computer Science 2026-01-09 Diego Fajardo V. , Oleksii Proniakin , Victoria-Elisabeth Gruber , Razvan Marinescu

We present MedCOD (Medical Chain-of-Dictionary), a hybrid framework designed to improve English-to-Spanish medical translation by integrating domain-specific structured knowledge into large language models (LLMs). MedCOD integrates…

Computation and Language · Computer Science 2025-09-22 Md Shahidul Salim , Lian Fu , Arav Adikesh Ramakrishnan , Zonghai Yao , Hong Yu