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Related papers: KnowGuard: Knowledge-Driven Abstention for Multi-R…

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The increasing reliance on Large Language Models (LLMs) for health information seeking can pose severe risks due to the potential for misinformation and the complexity of these topics. This paper introduces KNOWNET a visualization system…

Human-Computer Interaction · Computer Science 2024-09-27 Youfu Yan , Yu Hou , Yongkang Xiao , Rui Zhang , Qianwen Wang

Large language models perform well on static medical examinations, yet clinical diagnosis often requires iterative evidence gathering under uncertainty. Building on prior interactive evaluation efforts, we introduce an OSCE-inspired…

Artificial Intelligence · Computer Science 2026-05-22 Chen Zhan , Xihe Qiu , Xiaoyu Tan , Xibing Zhuang , Gengchen Ma , Yue Zhang , Shuo Li , Peifeng Liu , Xiaoxiao Ge , Liang Liu , Lu Gan

Enabling large language models (LLMs) to appropriately abstain from answering questions beyond their knowledge is crucial for mitigating hallucinations. While existing reinforcement learning methods foster autonomous abstention, they often…

Machine Learning · Computer Science 2026-04-28 Cheng Gao , Cheng Huang , Kangyang Luo , Ziqing Qiao , Shuzheng Si , Huimin Chen , Chaojun Xiao , Maosong Sun

While LLMs have seen substantial improvement in reasoning capabilities, they also sometimes overthink, generating unnecessary reasoning steps, particularly under uncertainty, given ill-posed or ambiguous queries. We introduce statistically…

Artificial Intelligence · Computer Science 2026-02-17 Yangxinyu Xie , Tao Wang , Soham Mallick , Yan Sun , Georgy Noarov , Mengxin Yu , Tanwi Mallick , Weijie J. Su , Edgar Dobriban

Extractive reading comprehension systems are designed to locate the correct answer to a question within a given text. However, a persistent challenge lies in ensuring these models maintain high accuracy in answering questions while reliably…

Computation and Language · Computer Science 2025-04-09 Qian-Wen Zhang , Fang Li , Jie Wang , Lingfeng Qiao , Yifei Yu , Di Yin , Xing Sun

Question answering is a natural language understanding task that involves reasoning over both explicit context, and unstated relevant domain knowledge. Despite the high cost of training, large language models (LLMs) -- the backbone of most…

Computation and Language · Computer Science 2025-04-24 Laura Cabello , Carmen Martin-Turrero , Uchenna Akujuobi , Anders Søgaard , Carlos Bobed

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Large language models often generate confident but incorrect answers rather than abstaining when uncertain. This problem is particularly acute for small language models (SLMs), where computational constraints and autonomous operation…

Artificial Intelligence · Computer Science 2026-05-26 Ashwath Vaithinathan Aravindan , Mayank Kejriwal

Effective clinical history taking is a foundational yet underexplored component of clinical reasoning. While large language models (LLMs) have shown promise on static benchmarks, they often fall short in dynamic, multi-turn diagnostic…

Computation and Language · Computer Science 2026-01-30 Yang Zhou , Zhenting Sheng , Mingrui Tan , Yuting Song , Jun Zhou , Yu Heng Kwan , Lian Leng Low , Yang Bai , Yong Liu

Large language models (LLMs) achieve strong reasoning performance through chain-of-thought (CoT) reasoning, yet often generate unnecessarily long reasoning paths that incur high inference cost. Recent self-consistency-based approaches…

Computation and Language · Computer Science 2026-03-19 Juming Xiong , Kevin Guo , Congning Ni , Chao Yan , Katherine Brown , Avinash Baidya , Xiang Gao , Bradley Malin , Zhijun Yin

LLMs are increasingly deployed in high-stakes domains such as medical triage and legal assistance, often as document-grounded QA systems in which a user provides a description, relevant sources are retrieved, and an LLM generates a…

Computation and Language · Computer Science 2026-03-09 Maksym Taranukhin , Shuyue Stella Li , Evangelos Milios , Geoff Pleiss , Yulia Tsvetkov , Vered Shwartz

Interactive medical questioning is essential in real-world clinical consultations, where physicians must actively gather information from patients. While medical Large Language Models (LLMs) have shown impressive capabilities in static…

Computation and Language · Computer Science 2025-08-20 Hongxin Ding , Baixiang Huang , Yue Fang , Weibin Liao , Xinke Jiang , Zheng Li , Junfeng Zhao , Yasha Wang

Memory-augmented large language models extend reasoning beyond a fixed context window by maintaining long-term memory across interactions. However, existing memory systems often collapse stable user facts, episodic events, and behavioral…

Computation and Language · Computer Science 2026-05-28 Hyeonjeong Ha , Jeonghwan Kim , Cheng Qian , Jiayu Liu , William M. Campbell , Yue Wu , Yuji Zhang , Kathleen McKeown , Dilek Hakkani-Tur , Heng Ji

In Natural Language Processing (NLP), Machine Reading Comprehension (MRC) is the task of answering a question based on a given context. To handle questions in the medical domain, modern language models such as BioBERT, SciBERT and even…

Computation and Language · Computer Science 2024-12-16 Saptarshi Sengupta , Connor Heaton , Suhan Cui , Soumalya Sarkar , Prasenjit Mitra

Large language models (LLMs) are widely used, but they often generate subtle factual errors, especially in long-form text. These errors are fatal in some specialized domains such as medicine. Existing fact-checking with grounding documents…

Computation and Language · Computer Science 2025-05-29 Yingjian Chen , Haoran Liu , Yinhong Liu , Jinxiang Xie , Rui Yang , Han Yuan , Yanran Fu , Peng Yuan Zhou , Qingyu Chen , James Caverlee , Irene Li

The reliability of Large Language Models (LLMs) in high-stakes domains such as healthcare, law, and scientific discovery is often compromised by hallucinations. These failures typically stem from two sources: data-driven hallucinations and…

Machine Learning · Computer Science 2026-03-03 Xinyue Zeng , Junhong Lin , Yujun Yan , Feng Guo , Liang Shi , Jun Wu , Dawei Zhou

Clinical decision-making is a fundamental stage in delivering appropriate care to patients. In recent years several decision-making systems designed to aid the clinician in this process have been developed. However, technical solutions…

Computation and Language · Computer Science 2023-10-10 Rakhilya Lee Mekhtieva , Brandon Forbes , Dalal Alrajeh , Brendan Delaney , Alessandra Russo

For Large Language Models (LLMs) to be reliably deployed, models must effectively know when not to answer: abstain. Reasoning models, in particular, have gained attention for impressive performance on complex tasks. However, reasoning…

Artificial Intelligence · Computer Science 2026-04-03 Abinitha Gourabathina , Inkit Padhi , Manish Nagireddy , Subhajit Chaudhury , Prasanna Sattigeri

Large Language Models (LLMs) are being adopted at an unprecedented rate, yet still face challenges in knowledge-intensive domains like biomedicine. Solutions such as pre-training and domain-specific fine-tuning add substantial computational…