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The recent boom of large language models (LLMs) has re-ignited the hope that artificial intelligence (AI) systems could aid medical diagnosis. Yet despite dazzling benchmark scores, LLM assistants have yet to deliver measurable improvements…

Artificial Intelligence · Computer Science 2025-07-03 Matthew JY Kang , Wenli Yang , Monica R Roberts , Byeong Ho Kang , Charles B Malpas

This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

Large Language Models (LLMs) excel in handling general knowledge tasks, yet they struggle with user-specific personalization, such as understanding individual emotions, writing styles, and preferences. Personalized Large Language Models…

Artificial Intelligence · Computer Science 2025-09-23 Jiahong Liu , Zexuan Qiu , Zhongyang Li , Quanyu Dai , Wenhao Yu , Jieming Zhu , Minda Hu , Menglin Yang , Tat-Seng Chua , Irwin King

Large language models (LLMs) have demonstrated exceptional performance not only in natural language processing tasks but also in a great variety of non-linguistic domains. In diverse optimization scenarios, there is also a rising trend of…

Neural and Evolutionary Computing · Computer Science 2024-07-09 Beichen Huang , Xingyu Wu , Yu Zhou , Jibin Wu , Liang Feng , Ran Cheng , Kay Chen Tan

The integration of Large Language Models (LLMs) into medical applications has sparked widespread interest across the healthcare industry, from drug discovery and development to clinical decision support, assisting telemedicine, medical…

Computation and Language · Computer Science 2024-12-03 Zifeng Wang , Hanyin Wang , Benjamin Danek , Ying Li , Christina Mack , Hoifung Poon , Yajuan Wang , Pranav Rajpurkar , Jimeng Sun

The widespread application of pre-trained language models (PLMs) in natural language processing (NLP) has led to increasing concerns about their explainability. Selective rationalization is a self-explanatory framework that selects…

Computation and Language · Computer Science 2025-01-07 Libing Yuan , Shuaibo Hu , Kui Yu , Le Wu

In the face of rapidly expanding online medical literature, automated systems for aggregating and summarizing information are becoming increasingly crucial for healthcare professionals and patients. Large Language Models (LLMs), with their…

Computation and Language · Computer Science 2024-03-07 Niraj Yagnik , Jay Jhaveri , Vivek Sharma , Gabriel Pila

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu

Clinical diagnosis prediction models, when provided with a patient's medical history, aim to detect potential diseases early, facilitating timely intervention and improving prognostic outcomes. However, the inherent scarcity of patient data…

Computation and Language · Computer Science 2025-01-30 Mingyu Derek Ma , Xiaoxuan Wang , Yijia Xiao , Anthony Cuturrufo , Vijay S Nori , Eran Halperin , Wei Wang

Large Language Models (LLMs) are transforming artificial intelligence, enabling autonomous agents to perform diverse tasks across various domains. These agents, proficient in human-like text comprehension and generation, have the potential…

Artificial Intelligence · Computer Science 2024-04-10 Saikat Barua

Modeling a system's temporal behaviour in reaction to external stimuli is a fundamental problem in many areas. Pure Machine Learning (ML) approaches often fail in the small sample regime and cannot provide actionable insights beyond…

Machine Learning · Computer Science 2021-06-18 Zhaozhi Qian , William R. Zame , Lucas M. Fleuren , Paul Elbers , Mihaela van der Schaar

While pioneering deep learning methods have made great strides in analyzing electronic health record (EHR) data, they often struggle to fully capture the semantics of diverse medical codes from limited data. The integration of external…

Machine Learning · Computer Science 2024-08-26 Zhihao Yu , Yujie Jin , Yongxin Xu , Xu Chu , Yasha Wang , Junfeng Zhao

Based on official estimates, 50 million people worldwide are affected by dementia, and this number increases by 10 million new patients every year. Without a cure, clinical prognostication and early intervention represent the most effective…

Computation and Language · Computer Science 2024-09-06 Francisco de Arriba-Pérez , Silvia García-Méndez

Optimizing an experimental system can be extremely challenging when each experiment is expensive, time-consuming, or difficult to perform. Existing optimizers for expensive black-box problems, such as Bayesian optimization, are typically…

Accurate prediction of treatment outcomes in lung cancer remains challenging due to the sparsity, heterogeneity, and contextual overload of real-world electronic health data. Traditional models often fail to capture semantic information…

While deep learning techniques have shown promising results in many natural language processing (NLP) tasks, it has not been widely applied to the clinical domain. The lack of large datasets and the pervasive use of domain-specific language…

Computation and Language · Computer Science 2019-06-20 Jiin Nam , Seunghyun Yoon , Kyomin Jung

Masked language modeling (MLM) plays a key role in pretraining large language models. But the MLM objective is often dominated by high-frequency words that are sub-optimal for learning factual knowledge. In this work, we propose an approach…

Computation and Language · Computer Science 2023-04-05 Nafis Sadeq , Byungkyu Kang , Prarit Lamba , Julian McAuley

Undeniably, Large Language Models (LLMs) have stirred an extraordinary wave of innovation in the machine learning research domain, resulting in substantial impact across diverse fields such as reinforcement learning, robotics, and computer…

Machine Learning · Computer Science 2024-05-10 Xingyou Song , Yingtao Tian , Robert Tjarko Lange , Chansoo Lee , Yujin Tang , Yutian Chen

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to…

Computation and Language · Computer Science 2023-11-06 Mingze Yuan , Peng Bao , Jiajia Yuan , Yunhao Shen , Zifan Chen , Yi Xie , Jie Zhao , Yang Chen , Li Zhang , Lin Shen , Bin Dong

Digital health tools have the potential to significantly improve the delivery of healthcare services. However, their adoption remains comparatively limited due, in part, to challenges surrounding usability and trust. Large Language Models…

Computation and Language · Computer Science 2024-03-01 Fergus Imrie , Paulius Rauba , Mihaela van der Schaar