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Purpose: (1) To develop a deep learning algorithm to identify major tissue structures of the optic nerve head (ONH) in 3D optical coherence tomography (OCT) scans; (2) to exploit such information to robustly differentiate among healthy,…

Large Language Models (LLMs) show potential for medical applications but often lack specialized clinical knowledge. Retrieval Augmented Generation (RAG) allows customization with domain-specific information, making it suitable for…

Optical Coherence Tomography (OCT) is a novel and effective screening tool for ophthalmic examination. Since collecting OCT images is relatively more expensive than fundus photographs, existing methods use multi-modal learning to complement…

Image and Video Processing · Electrical Eng. & Systems 2023-08-02 Lehan Wang , Weihang Dai , Mei Jin , Chubin Ou , Xiaomeng Li

Glaucoma is a chronic visual disease that may cause permanent irreversible blindness. Measurement of the cup-to-disc ratio (CDR) plays a pivotal role in the detection of glaucoma in its early stage, preventing visual disparities. Therefore,…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Rukhshanda Hussain , Hritam Basak

Objective: To evaluate the efficiency of large language models (LLMs) such as ChatGPT to assist in diagnosing neuro-ophthalmic diseases based on detailed case descriptions. Methods: We selected 22 different case reports of neuro-ophthalmic…

Computers and Society · Computer Science 2023-09-25 Yeganeh Madadi , Mohammad Delsoz , Priscilla A. Lao , Joseph W. Fong , TJ Hollingsworth , Malik Y. Kahook , Siamak Yousefi

Large Language Models (LLMs) have shown significant promise across various natural language processing tasks. However, their application in the field of pathology, particularly for extracting meaningful insights from unstructured medical…

Computation and Language · Computer Science 2025-03-04 Rachit Saluja , Jacob Rosenthal , Yoav Artzi , David J. Pisapia , Benjamin L. Liechty , Mert R. Sabuncu

Objective Renal cancer is a common malignancy and a major cause of cancer-related deaths. Computed tomography (CT) is central to early detection, staging, and treatment planning. However, the growing CT workload increases radiologists'…

Image and Video Processing · Electrical Eng. & Systems 2025-10-17 Renjie Liang , Zhengkang Fan , Jinqian Pan , Chenkun Sun , Bruce Daniel Steinberg , Russell Terry , Jie Xu

Artificial Intelligence (AI) is necessary to address the large and growing deficit in retina and healthcare access globally. And mobile AI diagnostic platforms running in the Cloud may effectively and efficiently distribute such AI…

Writing radiology reports from medical images requires a high level of domain expertise. It is time-consuming even for trained radiologists and can be error-prone for inexperienced radiologists. It would be appealing to automate this task…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Yuzhe Lu , Sungmin Hong , Yash Shah , Panpan Xu

Glaucoma remains among the leading causes of blindness despite many treatment options available today. Effective treatment requires early diagnosis, which is difficult to achieve with existing imaging technologies that detect the already…

Objective Structured Clinical Examinations (OSCEs) are widely used to assess medical students' communication skills, but scoring interview-based assessments is time-consuming and potentially subject to human bias. This study explored the…

Computation and Language · Computer Science 2025-05-16 Jadon Geathers , Yann Hicke , Colleen Chan , Niroop Rajashekar , Justin Sewell , Susannah Cornes , Rene F. Kizilcec , Dennis Shung

Optical Coherence Tomography (OCT) is the primary imaging modality for detecting pathological biomarkers associated to retinal diseases such as Age-Related Macular Degeneration. In practice, clinical diagnosis and treatment strategies are…

Computer Vision and Pattern Recognition · Computer Science 2019-07-17 Thomas Kurmann , Pablo Márquez-Neila , Siqing Yu , Marion Munk , Sebastian Wolf , Raphael Sznitman

Extracting structured information from clinical notes requires navigating a dense web of interdependent variables where the value of one attribute logically constrains others. Existing Large Language Model (LLM)-based extraction pipelines…

Glaucoma is a serious ocular disorder for which the screening and diagnosis are carried out by the examination of the optic nerve head (ONH). The color fundus image (CFI) is the most common modality used for ocular screening. In CFI, the…

Image and Video Processing · Electrical Eng. & Systems 2019-02-05 Sharath M Shankaranarayana , Keerthi Ram , Kaushik Mitra , Mohanasankar Sivaprakasam

Question: What is the performance and reasoning ability of OpenAI o1 compared to other large language models in addressing ophthalmology-specific questions? Findings: This study evaluated OpenAI o1 and five LLMs using 6,990 ophthalmological…

Recent advances in multimodal large language models enable new possibilities for image-based decision support. However, their reliability and operational trade-offs in neuroimaging remain insufficiently understood. We present a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Katarina Trojachanec Dineva , Stefan Andonov , Ilinka Ivanoska , Ivan Kitanovski , Sasho Gramatikov , Tamara Kostova , Monika Simjanoska Misheva , Kostadin Mishev

Large Language Models (LLMs) have emerged as transformative tools in the healthcare sector, demonstrating remarkable capabilities in natural language understanding and generation. However, their proficiency in numerical reasoning,…

Artificial Intelligence · Computer Science 2025-01-27 Arjun R. Malghan

Despite the potential of Large Language Models (LLMs) in medicine, they may generate responses lacking supporting evidence or based on hallucinated evidence. While Retrieval Augment Generation (RAG) is popular to address this issue, few…

Objective: To evaluate large language models (LLMs) against supervised baselines for fine-grained, lesion-level detection of incidentalomas requiring follow-up, addressing the limitations of current document-level classification systems.…

Computation and Language · Computer Science 2025-12-08 Namu Park , Farzad Ahmed , Zhaoyi Sun , Kevin Lybarger , Ethan Breinhorst , Julie Hu , Ozlem Uzuner , Martin Gunn , Meliha Yetisgen

Purpose: To develop and evaluate an automated system for extracting structured clinical information from unstructured radiology and pathology reports using open-weights large language models (LMs) and retrieval augmented generation (RAG),…