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Adapting a pretrained diffusion model to new objectives at inference time remains an open problem in generative modeling. Existing steering methods suffer from inaccurate value estimation, especially at high noise levels, which biases…

Machine Learning · Computer Science 2025-06-27 Vineet Jain , Kusha Sareen , Mohammad Pedramfar , Siamak Ravanbakhsh

This tutorial provides a comprehensive survey of methods for fine-tuning diffusion models to optimize downstream reward functions. While diffusion models are widely known to provide excellent generative modeling capability, practical…

Machine Learning · Computer Science 2024-07-19 Masatoshi Uehara , Yulai Zhao , Tommaso Biancalani , Sergey Levine

Diffusion models have achieved state-of-the-art performance across multiple domains, with recent advancements extending their applicability to discrete data. However, aligning discrete diffusion models with task-specific preferences remains…

Machine Learning · Computer Science 2025-04-10 Umberto Borso , Davide Paglieri , Jude Wells , Tim Rocktäschel

Diffusion models have shown promising generative capabilities across diverse domains, yet aligning their outputs with desired reward functions remains a challenge, particularly in cases where reward functions are non-differentiable. Some…

Machine Learning · Computer Science 2025-06-04 Xiner Li , Masatoshi Uehara , Xingyu Su , Gabriele Scalia , Tommaso Biancalani , Aviv Regev , Sergey Levine , Shuiwang Ji

Diffusion models have recently emerged as a powerful tool for planning. However, unlike Monte Carlo Tree Search (MCTS)-whose performance naturally improves with inference-time computation scaling-standard diffusion-based planners offer only…

Artificial Intelligence · Computer Science 2026-01-30 Jaesik Yoon , Hyeonseo Cho , Doojin Baek , Yoshua Bengio , Sungjin Ahn

This tutorial provides an in-depth guide on inference-time guidance and alignment methods for optimizing downstream reward functions in diffusion models. While diffusion models are renowned for their generative modeling capabilities,…

Artificial Intelligence · Computer Science 2025-01-22 Masatoshi Uehara , Yulai Zhao , Chenyu Wang , Xiner Li , Aviv Regev , Sergey Levine , Tommaso Biancalani

Diffusion and flow models achieve State-Of-The-Art (SOTA) generative performance, yet many practically important behaviors such as fine-grained prompt fidelity, compositional correctness, and text rendering are weakly specified by score or…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Yuanzhi Zhu , Xi Wang , Stéphane Lathuilière , Vicky Kalogeiton

Generative diffusion models for end-to-end autonomous driving often suffer from mode collapse, tending to generate conservative and homogeneous behaviors. While DiffusionDrive employs predefined anchors representing different driving…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Jialv Zou , Shaoyu Chen , Bencheng Liao , Zhiyu Zheng , Yuehao Song , Lefei Zhang , Qian Zhang , Wenyu Liu , Xinggang Wang

We address the problem of fine-tuning diffusion models for reward-guided generation in biomolecular design. While diffusion models have proven highly effective in modeling complex, high-dimensional data distributions, real-world…

Optimizing the noise samples of diffusion and flow models is an increasingly popular approach to align these models to target rewards at inference time. However, we observe that these approaches are usually restricted to differentiable or…

Machine Learning · Computer Science 2026-03-17 Niklas Schweiger , Daniel Cremers , Karnik Ram

Graph generation is a fundamental problem in graph learning with broad applications across Web-scale systems, knowledge graphs, and scientific domains such as drug and material discovery. Recent approaches leverage diffusion models for…

Machine Learning · Computer Science 2026-03-18 Jiachi Zhao , Zehong Wang , Yamei Liao , Chuxu Zhang , Yanfang Ye

High-level autonomous driving requires motion planners capable of modeling multimodal future uncertainties while remaining robust in closed-loop interactions. Although diffusion-based planners are effective at modeling complex trajectory…

Computer Vision and Pattern Recognition · Computer Science 2026-04-17 Hao Gao , Shaoyu Chen , Yifan Zhu , Yuehao Song , Wenyu Liu , Qian Zhang , Xinggang Wang

Diffusion-based planning, learning, and control methods present a promising branch of powerful and expressive decision-making solutions. Given the growing interest, such methods have undergone numerous refinements over the past years.…

Machine Learning · Computer Science 2025-02-19 Dom Huh , Prasant Mohapatra

Designing functional protein sequences that satisfy multiple desired properties is a core research focus of protein engineering. Prior methods struggle with inability or inefficiency when dealing with numerous, often conflicting,…

Biomolecules · Quantitative Biology 2026-05-08 Zitai Kong , Yifan Dong , Yixuan Wu , Zhaokang Liang , Jian Wu , Hongxia Xu

Recent studies have demonstrated the strong empirical performance of diffusion models on discrete sequences across domains from natural language to biological sequence generation. For example, in the protein inverse folding task,…

Planning with pretrained diffusion models has emerged as a promising approach for solving test-time guided control problems. Standard gradient guidance typically performs optimally under convex, differentiable reward landscapes. However, it…

Artificial Intelligence · Computer Science 2025-11-11 Hyeonseong Jeon , Cheolhong Min , Jaesik Park

Offline safe reinforcement learning often requires policies to adapt at deployment time to safety budgets that vary across episodes or change within a single episode. While diffusion-based planners enable flexible trajectory generation,…

Machine Learning · Computer Science 2026-05-06 Rufeng Chen , Zhaofan Zhang , Zhejiang Yang , Hechang Chen , Sihong Xie

Diffusion models are widely used for generative tasks across domains. Given a pre-trained diffusion model, it is often desirable to fine-tune it further either to correct for errors in learning or to align with downstream applications.…

Diffusion models have demonstrated strong generative capabilities across scientific domains, but often produce outputs that violate physical laws. We propose a new perspective by framing physics-informed generation as a sparse reward…

Machine Learning · Computer Science 2025-09-26 Mingze Yuan , Pengfei Jin , Na Li , Quanzheng Li

Recent advances in diffusion models have opened new avenues for research into embodied AI agents and robotics. Despite significant achievements in complex robotic locomotion and skills, mobile manipulation-a capability that requires the…

Robotics · Computer Science 2025-04-03 Sixu Yan , Zeyu Zhang , Muzhi Han , Zaijin Wang , Qi Xie , Zhitian Li , Zhehan Li , Hangxin Liu , Xinggang Wang , Song-Chun Zhu
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