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Latent Diffusion Models (LDMs) rely heavily on the compressed latent space provided by Variational Autoencoders (VAEs) for high-quality image generation. Recent studies have attempted to obtain generation-friendly VAEs by directly adopting…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 John Page , Xuesong Niu , Kai Wu , Kun Gai

Recent work leverages Vision Foundation Models as image encoders to boost the generative performance of latent diffusion models (LDMs), as their semantic feature distributions are easy to learn. However, such semantic features often lack…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Siyu Liu , Chujie Qin , Hubery Yin , Qixin Yan , Zheng-Peng Duan , Chen Li , Jing Lyu , Chun-Le Guo , Chongyi Li

In this project, we have explored machine learning approaches for predicting hearing loss thresholds on the brain's gray matter 3D images. We have solved the problem statement in two phases. In the first phase, we used a 3D CNN model to…

Machine Learning · Computer Science 2024-05-03 Trinath Sai Subhash Reddy Pittala , Uma Maheswara R Meleti , Manasa Thatipamula

Multi-site structural MRI is increasingly used in neuroimaging studies to diversify subject cohorts. However, combining MR images acquired from various sites/centers may introduce site-related non-biological variations. Retrospective image…

Image and Video Processing · Electrical Eng. & Systems 2024-08-20 Mengqi Wu , Minhui Yu , Shuaiming Jing , Pew-Thian Yap , Zhengwu Zhang , Mingxia Liu

Automatic segmentation of brain abnormalities is challenging, as they vary considerably from one pathology to another. Current methods are supervised and require numerous annotated images for each pathology, a strenuous task. To tackle…

Image and Video Processing · Electrical Eng. & Systems 2021-01-27 Benjamin Lambert , Maxime Louis , Senan Doyle , Florence Forbes , Michel Dojat , Alan Tucholka

Longitudinal brain MRI is essential for characterizing the progression of neurological diseases such as Alzheimer's disease assessment. However, current deep-learning tools fragment this process: classifiers reduce a scan to a label,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Zhaoyang Jiang , Zhizhong Fu , David McAllister , Yunsoo Kim , Honghan Wu

Learning efficient representations for concepts has been proven to be an important basis for many applications such as machine translation or document classification. Proper representations of medical concepts such as diagnosis, medication,…

Machine Learning · Computer Science 2016-02-18 Edward Choi , Mohammad Taha Bahadori , Elizabeth Searles , Catherine Coffey , Jimeng Sun

Melanoma represents a critical health risk due to its aggressive progression and high mortality, underscoring the need for early, interpretable diagnostic tools. While deep learning has advanced in skin lesion classification, most existing…

Computer Vision and Pattern Recognition · Computer Science 2025-07-28 Ciro Listone , Aniello Murano

Self-supervised learning has attracted increasing attention as it learns data-driven representation from data without annotations. Vision transformer-based autoencoder (ViT-AE) by He et al. (2021) is a recent self-supervised learning…

Computer Vision and Pattern Recognition · Computer Science 2023-05-17 Chinmay Prabhakar , Hongwei Bran Li , Jiancheng Yang , Suprosana Shit , Benedikt Wiestler , Bjoern Menze

Healthcare models are transitioning from unimodal prediction toward multimodal reasoning over heterogeneous diagnostic inputs. In computational pathology, for complex tumor subtypes where morphology alone can be challenging to distinguish,…

Generative models based on deep learning have shown significant potential in medical imaging, particularly for modality transformation and multimodal fusion in MRI-based brain imaging. This study introduces GM-LDM, a novel framework that…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Hu Xu , Yang Jingling , Jia Sihan , Bi Yuda , Calhoun Vince

A key advance in learning generative models is the use of amortized inference distributions that are jointly trained with the models. We find that existing training objectives for variational autoencoders can lead to inaccurate amortized…

Machine Learning · Computer Science 2018-05-31 Shengjia Zhao , Jiaming Song , Stefano Ermon

The integrative analysis of histopathological images and genomic data has received increasing attention for survival prediction of human cancers. However, the existing studies always hold the assumption that full modalities are available.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-19 Junjie Zhou , Jiao Tang , Yingli Zuo , Peng Wan , Daoqiang Zhang , Wei Shao

Lesion detection in brain Magnetic Resonance Images (MRIs) remains a challenging task. MRIs are typically read and interpreted by domain experts, which is a tedious and time-consuming process. Recently, unsupervised anomaly detection (UAD)…

Image and Video Processing · Electrical Eng. & Systems 2022-02-01 Marcel Bengs , Finn Behrendt , Max-Heinrich Laves , Julia Krüger , Roland Opfer , Alexander Schlaefer

In this paper, we propose a novel model called Learnable VAE (L-VAE), which learns a disentangled representation together with the hyperparameters of the cost function. L-VAE can be considered as an extension of \b{eta}-VAE, wherein the…

Machine Learning · Computer Science 2025-07-04 Hazal Mogultay Ozcan , Sinan Kalkan , Fatos T. Yarman-Vural

Learning Interpretable representation in medical applications is becoming essential for adopting data-driven models into clinical practice. It has been recently shown that learning a disentangled feature representation is important for a…

Machine Learning · Computer Science 2019-04-19 Mhd Hasan Sarhan , Abouzar Eslami , Nassir Navab , Shadi Albarqouni

Brain atrophy is an important biomarker for monitoring neurodegeneration and disease progression in conditions such as multiple sclerosis (MS). An accurate and robust quantitative measurement of brain volume change is paramount for…

Quantitative Methods · Quantitative Biology 2023-02-09 Geng Zhan , Dongang Wang , Mariano Cabezas , Lei Bai , Kain Kyle , Wanli Ouyang , Michael Barnett , Chenyu Wang

Latent space models are widely used for analyzing high-dimensional discrete data matrices, such as patient-feature matrices in electronic health records (EHRs), by capturing complex dependence structures through low-dimensional embeddings.…

Machine Learning · Computer Science 2026-02-19 Weijing Tang , Ming Yuan , Zongqi Xia , Tianxi Cai

We present brat (brain report alignment transformer), a multi-view representation learning framework for brain magnetic resonance imaging (MRI) trained on MRIs paired with clinical reports. Brain MRIs present unique challenges due to the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Maxime Kayser , Maksim Gridnev , Wanting Wang , Max Bain , Aneesh Rangnekar , Avijit Chatterjee , Aleksandr Petrov , Harini Veeraraghavan , Nathaniel C. Swinburne

Important applications of advancements in machine learning, are in the area of healthcare, more so for neurological disorder detection. A crucial step towards understanding the neurological status, is to estimate the brain age using…

Image and Video Processing · Electrical Eng. & Systems 2024-07-10 Vamshi Krishna Kancharla , Neelam Sinha