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Genome-Wide Association Studies are typically conducted using linear models to find genetic variants associated with common diseases. In these studies, association testing is done on a variant-by-variant basis, possibly missing out on…

In artificial neural networks trained with gradient descent, the weights used for processing stimuli are also used during backward passes to calculate gradients. For the real brain to approximate gradients, gradient information would have…

Neurons and Cognition · Quantitative Biology 2020-02-04 Jordan Guerguiev , Konrad P. Kording , Blake A. Richards

We present a new approach to automatic amortized inference in universal probabilistic programs which improves performance compared to current methods. Our approach is a variation of inference compilation (IC) which leverages deep neural…

Machine Learning · Computer Science 2019-10-29 William Harvey , Andreas Munk , Atılım Güneş Baydin , Alexander Bergholm , Frank Wood

Alzheimer's disease and Frontotemporal dementia are two major types of dementia. Their accurate diagnosis and differentiation is crucial for determining specific intervention and treatment. However, differential diagnosis of these two types…

Image and Video Processing · Electrical Eng. & Systems 2022-06-16 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

Physics-informed deep learning has emerged as a promising alternative for solving partial differential equations. However, for complex problems, training these networks can still be challenging, often resulting in unsatisfactory accuracy…

Machine Learning · Computer Science 2025-09-18 Wenqian Chen , Amanda A. Howard , Panos Stinis

One of the hallmark symptoms of Parkinson's Disease (PD) is the progressive loss of postural reflexes, which eventually leads to gait difficulties and balance problems. Identifying disruptions in brain function associated with gait…

Machine Learning · Computer Science 2023-07-26 Favour Nerrise , Qingyu Zhao , Kathleen L. Poston , Kilian M. Pohl , Ehsan Adeli

Physics-informed neural networks (PINNs) offer a powerful approach to solving partial differential equations (PDEs), which are ubiquitous in the quantitative sciences. Applied to both forward and inverse problems across various scientific…

The identification of Alzheimer's disease (AD) and its early stages using structural magnetic resonance imaging (MRI) has been attracting the attention of researchers. Various data-driven approaches have been introduced to capture subtle…

Artificial Intelligence · Computer Science 2021-08-11 Changhyun Park , Heung-Il Suk

Retrieval-Augmented Generation (RAG), by incorporating external knowledge with parametric memory of language models, has become the state-of-the-art architecture for open-domain QA tasks. However, common knowledge bases are inherently…

Computation and Language · Computer Science 2023-12-01 Zhebin Zhang , Xinyu Zhang , Yuanhang Ren , Saijiang Shi , Meng Han , Yongkang Wu , Ruofei Lai , Zhao Cao

Physics-informed neural network (PINN) is a powerful emerging method for studying forward-inverse problems of partial differential equations (PDEs), even from limited sample data. Variable coefficient PDEs, which model real-world phenomena,…

Computational Physics · Physics 2025-03-07 Hui-Juan Zhou , Yong Chen

Advancements in deep learning have enabled highly accurate arrhythmia detection from electrocardiogram (ECG) signals, but limited interpretability remains a barrier to clinical adoption. This study investigates the application of…

Machine Learning · Computer Science 2025-08-26 Joschka Beck , Arlene John

The paper presents a deep learning-aided iterative detection algorithm for massive overloaded MIMO systems. Since the proposed algorithm is based on the projected gradient descent method with trainable parameters, it is named as trainable…

Information Theory · Computer Science 2018-12-27 Satoshi Takabe , Masayuki Imanishi , Tadashi Wadayama , Kazunori Hayashi

Local explanation methods, also known as attribution methods, attribute a deep network's prediction to its input (cf. Baehrens et al. (2010)). We respond to the claim from Adebayo et al. (2018) that local explanation methods lack…

Machine Learning · Computer Science 2018-06-13 Mukund Sundararajan , Ankur Taly

Generalized additive models (GAMs) are favored in many regression and binary classification problems because they are able to fit complex, nonlinear functions while still remaining interpretable. In the first part of this paper, we…

Machine Learning · Computer Science 2019-06-03 Xuezhou Zhang , Sarah Tan , Paul Koch , Yin Lou , Urszula Chajewska , Rich Caruana

Research in Explainable Artificial Intelligence (XAI) is increasing, aiming to make deep learning models more transparent. Most XAI methods focus on justifying the decisions made by Artificial Intelligence (AI) systems in security-relevant…

Deep learning-based medical image analysis faces a significant barrier due to the lack of interpretability. Conventional explainable AI (XAI) techniques, such as Grad-CAM and SHAP, often highlight regions outside clinical interests. To…

Image and Video Processing · Electrical Eng. & Systems 2025-02-17 Yuhao Zhang , Mingcheng Zhu , Zhiyao Luo

A conventional Bayesian approach to prediction uses the posterior distribution to integrate out parameters in a density for unobserved data conditional on the observed data and parameters. When the true posterior is intractable, it is…

Methodology · Statistics 2026-02-27 Lucas Kock , Scott A. Sisson , G. S. Rodrigues , David J. Nott

Interpretation and improvement of deep neural networks relies on better understanding of their underlying mechanisms. In particular, gradients of classes or concepts with respect to the input features (e.g., pixels in images) are often used…

Computer Vision and Pattern Recognition · Computer Science 2020-12-02 Lennart Brocki , Neo Christopher Chung

Deep learning based automated pathological diagnosis has markedly improved diagnostic efficiency and reduced variability between observers, yet its clinical adoption remains limited by opaque model decisions and a lack of traceable…

Alzheimer's Disease is the most common cause of dementia. Accurate diagnosis and prognosis of this disease are essential to design an appropriate treatment plan, increasing the life expectancy of the patient. Intense research has been…

Image and Video Processing · Electrical Eng. & Systems 2023-01-05 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé