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Clinical trial matching is a key process in health delivery and discovery. In practice, it is plagued by overwhelming unstructured data and unscalable manual processing. In this paper, we conduct a systematic study on scaling clinical trial…

Large language models (LLMs) show promise in drafting responses to patient portal messages, yet their integration into clinical workflows raises various concerns, including whether they would actually save clinicians time and effort in…

Computation and Language · Computer Science 2026-01-19 Parker Seegmiller , Joseph Gatto , Sarah E. Greer , Ganza Belise Isingizwe , Rohan Ray , Timothy E. Burdick , Sarah Masud Preum

Effective patient-provider communication is crucial in clinical care, directly impacting patient outcomes and quality of life. Traditional evaluation methods, such as human ratings, patient feedback, and provider self-assessments, are often…

Computation and Language · Computer Science 2024-09-25 Zhiyuan Wang , Fangxu Yuan , Virginia LeBaron , Tabor Flickinger , Laura E. Barnes

Large Language Models (LLMs) have seen great advance in both academia and industry, and their popularity results in numerous open-source frameworks and techniques in accelerating LLM pre-training, fine-tuning, and inference. Training and…

Performance · Computer Science 2023-12-04 Longteng Zhang , Xiang Liu , Zeyu Li , Xinglin Pan , Peijie Dong , Ruibo Fan , Rui Guo , Xin Wang , Qiong Luo , Shaohuai Shi , Xiaowen Chu

Large language models (LLMs) have been widely adopted due to their remarkable performance across various applications, driving the accelerated development of a large number of diverse models. However, these individual LLMs show limitations…

Computation and Language · Computer Science 2025-06-13 Kaushal Kumar Maurya , KV Aditya Srivatsa , Ekaterina Kochmar

Time series anomaly detection is critical for supply chain management to take proactive operations, but faces challenges: classical unsupervised anomaly detection based on exploiting data patterns often yields results misaligned with…

Machine Learning · Computer Science 2026-01-28 Haoting Zhang , Shekhar Jain

Greater capabilities of mobile communications technology enable interconnection of on-site medical care at a scale previously unavailable. However, embedding such critical, demanding tasks into the already complex infrastructure of mobile…

Machine Learning · Computer Science 2022-01-26 Steffen Gracla , Edgar Beck , Carsten Bockelmann , Armin Dekorsy

Business optimisation has been used extensively to determine optimal solutions for challenging business operations. Problem formulation is an important part of business optimisation as it influences both the validity of solutions and the…

Artificial Intelligence · Computer Science 2025-04-23 Pivithuru Thejan Amarasinghe , Su Nguyen , Yuan Sun , Damminda Alahakoon

This work presents an analytical framework for the design and analysis of LLM-based algorithms, i.e., algorithms that contain one or multiple calls of large language models (LLMs) as sub-routines and critically rely on the capabilities of…

Machine Learning · Computer Science 2025-10-14 Yanxi Chen , Yaliang Li , Bolin Ding , Jingren Zhou

The rapid adoption of large language models (LLMs) in healthcare has been accompanied by scrutiny of their oversight. Existing monitoring approaches, inherited from traditional machine learning (ML), are task-based and founded on assumed…

Artificial Intelligence · Computer Science 2025-11-06 Katherine C. Kellogg , Bingyang Ye , Yifan Hu , Guergana K. Savova , Byron Wallace , Danielle S. Bitterman

Recent advancements in tool learning have enabled large language models (LLMs) to integrate external tools, enhancing their task performance by expanding their knowledge boundaries. However, relying on tools often introduces tradeoffs…

Computation and Language · Computer Science 2025-03-11 Hongshen Xu , Zihan Wang , Zichen Zhu , Lei Pan , Xingyu Chen , Lu Chen , Kai Yu

The introduction of Large Language Models (LLMs), and the vast volume of publicly available medical data, amplified the application of NLP to the medical domain. However, LLMs are pretrained on data that are not explicitly relevant to the…

Computation and Language · Computer Science 2023-12-12 Chris Solomou

Contemporary large language models (LLMs) may have utility for processing unstructured, narrative free-text clinical data contained in electronic health records (EHRs) -- a particularly important use-case for mental health where a majority…

Artificial Intelligence · Computer Science 2024-04-01 Niall Taylor , Andrey Kormilitzin , Isabelle Lorge , Alejo Nevado-Holgado , Dan W Joyce

Large Language Model (LLM) inference, where a trained model generates text one word at a time in response to user prompts, is a computationally intensive process requiring efficient scheduling to optimize latency and resource utilization. A…

Machine Learning · Computer Science 2026-01-16 Patrick Jaillet , Jiashuo Jiang , Konstantina Mellou , Marco Molinaro , Chara Podimata , Zijie Zhou

Large Language Models (LLMs) have revolutionized various fields, yet their training efficiency is heavily reliant on effective data curation. While data selection has been widely studied, the strategic data organization for enhanced…

Artificial Intelligence · Computer Science 2026-05-29 Yalun Dai , Yangyu Huang , Tongshen Yang , Yonghan Wang , Xin Zhang , Wenshan Wu , Qihao Zhao , Hao Li , Yuanyuan Gao , Kim-Hui Yap , Scarlett Li

Recently there has been a surge of interest in operations research (OR) and the machine learning (ML) community in combining prediction algorithms and optimization techniques to solve decision-making problems in the face of uncertainty.…

Optimization and Control · Mathematics 2025-11-11 Utsav Sadana , Abhilash Chenreddy , Erick Delage , Alexandre Forel , Emma Frejinger , Thibaut Vidal

Modeling & Simulation (M&S) approaches such as agent-based models hold significant potential to support decision-making activities in health, with recent examples including the adoption of vaccines, and a vast literature on healthy eating…

Artificial Intelligence · Computer Science 2025-09-08 Philippe J. Giabbanelli , Ameeta Agrawal

Large language models (LLMs) show promise for improving the efficiency of qualitative analysis in large, multi-site health-services research. Yet methodological guidance for LLM integration into qualitative analysis and evidence of their…

Computation and Language · Computer Science 2026-01-22 Sasha Ronaghi , Emma-Louise Aveling , Maria Levis , Rachel Lauren Ross , Emily Alsentzer , Sara Singer

Optimization models developed by operations research (OR) experts are often deployed as decision-support systems in industrial settings. However, real-world environments are dynamic, with evolving business rules and unforeseen…

Artificial Intelligence · Computer Science 2026-05-28 Tinghan Ye , Arnaud Deza , Ved Mohan , El Mehdi Er Raqabi , Pascal Van Hentenryck

Large Language Model (LLM) inference systems present significant challenges in statistical performance characterization due to dynamic workload variations, diverse hardware architectures, and complex interactions between model size, batch…

Performance · Computer Science 2025-05-15 Kaustabha Ray , Nelson Mimura Gonzalez , Bruno Wassermann , Rachel Tzoref-Brill , Dean H. Lorenz