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Attosecond pulses from X-ray free-electron laser (XFEL) have opened new opportunities for probing ultrafast electronic dynamics on the Angstrom--attosecond spatiotemporal scale. Most attosecond XFEL concepts rely on generating an ultrashort…

Accelerator Physics · Physics 2026-04-22 Chenzhi Xu , Jiawei Yan , Ye Chen , Winfried Decking , Marc Guetg , Tianyun Long , Bingyang Yan , Haixiao Deng

The European X-ray Free Electron Laser (XFEL) will deliver 27000 fully coherent, high brilliance X-ray pulses per second each with a duration below 100 fs. This will allow the recording of diffraction patterns of single molecules and the…

Instrumentation and Detectors · Physics 2015-06-03 J. Schwandt , E. Fretwurst , R. Klanner , I. Pintilie , J. Zhang

The extremely high power densities and short durations of single pulses of x-ray free electron lasers (XFELs) have opened new opportunities in atomic physics, where complex excitation-relaxation chains allow for high ionization states in…

Other Condensed Matter · Physics 2018-01-24 Oliver R. Hoidn , Gerald T. Seidler

We present a novel, highly versatile, and self-referenced arrival time monitor for measuring the femtosecond time delay between a hard X-ray pulse from a free-electron laser and an optical laser pulse, measured directly on the same sample…

Immunofluorescent (IF) imaging is crucial for visualizing biomarker expressions, cell morphology and assessing the effects of drug treatments on sub-cellular components. IF imaging needs extra staining process and often requiring cell…

The ingenious idea of single molecule imaging by hard x-ray Free Electron Laser (X-FEL) pulses was recently proposed by Neutze et al. [Nature,406,752(2000)]. However, in their numerical modelling of the Coulomb explosion several…

Condensed Matter · Physics 2009-11-10 Zoltan Jurek , Gabor Oszlanyi , Gyula Faigel

Structured illumination can reject out-of-focus signal from a sample, enabling high-speed and high-contrast imaging over large areas with widefield detection optics. Currently, this optical-sectioning technique is limited by image…

Lensless X-ray imaging provides element-specific nanoscale insights into thick samples beyond the reach of conventional light and electron microscopy. Coherent diffraction imaging (CDI) methods, such as ptychographic tomography, can recover…

X-ray diffraction of silicon irradiated with tightly focused femtosecond x-ray pulses (photon energy: 11.5 keV, pulse duration: 6 fs) was measured at various x-ray intensities up to $4.6\times10^{19}$ W/cm$^2$. The measurement reveals that…

Ultrafast phenomena on a femtosecond timescale are commonly examined by pump-probe experiments. This implies multiple measurements where the sample under investigation is pumped with a short light pulse and then probed with a second pulse…

Optical diffraction tomography is an indispensable tool for studying objects in three-dimensions due to its ability to accurately reconstruct scattering objects. Until now this technique has been limited to coherent light because spatial…

X-ray Absorption Spectroscopy (XAS) is a widely used X-ray diagnostic method. While synchrotrons have large communities of XAS users, its use on X-Ray Free Electron Lasers (XFEL) facilities has been rather limited. At a first glance, the…

Instrumentation and Detectors · Physics 2020-05-05 M. Harmand , M. Cammarata , M. Chollet , A. G Krygier , H. T. Lemke , D. Zhu

Multi-exposure image fusion is a method for producing an image with a wide dynamic range by fusing multiple images taken under various exposure values. In this paper, we discuss color distortion included in fused images, and propose a novel…

Image and Video Processing · Electrical Eng. & Systems 2019-07-29 Artit Visavakitcharoen , Yuma Kinoshita , Hitoshi Kiya

The ability to arbitrarily dial in amplitudes and phases enables the fundamental quantum state operations pioneered for microwaves and then infrared and visible wavelengths during the second half of the last century. Self-seeded X-ray…

We report the development and detailed calibration of a multiphoton fluorescence lifetime imaging system (FLIM) using a streak camera. The present system is versatile with high spatial (0.2 micron) and temporal (50 psec) resolution and…

Quantitative Methods · Quantitative Biology 2009-11-10 R. V. Krishnan , H. Saitoh , H. Terada , V. E. Centonze , B. Herman

In modern high-gain free-electron lasers, ultra-fast photon pulses designed for studying chemical, atomic and biological systems are generated from a serial of behaviors of high-brightness electron beam at the time-scale ranging from…

Accelerator Physics · Physics 2015-10-22 Guanglei Wang , Meng Zhang , Wei Zhang , Haixiao Deng , Xueming Yang

Many experiments in biological and medical sciences currently use multiphoton microscopy as a core imaging technique. To date, solid-state lasers are most commonly used as excitation beam sources. However, the most demanding applications…

Volume Free Electron Laser (VFEL) was proposed in [1-4]. It can operate in the wide spectral range from microwaves to X-rays. To simulate the processes which take place in VFEL the superradiance from a short electron pulse moving in a…

Optics · Physics 2016-09-08 Vladimir G. Baryshevsky , Konstantin G. Batrakov

The advent of X-ray Free Electron Lasers promises the possibility to determine the structure of individual particles such as microcrystallites, viruses and biomolecules from single-shot diffraction snapshots obtained before the particle is…

Soft Condensed Matter · Physics 2010-05-06 Brian Moths , Abbas Ourmazd
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