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A variety of models for the membrane-mediated interaction of particles in lipid membranes, mostly well-established in theoretical physics, is reviewed from a mathematical perspective. We provide mathematically consistent formulations in a…

Analysis of PDEs · Mathematics 2016-06-29 Charles M. Elliott , Carsten Gräser , Graham Hobbs , Ralf Kornhuber , Maren-Wanda Wolf

This study theoretically investigates how anisotropic curved membrane components (CMCs) control vesicle morphology through curvature sensing, nematic alignment, topological defects, and volume constraints. By comparing arc-shaped and…

Soft Condensed Matter · Physics 2025-06-18 Yoav Ravid , Samo Penič , Luka Mesarec , Nir S. Gov , Veronika Kralj-Iglič , Aleš Iglič , Mitja Drab

Multicomponent vesicles suspended in viscoelastic fluids are crucial for understanding a variety of physiological processes. In this work, we develop a continuum surface force (CSF) phase-field model to investigate the hydrodynamics of…

Fluid Dynamics · Physics 2025-12-30 Zuowei Wen , Navid Valizadeh , Timon Rabczuk , Xiaoying Zhuang

The aim of this paper is to propose a new numerical model to simulate 2D vesicles interacting with a newtonian fluid. The inextensible membrane is modeled by a chain of circular rigid particles which are maintained in cohesion by using two…

Mathematical Physics · Physics 2012-02-15 Mourad Ismail , Aline Lefebvre-Lepot

We develop coarse-grained particle approaches for studying the elastic mechanics of vesicles with heterogeneous membranes having phase-separated domains. We perform simulations both of passive shape fluctuations and of active systems where…

Soft Condensed Matter · Physics 2023-02-28 David A. Rower , Paul J. Atzberger

Motivated by the increasing interest in the properties of multimode optomechanical devices, here we study a system in which a driven mode of a large-area optical cavity is despersively coupled to a deformable mechanical element. Two…

The form and evolution of multi-phase biomembranes is of fundamental importance in order to understand living systems. In order to describe these membranes, we consider a mathematical model based on a Canham--Helfrich--Evans two-phase…

Numerical Analysis · Mathematics 2021-07-20 Harald Garcke , Robert Nürnberg

We investigate theoretically the extension of cavity optomechanics to multiple membrane systems. We describe such a system in terms of the coupling of the collective normal modes of the membrane array to the light fields. We show these…

Quantum Physics · Physics 2009-11-13 M. Bhattacharya , P. Meystre

A transient analysis for vesicle deformation under DC electric fields is developed. The theory extends from a droplet model, with the additional consideration of a lipid membrane separating two fluids of arbitrary properties. For the…

Biological Physics · Physics 2015-06-12 Jia Zhang , Jeffery D. Zahn , Wenchang Tan , Hao Lin

We study the structure and phase behavior of a binary mixture where one of the components is self-propelling in nature. The inter-particle interactions in the system were taken from the Asakura-Oosawa model, for colloid-polymer mixtures,…

Statistical Mechanics · Physics 2015-06-17 Subir K. Das , Sergei Egorov , Benjamin Trefz , Peter Virnau , Kurt Binder

Eukaryote cells have a flexible shape, which dynamically changes according to the function performed by the cell. One mechanism for deforming the cell membrane into the desired shape is through the expression of curved membrane proteins.…

Biological Physics · Physics 2018-12-05 Miha Fošnarič , Samo Penič , Aleš Iglič , Veronika Kralj-Iglič , Mitja Drab , Nir Gov

Biological cells utilize membranes and liquid-like droplets, known as biomolecular condensates, to structure their interior. The interaction of droplets and membranes, despite being involved in several key biological processes, is so far…

Soft Condensed Matter · Physics 2024-02-21 Marcel Mokbel , Dominic Mokbel , Susanne Liese , Christoph A. Weber , Sebastian Aland

Lipid membranes, the barrier defining living cells and many of their sub-compartments, bind to a wide variety of nano- and micro-meter sized objects. In the presence of strong adhesive forces, membranes can strongly deform and wrap the…

A microfluidic device is constructed from PDMS with a single channel having a short section that is a thin flexible membrane, in order to investigate the complex fluid-structure interaction that arises between a flowing fluid and a…

Soft Condensed Matter · Physics 2020-07-03 Debadi Chakraborty , J. Ravi Prakash , Leslie Yeo , James Friend

We present a general and systematic theory of non-equilibrium dynamics of multi-component fluid membranes, in general, and membranes containing transmembrane proteins, in particular. Developed based on a minimal number of principles of…

Soft Condensed Matter · Physics 2009-11-10 Michael A. Lomholt , Per L. Hansen , Ling Miao

Lipid membranes are abundant in living organisms, where they constitute a surrounding shell for cells and their organelles. There are many circumstances in which the deformations of lipid membranes are involved in living cells: fusion and…

Soft Condensed Matter · Physics 2022-11-17 Konstantin V. Pinigin

The dynamics of a membrane is a coupled system comprising a moving elastic surface and an incompressible membrane fluid. We will consider a reduced elastic surface model, which involves the evolution equations of the moving surface, the…

Analysis of PDEs · Mathematics 2015-05-27 Wei Wang , Pingwen Zhang , Zhifei Zhang

The shape deformation of a three-dimensional axisymmetric vesicle with encapsulated filaments or impurities is analyzed by integrating a dissipation dynamics. This method can incorporate systematically the constraint of a fixed surface area…

Soft Condensed Matter · Physics 2009-11-07 Akiyoshi shibuya , Yukio Saito , Hiroyuki Hyuga

We present a generic framework for modelling three-dimensional deformable shells of active matter that captures the orientational dynamics of the active particles and hydrodynamic interactions on the shell and with the surrounding…

Soft Condensed Matter · Physics 2019-11-20 Luuk Metselaar , Julia M. Yeomans , Amin Doostmohammadi

In active matter systems, deformable boundaries provide a mechanism to organize internal active stresses and perform work on the external environment. To study a minimal model of such a system, we perform particle-based simulations of an…

Soft Condensed Matter · Physics 2022-01-05 Matthew S. E. Peterson , Aparna Baskaran , Michael F. Hagan