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The recent development of multimodal single-cell technology has made the possibility of acquiring multiple omics data from individual cells, thereby enabling a deeper understanding of cellular states and dynamics. Nevertheless, the…

Genomics · Quantitative Biology 2023-10-16 Wenzhuo Tang , Hongzhi Wen , Renming Liu , Jiayuan Ding , Wei Jin , Yuying Xie , Hui Liu , Jiliang Tang

A fundamental question in interpretability research is to what extent neural networks, particularly language models, implement reusable functions through subnetworks that can be composed to perform more complex tasks. Recent advances in…

Machine Learning · Computer Science 2025-06-24 Philipp Mondorf , Sondre Wold , Barbara Plank

This paper proposes a transformer over transformer framework, called Transformer$^2$, to perform neural text segmentation. It consists of two components: bottom-level sentence encoders using pre-trained transformers, and an upper-level…

Computation and Language · Computer Science 2021-10-15 Kelvin Lo , Yuan Jin , Weicong Tan , Ming Liu , Lan Du , Wray Buntine

Spatially resolved transcriptomics brings exciting breakthroughs to single-cell analysis by providing physical locations along with gene expression. However, as a cost of the extremely high spatial resolution, the cellular level spatial…

Genomics · Quantitative Biology 2024-02-19 Hongzhi Wen , Wenzhuo Tang , Wei Jin , Jiayuan Ding , Renming Liu , Xinnan Dai , Feng Shi , Lulu Shang , Hui Liu , Yuying Xie

Neural network models have achieved high performance on a wide variety of complex tasks, but the algorithms that they implement are notoriously difficult to interpret. It is often necessary to hypothesize intermediate variables involved in…

Computation and Language · Computer Science 2025-02-13 Michael A. Lepori , Thomas Serre , Ellie Pavlick

Large Language Models (LLMs), powered by Transformers, have demonstrated human-like intelligence capabilities, yet their underlying mechanisms remain poorly understood. This paper presents a novel framework for interpreting LLMs as…

Computation and Language · Computer Science 2025-04-16 Phill Kyu Rhee

Sequence-to-Sequence (S2S) models have achieved remarkable success on various text generation tasks. However, learning complex structures with S2S models remains challenging as external neural modules and additional lexicons are often…

Computation and Language · Computer Science 2023-02-07 Han He , Jinho D. Choi

Circuit discovery aims to explain how language models (LMs) implement a specific task by localizing and interpreting a circuit, a computational subgraph responsible for the LM's behavior. Existing circuit discovery methods are…

Artificial Intelligence · Computer Science 2026-05-12 Daking Rai , Mor Geva , Ziyu Yao

Learning multiscale Transformer models has been evidenced as a viable approach to augmenting machine translation systems. Prior research has primarily focused on treating subwords as basic units in developing such systems. However, the…

Computation and Language · Computer Science 2023-05-29 Bei Li , Yi Jing , Xu Tan , Zhen Xing , Tong Xiao , Jingbo Zhu

Single-cell foundation models such as scGPT represent a significant advancement in single-cell omics, with an ability to achieve state-of-the-art performance on various downstream biological tasks. However, these models are inherently…

Machine Learning · Computer Science 2025-07-15 Steven Palayew , Bo Wang , Gary Bader

Pretrained bidirectional Transformers, such as BERT, have achieved significant improvements in a wide variety of language understanding tasks, while it is not straightforward to directly apply them for natural language generation. In this…

Computation and Language · Computer Science 2021-10-27 Hangbo Bao , Li Dong , Wenhui Wang , Nan Yang , Furu Wei

The combination of Transformer-based encoders with contrastive learning represents the current mainstream paradigm for sentence representation learning. This paradigm is typically based on the hidden states of the last Transformer block of…

Computation and Language · Computer Science 2025-08-26 Jianxiang Zang , Nijia Mo , Yonda Wei , Meiling Ning , Hui Liu

While transformer models exhibit strong capabilities on linguistic tasks, their complex architectures make them difficult to interpret. Recent work has aimed to reverse engineer transformer models into human-readable representations called…

Computation and Language · Computer Science 2024-10-08 Michael Lan , Philip Torr , Fazl Barez

Recent advances in speech language models (LLMs) have extended textual LLMs to the speech domain, but balancing speech understanding and generation remains challenging, especially with codec-based representations. We propose a continual…

Audio and Speech Processing · Electrical Eng. & Systems 2025-12-01 Jiatong Shi , Chunlei Zhang , Jinchuan Tian , Junrui Ni , Hao Zhang , Shinji Watanabe , Dong Yu

Automatic Music Transcription has seen significant progress in recent years by training custom deep neural networks on large datasets. However, these models have required extensive domain-specific design of network architectures,…

Sound · Computer Science 2021-07-21 Curtis Hawthorne , Ian Simon , Rigel Swavely , Ethan Manilow , Jesse Engel

Through considerable effort and intuition, several recent works have reverse-engineered nontrivial behaviors of transformer models. This paper systematizes the mechanistic interpretability process they followed. First, researchers choose a…

Machine Learning · Computer Science 2023-10-31 Arthur Conmy , Augustine N. Mavor-Parker , Aengus Lynch , Stefan Heimersheim , Adrià Garriga-Alonso

Deciphering how DNA sequence encodes gene regulation remains a central challenge in biology. Advances in machine learning and functional genomics have enabled sequence-to-function (seq2func) models that predict molecular regulatory readouts…

Genomics · Quantitative Biology 2026-02-03 Masayuki Nagai , Alan E. Murphy , Kaeli Rizzo , Peter K. Koo

Do transformers, when trained on sequential reasoning traces, build internal models of the underlying task? And if so, does the structure of those internal representations mirror the structure of the domain? We train an 8-layer transformer…

Machine Learning · Computer Science 2026-05-20 Roman Kniazev , Nathanaël Fijalkow

Implementing Boolean functions with circuits consisting of logic gates is fundamental in digital computer design. However, the implemented circuit must be exactly equivalent, which hinders generative neural approaches on this task due to…

Machine Learning · Computer Science 2025-02-04 Xihan Li , Xing Li , Lei Chen , Xing Zhang , Mingxuan Yuan , Jun Wang

The enhancement of spectrum efficiency and the realization of secure spectrum utilization are critically dependent on spectrum cognition. However, existing spectrum cognition methods often exhibit limited generalization and suboptimal…

Signal Processing · Electrical Eng. & Systems 2025-08-12 Chunyu Liu , Hao Zhang , Wei Wu , Fuhui Zhou , Qihui Wu , Derrick Wing Kwan Ng , Chan-Byoung Chae