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In computational pathology, understanding and generation have evolved along disparate paths: advanced understanding models already exhibit diagnostic-level competence, whereas generative models largely simulate pixels. Progress remains…

Computer Vision and Pattern Recognition · Computer Science 2026-02-27 Minghao Han , Yichen Liu , Yizhou Liu , Zizhi Chen , Jingqun Tang , Xuecheng Wu , Dingkang Yang , Lihua Zhang

We present Consistent Assignment of Views over Random Partitions (CARP), a self-supervised clustering method for representation learning of visual features. CARP learns prototypes in an end-to-end online fashion using gradient descent…

Computer Vision and Pattern Recognition · Computer Science 2023-10-30 Thalles Silva , Adín Ramírez Rivera

Vision Foundation Models (VFMs) and Vision Language Models (VLMs) have revolutionized computer vision by providing rich semantic and geometric representations. This paper presents a comprehensive visual comparison between CLIP based and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-10 Md Selim Sarowar , Sungho Kim

Contrastive vision-language models such as CLIP have demonstrated strong performance across a wide range of multimodal tasks by learning from aligned image-text pairs. However, their ability to handle complex, real-world web documents…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Yiqi Lin , Alex Jinpeng Wang , Linjie Li , Zhengyuan Yang , Mike Zheng Shou

Small-molecule foundation models are typically pretrained on standalone molecular data, unlike vision and language models that often benefit from cross-modal or relational supervision. Protein-ligand co-folding provides a molecular analogue…

Biomolecules · Quantitative Biology 2026-05-25 Hyosoon Jang , Hyunjin Seo , Honghui Kim , Seonghyun Park , Taewon Kim , Yunhui Jang , Sungsoo Ahn

Accurate image classification and retrieval are of importance for clinical diagnosis and treatment decision-making. The recent contrastive language-image pretraining (CLIP) model has shown remarkable proficiency in understanding natural…

Computer Vision and Pattern Recognition · Computer Science 2024-06-13 Sunyi Zheng , Xiaonan Cui , Yuxuan Sun , Jingxiong Li , Honglin Li , Yunlong Zhang , Pingyi Chen , Xueping Jing , Zhaoxiang Ye , Lin Yang

Whole-slide image analysis via the means of computational pathology often relies on processing tessellated gigapixel images with only slide-level labels available. Applying multiple instance learning-based methods or transformer models is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-20 Joshua Butke , Noriaki Hashimoto , Ichiro Takeuchi , Hiroaki Miyoshi , Koichi Ohshima , Jun Sakuma

Comparing different neural network representations and determining how representations evolve over time remain challenging open questions in our understanding of the function of neural networks. Comparing representations in neural networks…

Machine Learning · Statistics 2018-10-25 Ari S. Morcos , Maithra Raghu , Samy Bengio

The rapid adoption of transformer-based models in computational pathology has enabled prediction of molecular and clinical biomarkers from H&E whole-slide images, yet interpretability has not kept pace with model complexity. While…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Marco Gustav , Fabian Wolf , Christina Glasner , Nic G. Reitsam , Stefan Schulz , Kira Aschenbroich , Bruno Märkl , Sebastian Foersch , Jakob Nikolas Kather

Foundation models are becoming increasingly popular due to their strong generalization capabilities resulting from being trained on huge datasets. These generalization capabilities are attractive in areas such as NIR Iris Presentation…

Computer Vision and Pattern Recognition · Computer Science 2025-01-14 Juan E. Tapia , Lázaro Janier González-Soler , Christoph Busch

Contrastive Language-Image Pretraining (CLIP) stands out as a prominent method for image representation learning. Various architectures, from vision transformers (ViTs) to convolutional networks (ResNets) have been trained with CLIP to…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Cristian Rodriguez-Opazo , Ehsan Abbasnejad , Damien Teney , Hamed Damirchi , Edison Marrese-Taylor , Anton van den Hengel

Pre-trained representations are becoming crucial for many NLP and perception tasks. While representation learning in NLP has transitioned to training on raw text without human annotations, visual and vision-language representations still…

Computer Vision and Pattern Recognition · Computer Science 2021-06-14 Chao Jia , Yinfei Yang , Ye Xia , Yi-Ting Chen , Zarana Parekh , Hieu Pham , Quoc V. Le , Yunhsuan Sung , Zhen Li , Tom Duerig

The appearance of histopathology images depends on tissue type, staining and digitization procedure. These vary from source to source and are the potential causes for domain-shift problems. Owing to this problem, despite the great success…

Computer Vision and Pattern Recognition · Computer Science 2022-08-24 Trinh Thi Le Vuong , Quoc Dang Vu , Mostafa Jahanifar , Simon Graham , Jin Tae Kwak , Nasir Rajpoot

Vision transformers (ViTs) encoding an image as a sequence of patches bring new paradigms for semantic segmentation.We present an efficient framework of representation separation in local-patch level and global-region level for semantic…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Yuanduo Hong , Huihui Pan , Weichao Sun , Xinghu Yu , Huijun Gao

Pathological image segmentation faces numerous challenges, particularly due to ambiguous semantic boundaries and the high cost of pixel-level annotations. Although recent semi-supervised methods based on consistency regularization (e.g.,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Mingxi Fu , Fanglei Fu , Xitong Ling , Huaitian Yuan , Tian Guan , Yonghong He , Lianghui Zhu

Foundation models trained with self-supervised learning (SSL) on large-scale histological images have significantly accelerated the development of computational pathology. These models can serve as backbones for region-of-interest (ROI)…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Jiawen Li , Jiali Hu , Xitong Ling , Yongqiang Lv , Yuxuan Chen , Yizhi Wang , Tian Guan , Yifei Liu , Yonghong He

This paper proposes Comprehensive Pathology Language Image Pre-training (CPLIP), a new unsupervised technique designed to enhance the alignment of images and text in histopathology for tasks such as classification and segmentation. This…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Sajid Javed , Arif Mahmood , Iyyakutti Iyappan Ganapathi , Fayaz Ali Dharejo , Naoufel Werghi , Mohammed Bennamoun

Vision transformers (ViTs) can be trained using various learning paradigms, from fully supervised to self-supervised. Diverse training protocols often result in significantly different feature spaces, which are usually compared through…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Johanna Vielhaben , Dilyara Bareeva , Jim Berend , Wojciech Samek , Nils Strodthoff

As many algorithms depend on a suitable representation of data, learning unique features is considered a crucial task. Although supervised techniques using deep neural networks have boosted the performance of representation learning, the…

Computer Vision and Pattern Recognition · Computer Science 2020-09-07 Milad Sikaroudi , Amir Safarpoor , Benyamin Ghojogh , Sobhan Shafiei , Mark Crowley , H. R. Tizhoosh

Foundation vision encoders such as CLIP and DINOv2, trained on web-scale data, exhibit strong transfer performance across tasks and datasets. However, medical imaging foundation models remain constrained by smaller datasets, limiting our…