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Identifying variables associated with clinical endpoints is of much interest in clinical trials. With the rapid growth of cell and gene therapy (CGT) and therapeutics for ultra-rare diseases, there is an urgent need for statistical methods…
Computational antibody design seeks to automatically create an antibody that binds to an antigen. The binding affinity is governed by the 3D binding interface where antibody residues (paratope) closely interact with antigen residues…
Recently Transformer has shown good performance in several vision tasks due to its powerful modeling capabilities. To reduce the quadratic complexity caused by the attention, some outstanding work restricts attention to local regions or…
AlphaFold 3 (AF3) is a powerful biomolecular structure-predicting tool based on the latest deep learning algorithms and revolutionized AI model architectures. A few of papers have already investigated its accuracy in predicting different…
Network embedding represents nodes in a continuous vector space and preserves structure information from the Network. Existing methods usually adopt a "one-size-fits-all" approach when concerning multi-scale structure information, such as…
Accurate beam prediction is essential for maintaining reliable links and high spectral efficiency in dynamic low-altitude wireless networks. However, existing approaches often fail to capture the deep correlations across heterogeneous…
Graph convolutional networks (GCNs) have been widely used and achieved remarkable results in skeleton-based action recognition. We think the key to skeleton-based action recognition is a skeleton hanging in frames, so we focus on how the…
Accurate prediction of antibody-antigen binding affinity is fundamental to therapeutic design, yet remains constrained by severe label sparsity and the complexity of antigenic variations. In this paper, we propose AbLWR (Antibody-antigen…
Medical image segmentation, a crucial task in computer vision, facilitates the automated delineation of anatomical structures and pathologies, supporting clinicians in diagnosis, treatment planning, and disease monitoring. Notably,…
We consider the problem of antibody sequence design given 3D structural information. Building on previous work, we propose a fine-tuned inverse folding model that is specifically optimised for antibody structures and outperforms generic…
At present, people usually use some methods based on convolutional neural networks (CNNs) for Electroencephalograph (EEG) decoding. However, CNNs have limitations in perceiving global dependencies, which is not adequate for common EEG…
The task of 2D human pose estimation is challenging as the number of keypoints is typically large (~ 17) and this necessitates the use of robust neural network architectures and training pipelines that can capture the relevant features from…
Recent stereo matching networks achieves dramatic performance by introducing epipolar line constraint to limit the matching range of dual-view. However, in complicated real-world scenarios, the feature information based on intra-epipolar…
While the performance of face recognition systems has improved significantly in the last decade, they are proved to be highly vulnerable to presentation attacks (spoofing). Most of the research in the field of face presentation attack…
While conventional computer vision emphasizes pixel-level and feature-based objectives, medical image analysis of intricate biological structures necessitates explicit representation of their complex topological properties. Despite their…
We propose Axial Transformers, a self-attention-based autoregressive model for images and other data organized as high dimensional tensors. Existing autoregressive models either suffer from excessively large computational resource…
Accurate traffic forecasting is essential for intelligent transportation systems, supporting a wide range of real-world applications. However, it remains challenging due to two key factors:~(1) Traffic series contain heterogeneous temporal…
Many factors influence biomolecules binding, and its assessment constitutes an elusive challenge in computational structural biology. In this respect, the evaluation of shape complementarity at molecular interfaces is one of the main…
Antibody-based therapeutics-including antibody-drug conjugates (ADCs), bispecific antibodies, and novel formats-are reshaping oncology, yet key determinants of efficacy, safety, and manufacturability frequently emerge after conjugation and…
Anomaly detection (AD) plays a vital role across a wide range of domains, but its performance might deteriorate when applied to target domains with limited data. Domain Adaptation (DA) offers a solution by transferring knowledge from a…