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Compartmental models provide simple and efficient tools to analyze the relevant transmission processes during an outbreak, to produce short-term forecasts or transmission scenarios, and to assess the impact of vaccination campaigns.…

Numerical Analysis · Mathematics 2025-02-19 Caterina Millevoi , Damiano Pasetto , Massimiliano Ferronato

Reaction-diffusion epidemic models with vital dynamics are an important framework for describing the spatial and temporal spread of infectious diseases. In this work, we present a constraint-aware, physics-informed neural network (PINN)…

Dynamical Systems · Mathematics 2026-05-20 Achraf Zinihi , Matthias Ehrhardt

Accurate forecasting of contagious diseases is critical for public health policymaking and pandemic preparedness. We propose a new infectious disease forecasting model based on physics-informed neural networks (PINNs), an emerging…

Machine Learning · Computer Science 2025-04-30 Ying Qian , Kui Zhang , Éric Marty , Avranil Basu , Eamon B. O'Dea , Xianqiao Wang , Spencer Fox , Pejman Rohani , John M. Drake , He Li

This work introduces a physics-informed neural networks (PINNs)-based model predictive control (MPC) framework for susceptible-infected-recovered ($SIR$) spreading models. Existing studies in MPC design for epidemic control often assume…

Machine Learning · Computer Science 2025-09-17 Aiping Zhong , Baike She , Philip E. Paré

A physics-informed neural network (PINN) embedded with the susceptible-infected-removed (SIR) model is devised to understand the temporal evolution dynamics of infectious diseases. Firstly, the effectiveness of this approach is demonstrated…

Quantitative Methods · Quantitative Biology 2025-04-08 Shuai Han , Lukas Stelz , Horst Stoecker , Lingxiao Wang , Kai Zhou

Epidemiological modeling is vital in understanding disease dynamics and guiding public health interventions. This study presents a time-fractional SEIR model to describe the transmission dynamics of Mpox, incorporating memory effects via…

Numerical Analysis · Mathematics 2026-01-29 Gaurav Saini , Bappa Ghosh , Sunita Chand , Jugal Mohapatra

A variety of approaches using compartmental models have been used to study the COVID-19 pandemic and the usage of machine learning methods with these models has had particularly notable success. We present here an approach toward analyzing…

Populations and Evolution · Quantitative Biology 2022-08-19 Haoran Hu , Connor M Kennedy , Panayotis G. Kevrekidis , Hongkun Zhang

Data-driven deep learning provides efficient algorithms for parameter identification of epidemiology models. Unlike the constant parameters, the complexity of identifying time-varying parameters is largely increased. In this paper, a…

Dynamical Systems · Mathematics 2021-03-19 Jie Long , Abdul Khaliq , Khaled Furati

In this study, we considered the problem of estimating epidemiological parameters based on physics-informed neural networks (PINNs). In practice, not all trajectory data corresponding to the population estimated by epidemic models can be…

Machine Learning · Computer Science 2024-07-18 Mizuka Komatsu

Memory has a great impact on the evolution of every process related to human societies. Among them, the evolution of an epidemic is directly related to the individuals' experiences. Indeed, any real epidemic process is clearly sustained by…

Physics and Society · Physics 2017-03-10 M. Saeedian , M. Khalighi , N. Azimi-Tafreshi , G. R. Jafari , M. Ausloos

Physics-Informed Neural Network (PINN) is a deep learning framework that integrates the governing equations underlying data into a loss function. In this study, we consider the problem of estimating state variables and parameters in…

Symbolic Computation · Computer Science 2025-08-07 Mizuka Komatsu

Forecasting temporal processes such as virus spreading in epidemics often requires more than just observed time-series data, especially at the beginning of a wave when data is limited. Traditional methods employ mechanistic models like the…

Artificial Intelligence · Computer Science 2024-11-12 Thang Nguyen , Dung Nguyen , Kha Pham , Truyen Tran

The spread of many infectious diseases is modeled using variants of the SIR compartmental model, which is a coupled differential equation. The coefficients of the SIR model determine the spread trajectories of disease, on whose basis…

Machine Learning · Computer Science 2023-03-28 Ritam Majumdar , Shirish Karande , Lovekesh Vig

Physics-informed neural networks (PINNs) are effective in solving integer-order partial differential equations (PDEs) based on scattered and noisy data. PINNs employ standard feedforward neural networks (NNs) with the PDEs explicitly…

Computational Physics · Physics 2021-11-03 Guofei Pang , Lu Lu , George Em Karniadakis

When investigating epidemic dynamics through differential models, the parameters needed to understand the phenomenon and to simulate forecast scenarios require a delicate calibration phase, often made even more challenging by the scarcity…

Numerical Analysis · Mathematics 2023-09-11 Giulia Bertaglia , Chuan Lu , Lorenzo Pareschi , Xueyu Zhu

The COVID-19 pandemic has highlighted the need for quantitative modeling and analysis to understand real-world disease dynamics. In particular, post hoc analyses using compartmental models offer valuable insights into the effectiveness of…

Machine Learning · Computer Science 2025-10-09 Phillip Rothenbeck , Sai Karthikeya Vemuri , Niklas Penzel , Joachim Denzler

Physics informed neural networks (PINNs) have proven to be an efficient tool to represent problems for which measured data are available and for which the dynamics in the data are expected to follow some physical laws. In this paper, we…

Machine Learning · Computer Science 2023-06-14 Fabian Heldmann , Sarah Berkhahn , Matthias Ehrhardt , Kathrin Klamroth

Accurate epidemic forecasting is critical for informing public health decisions and timely interventions. While Physics-Informed Neural Networks have shown promise in various scientific domains, their potential application to real-time…

Physics and Society · Physics 2026-05-20 Martina Rama , Gabriele Santin , Giulia Cencetti , Michele Tizzoni , Bruno Lepri

Physics-Informed Neural Networks (PINNs) embed the partial differential equations (PDEs) governing the system under study directly into the training of Neural Networks, ensuring solutions that respect physical laws. While effective for…

General Relativity and Quantum Cosmology · Physics 2026-05-13 Matteo Scialpi , Francesco Di Clemente , Leigh Smith , Michał Bejger

Physics-informed neural networks (PINNs) provide a powerful framework for learning governing equations of dynamical systems from data. Biologically-informed neural networks (BINNs) are a variant of PINNs that preserve the known differential…

Machine Learning · Computer Science 2026-04-21 William Lavery , Jodie A. Cochrane , Christian Olesen , Dagim S. Tadele , John T. Nardini , Sara Hamis
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