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We propose a new method, Patch-CNN, for diffusion tensor (DT) estimation from only six-direction diffusion weighted images (DWI). Deep learning-based methods have been recently proposed for dMRI parameter estimation, using either voxel-wise…

Computer Vision and Pattern Recognition · Computer Science 2023-07-06 Tobias Goodwin-Allcock , Ting Gong , Robert Gray , Parashkev Nachev , Hui Zhang

Models of diffusion MRI within a voxel are useful for making inferences about the properties of the tissue and inferring fiber orientation distribution used by tractography algorithms. A useful model must fit the data accurately. However,…

Quantitative Methods · Quantitative Biology 2017-02-08 Ariel Rokem , Jason D. Yeatman , Franco Pestilli , Kendrick N. Kay , Aviv Mezer , Stefan van der Walt , Brian A. Wandell

White matter tract segmentation is crucial for studying brain structural connectivity and neurosurgical planning. However, segmentation remains challenging due to issues like class imbalance between major and minor tracts, structural…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Anoushkrit Goel , Bipanjit Singh , Ankita Joshi , Ranjeet Ranjan Jha , Chirag Ahuja , Aditya Nigam , Arnav Bhavsar

Tractography has become an indispensable part of brain connectivity studies. However, it is currently facing problems with reliability. In particular, a substantial amount of nerve fiber reconstructions (streamlines) in tractograms produced…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Antonia Hain , Daniel Jörgens , Rodrigo Moreno

Diffusion magnetic resonance imaging (dMRI) data allow to reconstruct the 3D pathways of axons within the white matter of the brain as a tractography. The analysis of tractographies has drawn attention from the machine learning and pattern…

Machine Learning · Statistics 2015-04-03 Emanuele Olivetti , Thien Bao Nguyen , Paolo Avesani

White matter bundle segmentation is a cornerstone of modern tractography to study the brain's structural connectivity in domains such as neurological disorders, neurosurgery, and aging. In this study, we present FIESTA (FIbEr Segmentation…

White matter (WM) tract segmentation is a crucial step for brain connectivity studies. It is performed on diffusion magnetic resonance imaging (dMRI), and deep neural networks (DNNs) have achieved promising segmentation accuracy. Existing…

Image and Video Processing · Electrical Eng. & Systems 2023-09-26 Wan Liu , Chuyang Ye

Tractography parcellation classifies streamlines reconstructed from diffusion MRI into anatomically defined fiber tracts for clinical and research applications. However, clinical scans often have incomplete fields of view (FOV) where brain…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Yuqian Chen , Leo Zekelman , Yui Lo , Suheyla Cetin-Karayumak , Tengfei Xue , Yogesh Rathi , Nikos Makris , Fan Zhang , Weidong Cai , Lauren J. O'Donnell

This work presents BundleSeg, a reliable, reproducible, and fast method for extracting white matter pathways. The proposed method combines an iterative registration procedure with a recently developed precise streamline search algorithm…

Image and Video Processing · Electrical Eng. & Systems 2023-08-23 Etienne St-Onge , Kurt G Schilling , Francois Rheault

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial strategy for white matter (WM) parcellation. Current methods primarily use the geometric information of fibers (i.e., the spatial trajectories) to group similar fibers…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Jin Wang , Bocheng Guo , Yijie Li , Junyi Wang , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

Diffusion Magnetic Resonance Imaging (MRI) exploits the anisotropic diffusion of water molecules in the brain to enable the estimation of the brain's anatomical fiber tracts at a relatively high resolution. In particular, tractographic…

Computational Engineering, Finance, and Science · Computer Science 2016-09-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

Recent progress in diffusion MRI and tractography algorithms as well as the launch of the Human Connectome Project (HCP) have provided brain research with an abundance of structural connectivity data. In this work, we describe and evaluate…

Neurons and Cognition · Quantitative Biology 2016-06-02 Kamal Shadi , Saideh Bakhshi , David A. Gutman , Helen S. Mayberg , Constantine Dovrolis

One of the main issues of the current tractography methods is their high false-positive rate. Tractogram filtering is an option to remove false-positive streamlines from tractography data in a post-processing step. In this paper, we train a…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Daniel Jörgens , Pierre-Marc Jodoin , Maxime Descoteaux , Rodrigo Moreno

Diffusion MRI tractography enables in vivo reconstruction of white matter (WM) pathways. Two key tasks in tractography analysis include: 1) tractogram registration that aligns streamlines across individuals, and 2) streamline clustering…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Yijie Li , Xi Zhu , Junyi Wang , Ye Wu , Lauren J. O'Donnell , Fan Zhang

We propose a geometric deep-learning-based framework, TractGeoNet, for performing regression using diffusion magnetic resonance imaging (dMRI) tractography and associated pointwise tissue microstructure measurements. By employing a point…

Computer Vision and Pattern Recognition · Computer Science 2023-07-11 Yuqian Chen , Leo R. Zekelman , Chaoyi Zhang , Tengfei Xue , Yang Song , Nikos Makris , Yogesh Rathi , Alexandra J. Golby , Weidong Cai , Fan Zhang , Lauren J. O'Donnell

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial method for white matter (WM) parcellation to enable analysis of brains structural connectivity in health and disease. Current fiber clustering strategies primarily use…

Image and Video Processing · Electrical Eng. & Systems 2025-11-04 Bocheng Guo , Jin Wang , Yijie Li , Junyi Wang , Mingyu Gao , Puming Feng , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

While the major white matter tracts are of great interest to numerous studies in neuroscience and medicine, their manual dissection in larger cohorts from diffusion MRI tractograms is time-consuming, requires expert knowledge and is hard to…

Computer Vision and Pattern Recognition · Computer Science 2018-06-15 Jakob Wasserthal , Peter F. Neher , Klaus H. Maier-Hein

The widespread use of GPS devices has driven advances in spatiotemporal data mining, enabling machine learning models to simulate human decision making and generate realistic trajectories, addressing both data collection costs and privacy…

Machine Learning · Computer Science 2025-10-09 Zhiyang Zhang , Ningcong Chen , Xin Zhang , Yanhua Li , Shen Su , Hui Lu , Jun Luo

Brain nuclei are clusters of anatomically distinct neurons that serve as important hubs for processing and relaying information in various neural circuits. Fine-scale parcellation of the brain nuclei is vital for a comprehensive…

Image and Video Processing · Electrical Eng. & Systems 2025-09-03 Haolin He , Ce Zhu , Le Zhang , Yipeng Liu , Xiao Xu , Yuqian Chen , Leo Zekelman , Jarrett Rushmore , Yogesh Rathi , Nikos Makris , Lauren J. O'Donnell , Fan Zhang

Neuroimaging measures of the brain's white matter connections can enable the prediction of non-imaging phenotypes, such as demographic and cognitive measures. Existing works have investigated traditional microstructure and connectivity…

Computer Vision and Pattern Recognition · Computer Science 2023-05-23 Wan Liu , Yuqian Chen , Chuyang Ye , Nikos Makris , Yogesh Rathi , Weidong Cai , Fan Zhang , Lauren J. O'Donnell