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The Quadratic Unconstrained Binary Optimization problem (QUBO) has become a unifying model for representing a wide range of combinatorial optimization problems, and for linking a variety of disciplines that face these problems. A new class…

Artificial Intelligence · Computer Science 2017-05-30 Mark Lewis , Fred Glover

Quadratic unconstrained binary optimization (QUBO) problems are well-studied, not least because they can be approached using contemporary quantum annealing or classical hardware acceleration. However, due to limited precision and hardware…

Quantum Physics · Physics 2023-07-06 Sascha Mücke , Thore Gerlach , Nico Piatkowski

Quantum annealing aims at solving optimization problems of practical relevance using quantum-computing hardware. Problems of interest are typically formulated in terms of quadratic unconstrained binary optimization (QUBO) Hamiltonians.…

Current quantum annealing experiments often suffer from restrictions in connectivity in the sense that only certain qubits can be coupled to each other. The most common strategy to overcome connectivity restrictions so far is by combining…

We apply a new approach to the reverse protein folding problem. Our method uses a minimization function in the design process which is different from the energy function used for folding. For a lattice model, we show that this new approach…

Condensed Matter · Physics 2009-10-28 J. M. Deutsch , Tanya Kurosky

Quantum computers promise a qualitative speedup in solving a broad spectrum of practical optimization problems. The latter can be mapped onto the task of finding low-energy states of spin glasses, which is known to be exceedingly difficult.…

Disordered Systems and Neural Networks · Physics 2024-12-31 Hao Zhang , Kelly Boothby , Alex Kamenev

We aim to advance the state-of-the-art in Quadratic Unconstrained Binary Optimization formulation with a focus on cryptography algorithms. As the minimal QUBO encoding of the linear constraints of optimization problems emerges as the…

Cryptography and Security · Computer Science 2026-04-16 Gregory Morse , Tamás Kozsik , Oskar Mencer , Peter Rakyta

Quadratic unconstrained binary optimization (QUBO) is the mathematical formalism for phrasing and solving a class of optimization problems that are combinatorial in nature. Due to their natural equivalence with the two dimensional Ising…

Optimization or sampling of arbitrary pairwise Ising models, in a quantum annealing protocol of constrained interaction topology, can be enabled by a minor-embedding procedure. The logical problem of interest is transformed to a physical…

Quantum Physics · Physics 2021-05-20 Jack Raymond , Ndiamé Ndiaye , Gautam Rayaprolu , Andrew King

Sampling equilibrium ensembles of dense polymer mixtures is a paradigmatically hard problem in computational physics, even in lattice-based models. Here, we develop a formalism based on interacting binary tensors that allows for tackling…

Soft Condensed Matter · Physics 2021-08-25 Cristian Micheletti , Philipp Hauke , Pietro Faccioli

Quantum annealing technologies aim to solve computational optimization and sampling problems. QPU (Quantum Processing Unit) machines such as the D-Wave system use the QUBO (Quadratic Unconstrained Binary Optimization) formula to define…

Quantum Physics · Physics 2022-03-28 Toufan D. Tambunan , Andriyan B. Suksmono , Ian J. M. Edward , Rahmat Mulyawan

We introduce a qubit- and gate-efficient higher-order unconstrained binary optimization (HUBO) encoding for graph partitioning problems requiring label-count minimization. This widely applicable class of problems includes minimum graph…

Quantum processing units (QPUs) executing annealing algorithms have shown promise in optimization and simulation applications. Hybrid algorithms are a natural bridge to additional applications of larger scale. We present a straightforward…

Modern quantum annealers can find high-quality solutions to combinatorial optimisation objectives given as quadratic unconstrained binary optimisation (QUBO) problems. Unfortunately, obtaining suitable QUBO forms in computer vision remains…

Operation management of nuclear power plants consists of several computationally hard problems. Searching for an in-core fuel loading pattern is among them. The main challenge of this combinatorial optimization problem is the exponential…

We study the protein folding problem on the base of the quantum approach we proposed recently by considering the model of protein chain with nine amino-acid residues. We introduced the concept of distance space and its projections on a…

Biological Physics · Physics 2021-06-24 Wen-Wen Mao , Li-Hua Lu , Yong-Yun Ji , You-Quan Li

Recent advances in quantum technology have led to the development and manufacturing of experimental programmable quantum annealers that promise to solve certain combinatorial optimization problems of practical relevance faster than their…

Quantum Physics · Physics 2016-05-31 Itay Hen , Federico M. Spedalieri

Compact lattice Quantum Electrodynamics is a complex quantum field theory with dynamical gauge and matter fields and it has similarities with Quantum Chromodynamics, in particular asymptotic freedom and confinement. We consider a…

High Energy Physics - Lattice · Physics 2024-12-11 Arianna Crippa , Karl Jansen , Enrico Rinaldi

Quantum Annealing (QA) can be used to quickly obtain near-optimal solutions for Quadratic Unconstrained Binary Optimization (QUBO) problems. In QA hardware, each decision variable of a QUBO should be mapped to one or more adjacent qubits in…

Data Structures and Algorithms · Computer Science 2021-01-21 Thiago Serra , Teng Huang , Arvind Raghunathan , David Bergman

Uncertainty is fundamental in modern power systems, where renewable generation and fluctuating demand make stochastic optimization indispensable. The chance constrained unit commitment problem (UCP) captures this uncertainty but rapidly…

Quantum Physics · Physics 2025-12-04 David Ribes , Tatiana Gonzalez Grandon