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Flexible estimation of heterogeneous treatment effects lies at the heart of many statistical challenges, such as personalized medicine and optimal resource allocation. In this paper, we develop a general class of two-step algorithms for…

Machine Learning · Statistics 2020-08-07 Xinkun Nie , Stefan Wager

The adverse drug reactions (ADRs) predicted based on the biased records in FAERS (U.S. Food and Drug Administration Adverse Event Reporting System) may mislead diagnosis online. Generally, such problems are solved by optimizing reporting…

Machine Learning · Computer Science 2025-12-30 Tao Li , Peilin Li , Kui Lu , Yilei Wang , Junliang Shang , Guangshun Li , Huiyu Zhou

We investigate the problem of machine learning-based (ML) predictive inference on individual treatment effects (ITEs). Previous work has focused primarily on developing ML-based meta-learners that can provide point estimates of the…

Machine Learning · Computer Science 2023-08-30 Ahmed Alaa , Zaid Ahmad , Mark van der Laan

Dynamic Facial Expression Recognition (DFER) plays a critical role in affective computing and human-computer interaction. Although existing methods achieve comparable performance, they inevitably suffer from performance degradation under…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Feng-Qi Cui , Anyang Tong , Jinyang Huang , Jie Zhang , Dan Guo , Zhi Liu , Meng Wang

Estimating individualized treatment effects (ITEs) from observational data is crucial for decision-making. In order to obtain unbiased ITE estimates, a common assumption is that all confounders are observed. However, in practice, it is…

Machine Learning · Statistics 2021-12-07 Milan Kuzmanovic , Tobias Hatt , Stefan Feuerriegel

We initiate the study of federated reinforcement learning under environmental heterogeneity by considering a policy evaluation problem. Our setup involves $N$ agents interacting with environments that share the same state and action space…

Machine Learning · Computer Science 2024-07-02 Han Wang , Aritra Mitra , Hamed Hassani , George J. Pappas , James Anderson

A new meta-algorithm for estimating the conditional average treatment effects is proposed in the paper. The main idea underlying the algorithm is to consider a new dataset consisting of feature vectors produced by means of concatenation of…

Machine Learning · Statistics 2019-09-10 Lev V. Utkin , Mikhail V. Kots , Viacheslav S. Chukanov

Inspired by recent advances in diffusion models, which are reminiscent of denoising autoencoders, we investigate whether they can acquire discriminative representations for classification via generative pre-training. This paper shows that…

Computer Vision and Pattern Recognition · Computer Science 2023-08-22 Weilai Xiang , Hongyu Yang , Di Huang , Yunhong Wang

This paper studies the interactive fixed effects (IFE) estimator in a panel-data setting with heterogeneous treatment effects. We show that, if the treatment-effect heterogeneity admits a linear factor structure, the IFE estimator could…

Econometrics · Economics 2026-05-01 Murilo Cardoso , Bruno Ferman , Marcelo Fernandes

Distributional treatment effects can be invisible to means: a treatment may preserve average outcomes while changing tails, modes, dispersion, or rare-event probabilities. Kernel tests can detect discrepancies between interventional outcome…

Machine Learning · Statistics 2026-05-11 Houssam Zenati , Arthur Gretton

In this study, we compared two groups, in which subjects were assigned to either the treatment or the control group. In such trials, if the efficacy of the treatment cannot be demonstrated in a population that meets the eligibility…

Methodology · Statistics 2024-07-26 Shintaro Yuki , Kensuke Tanioka , Hiroshi Yadohisa

Backdoor adjustment is a technique in causal inference for estimating interventional quantities from purely observational data. For example, in medical settings, backdoor adjustment can be used to control for confounding and estimate the…

Artificial Intelligence · Computer Science 2023-10-11 Daniel Israel , Aditya Grover , Guy Van den Broeck

We propose a test for the identification of causal effects in mediation and dynamic treatment models that is based on two sets of observed variables, namely covariates to be controlled for and suspected instruments, building on the test by…

Econometrics · Economics 2024-06-21 Martin Huber , Kevin Kloiber , Lukas Laffers

Quantifying the heterogeneity of treatment effect is important for understanding how a commercial product or medical treatment affects different population subgroups. While much of treatment effect heterogeneity analysis focuses on the…

The paper proposes a causal supervised machine learning algorithm to uncover treatment effect heterogeneity in sharp and fuzzy regression discontinuity (RD) designs. We develop a criterion for building an honest ``regression discontinuity…

Econometrics · Economics 2025-09-01 Ágoston Reguly

Federated learning (FL) triggers intra-client and inter-client class imbalance, with the latter compared to the former leading to biased client updates and thus deteriorating the distributed models. Such a bias is exacerbated during the…

Machine Learning · Computer Science 2024-12-24 Chenguang Xiao , Zheming Zuo , Shuo Wang

As estimation of Heterogeneous Treatment Effect (HTE) is increasingly adopted across a wide range of scientific and industrial applications, the treatment action space can naturally expand, from a binary treatment variable to a structured…

Machine Learning · Computer Science 2025-07-09 Jennifer Y. Zhang , Shuyang Du , Will Y. Zou

One of the major challenges in estimating conditional potential outcomes and conditional average treatment effects (CATE) is the presence of hidden confounders. Since testing for hidden confounders cannot be accomplished only with…

Machine Learning · Computer Science 2025-06-17 Ahmed Aloui , Juncheng Dong , Ali Hasan , Vahid Tarokh

In causal inference, estimating heterogeneous treatment effects (HTE) is critical for identifying how different subgroups respond to interventions, with broad applications in fields such as precision medicine and personalized advertising.…

Machine Learning · Computer Science 2024-07-02 Jiehui Zhou , Linxiao Yang , Xingyu Liu , Xinyue Gu , Liang Sun , Wei Chen

An important task in drug development is to identify patients, which respond better or worse to an experimental treatment. Identifying predictive covariates, which influence the treatment effect and can be used to define subgroups of…

Methodology · Statistics 2018-11-27 Marius Thomas , Björn Bornkamp , Katja Ickstadt