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The concept of personalised medicine in cancer therapy is becoming increasingly important. There already exist drugs administered specifically for patients with tumours presenting well-defined mutations. However, the field is still in its…

Biomolecules · Quantitative Biology 2024-08-26 Abbi Abdel-Rehim , Oghenejokpeme Orhobor , Gareth Griffiths , Larisa Soldatova , Ross D. King

With the advancement of Large Language Model (LLM) for natural language processing, this paper presents an intriguing finding: a frozen pre-trained LLM layer can process visual tokens for medical image segmentation tasks. Specifically, we…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Fenghe Tang , Wenxin Ma , Zhiyang He , Xiaodong Tao , Zihang Jiang , S. Kevin Zhou

The recent success of Large Language Models (LLMs) has had a significant impact on the healthcare field, providing patients with medical advice, diagnostic information, and more. However, due to a lack of professional medical knowledge,…

Computation and Language · Computer Science 2024-06-27 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Xiang Wan , Feng Jiang , Benyou Wang

The significant progress of large language models (LLMs) provides a promising opportunity to build human-like systems for various practical applications. However, when applied to specific task domains, an LLM pre-trained on a…

Information Retrieval · Computer Science 2023-11-21 Jing Yao , Wei Xu , Jianxun Lian , Xiting Wang , Xiaoyuan Yi , Xing Xie

Research on language technology for the development of medical applications is currently a hot topic in Natural Language Understanding and Generation. Thus, a number of large language models (LLMs) have recently been adapted to the medical…

Recent large language models (LLMs) have demonstrated remarkable performance on a variety of natural language processing (NLP) tasks, leading to intense excitement about their applicability across various domains. Unfortunately, recent work…

Computation and Language · Computer Science 2023-02-13 Yaqi Xie , Chen Yu , Tongyao Zhu , Jinbin Bai , Ze Gong , Harold Soh

Despite their strong linguistic capabilities, Large Language Models (LLMs) are computationally demanding and require substantial resources for fine-tuning, which is unadapted to privacy and budget constraints of many healthcare settings. To…

Computation and Language · Computer Science 2026-04-30 Pierre Epron , Adrien Coulet , Mehwish Alam

Speech tokenization serves as the foundation of speech language model (LM), enabling them to perform various tasks such as spoken language modeling, text-to-speech, speech-to-text, etc. Most speech tokenizers are trained independently of…

Computation and Language · Computer Science 2024-09-11 Arnon Turetzky , Yossi Adi

Optimization algorithms and large language models (LLMs) enhance decision-making in dynamic environments by integrating artificial intelligence with traditional techniques. LLMs, with extensive domain knowledge, facilitate intelligent…

Neural and Evolutionary Computing · Computer Science 2024-05-17 Sen Huang , Kaixiang Yang , Sheng Qi , Rui Wang

Pre-trained language models (PLM) have advanced the state-of-the-art across NLP applications, but lack domain-specific knowledge that does not naturally occur in pre-training data. Previous studies augmented PLMs with symbolic knowledge for…

Computation and Language · Computer Science 2022-12-19 Denis Emelin , Daniele Bonadiman , Sawsan Alqahtani , Yi Zhang , Saab Mansour

Large Language Models (LLMs) have demonstrated remarkable capabilities across various domains and are moving towards more specialized areas. Recent advanced proprietary models such as GPT-4 and Gemini have achieved significant advancements…

Computation and Language · Computer Science 2024-10-30 Kaiyan Zhang , Sihang Zeng , Ermo Hua , Ning Ding , Zhang-Ren Chen , Zhiyuan Ma , Haoxin Li , Ganqu Cui , Biqing Qi , Xuekai Zhu , Xingtai Lv , Hu Jinfang , Zhiyuan Liu , Bowen Zhou

Recent advances in natural language processing (NLP) have opened up greater opportunities to enable fine-tuned large language models (LLMs) to behave as more powerful interactive agents through improved instruction-following ability.…

Machine Learning · Computer Science 2025-10-27 Jerry Huang , Peng Lu , Qiuhao Zeng

Large Language Models (LLMs) hold great promise to revolutionize current clinical systems for their superior capacities on medical text processing tasks and medical licensing exams. Meanwhile, traditional ML models such as SVM and XGBoost…

Computation and Language · Computer Science 2024-11-12 Canyu Chen , Jian Yu , Shan Chen , Che Liu , Zhongwei Wan , Danielle Bitterman , Fei Wang , Kai Shu

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Large Language Models (LLMs) have quickly become an invaluable assistant for a variety of tasks. However, their effectiveness is constrained by their ability to tailor responses to human preferences and behaviors via personalization. Prior…

Computation and Language · Computer Science 2024-11-21 Lucie Charlotte Magister , Katherine Metcalf , Yizhe Zhang , Maartje ter Hoeve

Pre-trained large-scale language models (LLMs) excel at producing coherent articles, yet their outputs may be untruthful, toxic, or fail to align with user expectations. Current approaches focus on using reinforcement learning with human…

Computation and Language · Computer Science 2024-06-06 Dehong Xu , Liang Qiu , Minseok Kim , Faisal Ladhak , Jaeyoung Do

Large Language Models (LLMs) have significant impact on the healthcare scenarios but remain prohibitively large for deployment in real-time, resource-constrained environments such as edge devices. In this work, we introduce a novel medical…

Computation and Language · Computer Science 2025-08-08 Uttej Kallakurik , Edward Humes , Rithvik Jonna , Xiaomin Lin , Tinoosh Mohsenin

Large Language Models (LLMs) have revolutionized various sectors, including healthcare where they are employed in diverse applications. Their utility is particularly significant in the context of rare diseases, where data scarcity,…

Computation and Language · Computer Science 2024-08-20 Qiuhao Lu , Rui Li , Andrew Wen , Jinlian Wang , Liwei Wang , Hongfang Liu

Pre-trained Large Language Models (LLMs) often struggle on out-of-domain datasets like healthcare focused text. We explore specialized pre-training to adapt smaller LLMs to different healthcare datasets. Three methods are assessed:…

Computation and Language · Computer Science 2024-04-01 Niall Taylor , Dan Schofield , Andrey Kormilitzin , Dan W Joyce , Alejo Nevado-Holgado

Effective patient-provider communication is crucial in clinical care, directly impacting patient outcomes and quality of life. Traditional evaluation methods, such as human ratings, patient feedback, and provider self-assessments, are often…

Computation and Language · Computer Science 2024-09-25 Zhiyuan Wang , Fangxu Yuan , Virginia LeBaron , Tabor Flickinger , Laura E. Barnes
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