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Understanding classifier decision under novel environments is central to the community, and a common practice is evaluating it on labeled test sets. However, in real-world testing, image annotations are difficult and expensive to obtain,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-11 Weijian Deng , Stephen Gould , Liang Zheng

Evidence suggests that networks trained on large datasets generalize well not solely because of the numerous training examples, but also class diversity which encourages learning of enriched features. This raises the question of whether…

Uncertainty of labels in clinical data resulting from intra-observer variability can have direct impact on the reliability of assessments made by deep neural networks. In this paper, we propose a method for modelling such uncertainty in the…

Proper quantification of predictive uncertainty is essential for the use of machine learning in safety-critical applications. Various uncertainty measures have been proposed for this purpose, typically claiming superiority over other…

Machine Learning · Computer Science 2025-12-16 Paul Hofman , Yusuf Sale , Eyke Hüllermeier

This paper considers the use of Machine Learning (ML) in medicine by focusing on the main problem that this computational approach has been aimed at solving or at least minimizing: uncertainty. To this aim, we point out how uncertainty is…

Machine Learning · Computer Science 2018-05-15 Federico Cabitza , Davide Ciucci , Raffaele Rasoini

Medical researchers have solved the problem of estimating the sensitivity and specificity of binary medical diagnostic tests without gold standard tests for comparison. That problem is the same as estimating confusion matrices for…

Machine Learning · Statistics 2022-12-29 Richard Evans

Medical image segmentation supports clinical workflows by precisely delineating anatomical structures and lesions. However, medical image datasets medical image datasets suffer from acquisition noise and annotation ambiguity, causing…

Artificial Intelligence · Computer Science 2026-04-14 Ruiyang Li , Fang Liu , Licheng Jiao , Xinglin Xie , Jiayao Hao , Shuo Li , Xu Liu , Jingyi Yang , Lingling Li , Puhua Chen , Wenping Ma

As larger and more comprehensive datasets become standard in contemporary machine learning, it becomes increasingly more difficult to obtain reliable, trustworthy label information with which to train sophisticated models. To address this…

Machine Learning · Computer Science 2021-06-08 Glenn Dawson , Robi Polikar

Machine Learning (ML) algorithms are vital for supporting clinical decision-making in biomedical informatics. However, their predictive performance can vary across demographic groups, often due to the underrepresentation of historically…

Machine Learning · Computer Science 2025-03-04 Ioannis Bilionis , Ricardo C. Berrios , Luis Fernandez-Luque , Carlos Castillo

With the rise of increasingly powerful and user-facing NLP systems, there is growing interest in assessing whether they have a good representation of uncertainty by evaluating the quality of their predictive distribution over outcomes. We…

Computation and Language · Computer Science 2024-02-27 Joris Baan , Raquel Fernández , Barbara Plank , Wilker Aziz

The quantification of aleatoric and epistemic uncertainty in terms of conditional entropy and mutual information, respectively, has recently become quite common in machine learning. While the properties of these measures, which are rooted…

Machine Learning · Computer Science 2023-06-27 Lisa Wimmer , Yusuf Sale , Paul Hofman , Bern Bischl , Eyke Hüllermeier

Label noise poses a significant challenge in Earth Observation (EO), often degrading the performance and reliability of supervised Machine Learning (ML) models. Yet, given the critical nature of several EO applications, developing robust…

High-quality data is necessary for modern machine learning. However, the acquisition of such data is difficult due to noisy and ambiguous annotations of humans. The aggregation of such annotations to determine the label of an image leads to…

Computer Vision and Pattern Recognition · Computer Science 2022-11-07 Lars Schmarje , Vasco Grossmann , Claudius Zelenka , Sabine Dippel , Rainer Kiko , Mariusz Oszust , Matti Pastell , Jenny Stracke , Anna Valros , Nina Volkmann , Reinhard Koch

The impact of machine learning models on healthcare will depend on the degree of trust that healthcare professionals place in the predictions made by these models. In this paper, we present a method to provide people with clinical expertise…

Machine Learning · Computer Science 2021-03-05 Aniruddh Raghu , John Guttag , Katherine Young , Eugene Pomerantsev , Adrian V. Dalca , Collin M. Stultz

Medical image segmentation modeling is a high-stakes task where understanding of uncertainty is crucial for addressing visual ambiguity. Prior work has developed segmentation models utilizing probabilistic or generative mechanisms to infer…

Computer Vision and Pattern Recognition · Computer Science 2025-06-13 Andre Ye , Quan Ze Chen , Amy Zhang

Modern machine learning methods including deep learning have achieved great success in predictive accuracy for supervised learning tasks, but may still fall short in giving useful estimates of their predictive {\em uncertainty}. Quantifying…

One of the ways to make artificial intelligence more natural is to give it some room for doubt. Two main questions should be resolved in that way. First, how to train a model to estimate uncertainties of its own predictions? And then, what…

Computer Vision and Pattern Recognition · Computer Science 2024-04-17 Alexey Kornaev , Elena Kornaeva , Oleg Ivanov , Ilya Pershin , Danis Alukaev

Large annotated datasets have been a key component in the success of deep learning. However, annotating medical images is challenging as it requires expertise and a large budget. In particular, annotating different types of cells in…

Computer Vision and Pattern Recognition · Computer Science 2022-10-12 Cholmin Kang , Chunggi Lee , Heon Song , Minuk Ma , S ergio Pereira

Understanding data and reaching valid conclusions are of paramount importance in the present era of big data. Machine learning and probability theory methods have widespread application for this purpose in different fields. One critically…

Supervised classification algorithms are used to solve a growing number of real-life problems around the globe. Their performance is strictly connected with the quality of labels used in training. Unfortunately, acquiring good-quality…

Machine Learning · Computer Science 2024-07-08 Daniel Kałuża , Andrzej Janusz , Dominik Ślęzak
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