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The rapid digitization of histopathology slides has opened up new possibilities for computational tools in clinical and research workflows. Among these, content-based slide retrieval stands out, enabling pathologists to identify…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Hongyi Wang , Zhengjie Zhu , Jiabo Ma , Fang Wang , Yue Shi , Bo Luo , Jili Wang , Qiuyu Cai , Xiuming Zhang , Yen-Wei Chen , Lanfen Lin , Hao Chen

Visual recognition in low-data regimes requires deep neural networks to learn generalized representations from limited training samples. Recently, CLIP-based methods have shown promising few-shot performance benefited from the contrastive…

Computer Vision and Pattern Recognition · Computer Science 2023-03-06 Renrui Zhang , Xiangfei Hu , Bohao Li , Siyuan Huang , Hanqiu Deng , Hongsheng Li , Yu Qiao , Peng Gao

Clinical variant classification of pathogenic versus benign genetic variants remains a pivotal challenge in clinical genetics. Recently, the proposition of protein language models has improved the generic variant effect prediction (VEP)…

Genomics · Quantitative Biology 2023-11-09 Huixin Zhan , Zijun Zhang

Whole slide imaging is fundamental to biomedical microscopy and computational pathology. Previously, learning representations for gigapixel-sized whole slide images (WSIs) has relied on multiple instance learning with weak labels, which do…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Xinhai Hou , Cheng Jiang , Akhil Kondepudi , Yiwei Lyu , Asadur Chowdury , Honglak Lee , Todd C. Hollon

Vision-transformers (ViTs) and large-scale convolution-neural-networks (CNNs) have reshaped computer vision through pretrained feature representations that enable strong transfer learning for diverse tasks. However, their efficiency as…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Alon Kaya , Igal Bilik , Inna Stainvas

Foundation models in healthcare have largely adopted self supervised pretraining objectives inherited from natural language processing and computer vision, emphasizing reconstruction and large scale representation learning prior to…

Machine Learning · Computer Science 2026-03-24 Yang Zhang , Li Fan , Samuel Lawrence , Shi Li

Vision-language models such as CLIP have shown impressive capabilities in encoding texts and images into aligned embeddings, enabling the retrieval of multimodal data in a shared embedding space. However, these embedding-based models still…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Timothy Ossowski , Ming Jiang , Junjie Hu

There is substantial interest in developing artificial intelligence systems to support radiologists across tasks ranging from segmentation to report generation. Existing computed tomography (CT) foundation models have largely focused on…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Rubén Moreno-Aguado , Alba Magallón , Victor Moreno , Yingying Fang , Guang Yang

We study parity features as representations that can be evaluated entirely classically once the binary or quantized input representation and parity words are fixed, particularly when labels depend on higher-order feature interactions or…

With the rapid development of computational pathology, many AI-assisted diagnostic tasks have emerged. Cellular nuclei segmentation can segment various types of cells for downstream analysis, but it relies on predefined categories and lacks…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Chunlin Zhong , Shuang Hao , Junhua Wu , Xiaona Chang , Jiwei Jiang , Xiu Nie , He Tang , Xiang Bai

Reproducibility remains a critical challenge in foundation model training for histopathology, often hindered by software randomness, hardware non-determinism, and inconsistent hyperparameter reporting. To investigate these issues, we…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Usman Afzaal , Ziyu Su , Usama Sajjad , Hao Lu , Mostafa Rezapour , Metin Nafi Gurcan , Muhammad Khalid Khan Niazi

Recent years have witnessed a significant increase in the performance of Vision and Language tasks. Foundational Vision-Language Models (VLMs), such as CLIP, have been leveraged in multiple settings and demonstrated remarkable performance…

Computer Vision and Pattern Recognition · Computer Science 2024-03-04 Santiago Castro , Amir Ziai , Avneesh Saluja , Zhuoning Yuan , Rada Mihalcea

The recent surge of foundation models in computer vision and natural language processing opens up perspectives in utilizing multi-modal clinical data to train large models with strong generalizability. Yet pathological image datasets often…

Computer Vision and Pattern Recognition · Computer Science 2023-07-28 Yunkun Zhang , Jin Gao , Mu Zhou , Xiaosong Wang , Yu Qiao , Shaoting Zhang , Dequan Wang

Leaf disease identification plays a pivotal role in smart agriculture. However, many existing studies still struggle to integrate image and textual modalities to compensate for each other's limitations. Furthermore, many of these approaches…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Khang Nguyen Quoc , Lan Le Thi Thu , Luyl-Da Quach

Asymmetric appearance between positive pair effectively reduces the risk of representation degradation in contrastive learning. However, there are still a mass of appearance similarities between positive pair constructed by the existing…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Chengchao Shen , Jianzhong Chen , Shu Wang , Hulin Kuang , Jin Liu , Jianxin Wang

We introduce CAN, a simple, efficient and scalable method for self-supervised learning of visual representations. Our framework is a minimal and conceptually clean synthesis of (C) contrastive learning, (A) masked autoencoders, and (N) the…

Computer Vision and Pattern Recognition · Computer Science 2022-11-01 Shlok Mishra , Joshua Robinson , Huiwen Chang , David Jacobs , Aaron Sarna , Aaron Maschinot , Dilip Krishnan

Visual imagery does not consist of solitary objects, but instead reflects the composition of a multitude of fluid concepts. While there have been great advances in visual representation learning, such advances have focused on building…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Austin Stone , Hagen Soltau , Robert Geirhos , Xi Yi , Ye Xia , Bingyi Cao , Kaifeng Chen , Abhijit Ogale , Jonathon Shlens

The landscape of publicly available vision foundation models (VFMs), such as CLIP and Segment Anything Model (SAM), is expanding rapidly. VFMs are endowed with distinct capabilities stemming from their pre-training objectives. For instance,…

Motivation: Digitization of pathology laboratories through digital slide scanners and advances in deep learning approaches for objective histological assessment have resulted in rapid progress in the field of computational pathology (CPath)…

Machine Learning · Computer Science 2022-01-31 Alex Foote , Amina Asif , Nasir Rajpoot , Fayyaz Minhas

Computational pathology holds substantial promise for improving diagnosis and guiding treatment decisions. Recent pathology foundation models enable the extraction of rich patch-level representations from large-scale whole-slide images…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Xiangde Luo , Jinxi Xiang , Yuanfeng Ji , Ruijiang Li