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We propose TG-LMM (Text-Guided Large Multi-Modal Model), a novel approach that leverages textual descriptions of organs to enhance segmentation accuracy in medical images. Existing medical image segmentation methods face several challenges:…

Computer Vision and Pattern Recognition · Computer Science 2024-09-06 Yihao Zhao , Enhao Zhong , Cuiyun Yuan , Yang Li , Man Zhao , Chunxia Li , Jun Hu , Chenbin Liu

Automatic evaluation of the retinal fundus image is emerging as one of the most important tools for early detection and treatment of progressive eye diseases like Glaucoma. Glaucoma results to a progressive degeneration of vision and is…

Image and Video Processing · Electrical Eng. & Systems 2021-12-13 Sneha Dasgupta , Rishav Mukherjee , Kaushik Dutta , Anindya Sen

Retinal Optical Coherence Tomography (OCT), a noninvasive cross-sectional scan of the eye with qualitative 3D visualization of the retinal anatomy is use to study the retinal structure and the presence of pathogens. The advent of the…

Image and Video Processing · Electrical Eng. & Systems 2023-02-28 Nchongmaje Ndipenoch , Alina Miron , Zidong Wang , Yongmin Li

Training deep learning models for corneal optical coherence tomography (OCT) imaging is limited by the availability of large, well-annotated datasets. We present a configurable Monte Carlo simulation framework that generates synthetic…

Image and Video Processing · Electrical Eng. & Systems 2026-02-04 Jinglun Yu , Yaning Wang , Rosalinda Xiong , Ziyi Huang , Kristina Irsch , Jin U. Kang

Many eye diseases like Diabetic Macular Edema (DME), Age-related Macular Degeneration (AMD), and Glaucoma manifest in the retina, can cause irreversible blindness or severely impair the central version. The Optical Coherence Tomography…

Image and Video Processing · Electrical Eng. & Systems 2023-03-10 Nchongmaje Ndipenoch , Alina Miron , Zidong Wang , Yongmin Li

Accurate symptom-to-disease classification and clinically grounded treatment recommendations remain challenging, particularly in heterogeneous patient settings with high diagnostic risk. Existing large language model (LLM)-based systems…

This paper attacks an emerging challenge of multi-modal retinal disease recognition. Given a multi-modal case consisting of a color fundus photo (CFP) and an array of OCT B-scan images acquired during an eye examination, we aim to build a…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Xirong Li , Yang Zhou , Jie Wang , Hailan Lin , Jianchun Zhao , Dayong Ding , Weihong Yu , Youxin Chen

Glaucoma is one of the most severe eye diseases, characterized by rapid progression and leading to irreversible blindness. It is often the case that diagnostics is carried out when one's sight has already significantly degraded due to the…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Ahmed Al Mahrooqi , Dmitrii Medvedev , Rand Muhtaseb , Mohammad Yaqub

Both medical care and observational studies in oncology require a thorough understanding of a patient's disease progression and treatment history, often elaborately documented in clinical notes. Despite their vital role, no current oncology…

Computation and Language · Computer Science 2024-03-18 Madhumita Sushil , Vanessa E. Kennedy , Divneet Mandair , Brenda Y. Miao , Travis Zack , Atul J. Butte

Current Large Language Models (LLMs) exhibit significant limitations, notably in structured, interpretable, and verifiable medical reasoning, alongside practical deployment challenges related to computational resources and data privacy.…

Computation and Language · Computer Science 2025-06-06 Boqin Zhuang , Chenxiao Song , Huitong Lu , Jiacheng Qiao , Mingqian Liu , Mingxing Yu , Ping Hong , Rui Li , Xiaoxia Song , Xiangjun Xu , Xu Chen , Yaoyao Ma , Yujie Gao

Retinal diseases are a leading cause of vision impairment and blindness, with timely diagnosis being critical for effective treatment. Optical Coherence Tomography (OCT) has become a standard imaging modality for retinal disease diagnosis,…

Image and Video Processing · Electrical Eng. & Systems 2025-10-06 Jilan Cheng , Guoli Long , Zeyu Zhang , Zhenjia Qi , Hanyu Wang , Libin Lu , Shuihua Wang , Yudong Zhang , Jin Hong

A resolution enhancement technique for optical coherence tomography (OCT), based on Generative Adversarial Networks (GANs), was developed and investigated. GANs have been previously used for resolution enhancement of photography and optical…

Image and Video Processing · Electrical Eng. & Systems 2021-01-19 Kaicheng Liang , Xinyu Liu , Si Chen , Jun Xie , Wei Qing Lee , Linbo Liu , Hwee Kuan Lee

Diabetic Retinopathy (DR) is a leading cause of preventable blindness among working-age adults worldwide, yet most automated screening systems are limited to image-level classification and lack clinically structured reporting. We propose…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Abdelrahman Zaian , Sheethal Bhat , Mohamed Abdalkader , Andreas Maier

Large language models (LLMs) show promise for supporting clinical decision-making in complex fields such as rheumatology. Our evaluation shows that smaller language models (SLMs), combined with retrieval-augmented generation (RAG), achieve…

Computation and Language · Computer Science 2025-07-11 Sabine Felde , Rüdiger Buchkremer , Gamal Chehab , Christian Thielscher , Jörg HW Distler , Matthias Schneider , Jutta G. Richter

Background: Manual extraction of pancreatic cystic lesion (PCL) features from radiology reports is labor-intensive, limiting large-scale studies needed to advance PCL research. Purpose: To develop and evaluate large language models (LLMs)…

Alterations in retinal layer thickness, measurable using Optical Coherence Tomography (OCT), have been associated with neurodegenerative diseases such as Alzheimer's disease (AD). While previous studies have mainly focused on segmented…

Computer Vision and Pattern Recognition · Computer Science 2025-11-10 Yasemin Turkan , F. Boray Tek , M. Serdar Nazlı , Öykü Eren

Glaucoma is a progressive optic neuropathy characterized by structural damage to the optic nerve head and functional changes in the visual field. Detecting glaucoma early is crucial to preventing loss of eyesight. However, medical datasets…

Image and Video Processing · Electrical Eng. & Systems 2024-12-09 Youssof Nawar , Nouran Soliman , Moustafa Wassel , Mohamed ElHabebe , Noha Adly , Marwan Torki , Ahmed Elmassry , Islam Ahmed

Radiology report generation (RRG) models typically focus on individual exams, often overlooking the integration of historical visual or textual data, which is crucial for patient follow-ups. Traditional methods usually struggle with long…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Tengfei Liu , Jiapu Wang , Yongli Hu , Mingjie Li , Junfei Yi , Xiaojun Chang , Junbin Gao , Baocai Yin

In this paper, we propose a framework that incorporates experts diagnostics and insights into the analysis of Optical Coherence Tomography (OCT) using multi-modal learning. To demonstrate the effectiveness of this approach, we create a…

Image and Video Processing · Electrical Eng. & Systems 2022-03-22 Y. Logan , K. Kokilepersaud , G. Kwon , G. AlRegib , C. Wykoff , H. Yu

As current computing capabilities increase, modern machine learning and computer vision system tend to increase in complexity, mostly by means of larger models and advanced optimization strategies. Although often neglected, in many problems…

Image and Video Processing · Electrical Eng. & Systems 2024-06-07 Adrian Galdran , Miguel A. González Ballester