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Cluster analysis methods are used to identify homogeneous subgroups in a data set. In biomedical applications, one frequently applies cluster analysis in order to identify biologically interesting subgroups. In particular, one may wish to…

Methodology · Statistics 2016-09-23 Sheila Gaynor , Eric Bair

Identifying and counting blood components such as red blood cells, various types of white blood cells, and platelets is a critical task for healthcare practitioners. Deep learning approaches, particularly convolutional neural networks…

Image and Video Processing · Electrical Eng. & Systems 2025-05-06 H. Martin Gillis , Yogeshwar Shendye , Paul Hollensen , Alan Fine , Thomas Trappenberg

An important step in diagnostics is the isolation of specific cells and microorganisms of interest from blood. Since such bioparticles are often present at very low concentrations, throughput needs to be as high as possible. In addition, to…

Soft Condensed Matter · Physics 2019-07-31 Stefan H. Holm , Zunmin Zhang , Jason P. Beech , Gerhard Gompper , Dmitry A. Fedosov , Jonas O. Tegenfeldt

In this paper, a methodology for the automated detection and classification of Tuberculosis(TB) is presented. Tuberculosis is a disease caused by mycobacterium which spreads through the air and attacks low immune bodies easily. Our…

Artificial Intelligence · Computer Science 2011-08-05 Asha. T , S. Natarajan , K. N. B. Murthy

Acute and chronic wounds are a challenge to healthcare systems around the world and affect many people's lives annually. Wound classification is a key step in wound diagnosis that would help clinicians to identify an optimal treatment…

Computer Vision and Pattern Recognition · Computer Science 2021-06-07 Behrouz Rostami , D. M. Anisuzzaman , Chuanbo Wang , Sandeep Gopalakrishnan , Jeffrey Niezgoda , Zeyun Yu

Circulating tumor cells (CTCs) are crucial biomarkers in liquid biopsy, offering a noninvasive tool for cancer patient management. However, their identification remains particularly challenging due to their limited number and heterogeneity.…

Image and Video Processing · Electrical Eng. & Systems 2025-11-24 Martina Russo , Giulia Bertolini , Vera Cappelletti , Cinzia De Marco , Serena Di Cosimo , Petra Paiè , Nadia Brancati

Accurate morphological classification of white blood cells (WBCs) is an important step in the diagnosis of leukemia, a disease in which nonfunctional blast cells accumulate in the bone marrow. Recently, deep convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Rao Muhammad Umer , Armin Gruber , Sayedali Shetab Boushehri , Christian Metak , Carsten Marr

Label-free single-cell imaging offers a scalable, non-invasive alternative to fluorescence-based cytometry, yet inferring molecular phenotypes directly from bright-field morphology remains challenging. We present a unified Deep Learning…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Saqib Nazir , Ardhendu Behera

Clustering algorithms are one of the main analytical methods to detect patterns in unlabeled data. Existing clustering methods typically treat samples in a dataset as points in a metric space and compute distances to group together similar…

Machine Learning · Computer Science 2021-10-12 Tarek Naous , Srinjay Sarkar , Abubakar Abid , James Zou

Clustering is one of the most widely used procedures in the analysis of microarray data, for example with the goal of discovering cancer subtypes based on observed heterogeneity of genetic marks between different tissues. It is well-known…

Methodology · Statistics 2009-04-21 Heng Lian

Detection of blood cells in microscopic images has become a major focus of medical image analysis, playing a crucial role in gaining valuable insights into a patient's health. Manual blood cell checks for disease detection are known to be…

Computer Vision and Pattern Recognition · Computer Science 2025-07-28 Ahmed Endris Hasen , Yang Shangming , Chiagoziem C. Ukwuoma , Biniyam Gashaw , Abel Zenebe Yutra

We present a method for automatic cell classification in tissue samples using an automated training set from multiplexed immunofluorescence images. The method utilizes multiple markers stained in situ on a single tissue section on a robust…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Alberto Santamaria-Pang , Anup Sood , Dan Meyer , Aritra Chowdhury , Fiona Ginty

In this paper we discuss a new method for detecting leukemia in microscopic blood smear images using deep neural networks to diagnose leukemia early in blood. leukemia is considered one of the most dangerous mortality causes for a human…

Image and Video Processing · Electrical Eng. & Systems 2023-01-10 Abdelmageed Ahmed , Alaa Nagy , Ahmed Kamal , Daila Farghl

Deep learning methods in the literature are commonly benchmarked on image data sets, which may not be suitable or effective baselines for non-image tabular data. In this paper, we take a data-centric view to perform one of the first studies…

Machine Learning · Computer Science 2023-01-12 Sakib Abrar , Ali Sekmen , Manar D. Samad

Accurate detection and segmentation of gastrointestinal bleeding are critical for diagnosing diseases such as peptic ulcers and colorectal cancer. This study proposes a two-stage framework that decouples classification and grounding to…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Yu-Fan Lin , Bo-Cheng Qiu , Chia-Ming Lee , Chih-Chung Hsu

Spectral Clustering is a popular technique to split data points into groups, especially for complex datasets. The algorithms in the Spectral Clustering family typically consist of multiple separate stages (such as similarity matrix…

Machine Learning · Computer Science 2019-11-04 Yifei Wang , Rui Liu , Yong Chen , Hui Zhangs , Zhiwen Ye

White blood cell (WBC) classification plays a vital role in hematology for diagnosing various medical conditions. However, it faces significant challenges due to domain shifts caused by variations in sample sources (e.g., blood or bone…

The manual evaluation, classification and counting of biological objects demands for an enormous expenditure of time and subjective human input may be a source of error. Investigating the shape of red blood cells (RBCs) in microcapillary…

Biological Physics · Physics 2018-06-22 Alexander Kihm , Lars Kaestner , Christian Wagner , Stephan Quint

Early screening for cancer has proven to improve the survival rate and spare patients from intensive and costly treatments due to late diagnosis. Cancer screening in the healthy population involves an initial risk stratification step to…