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Specialized foundation models are beginning to emerge in various medical subdomains, but pretraining methodologies and parametric scaling with the size of the pretraining dataset are rarely assessed systematically and in a like-for-like…

Signal Processing · Electrical Eng. & Systems 2026-05-13 M A Al-Masud , Nils Strodthoff

Conventional task-specific electrocardiogram (ECG) analysis models require large annotated datasets to train. Foundation models mitigate this burden by leveraging self-supervised pretraining; however, the scarcity of open-weight ECG…

Machine Learning · Computer Science 2025-06-02 Kaden McKeen , Sameer Masood , Augustin Toma , Barry Rubin , Bo Wang

Transthoracic echocardiography is the reference standard for confirming structural heart disease (SHD), but first-line screening is limited by cost, workflow burden, and specialist availability. We evaluated whether open pretrained…

To handle the scarcity and heterogeneity of electroencephalography (EEG) data for Brain-Computer Interface (BCI) tasks, and to harness the power of large publicly available data sets, we propose Neuro-GPT, a foundation model consisting of…

Machine Learning · Computer Science 2024-03-05 Wenhui Cui , Woojae Jeong , Philipp Thölke , Takfarinas Medani , Karim Jerbi , Anand A. Joshi , Richard M. Leahy

Timely access to laboratory values is critical for clinical decision-making, yet current approaches rely on invasive venous sampling and are intrinsically delayed. Electrocardiography (ECG), as a non-invasive and widely available signal,…

Machine Learning · Computer Science 2025-10-28 Yujie Xiao , Gongzhen Tang , Wenhui Liu , Jun Li , Guangkun Nie , Zhuoran Kan , Deyun Zhang , Qinghao Zhao , Shenda Hong

Electrocardiogram (ECG) is widely used in healthcare applications, such as arrhythmia detection and sleep monitoring, making accurate ECG analysis critically essential. Traditional deep learning models for ECG are task-specific, with…

Signal Processing · Electrical Eng. & Systems 2025-10-14 Yu Han , Vittorio Murino , Xiaofeng Liu , Xiang Zhang , Cheng Ding

The electrocardiogram (ECG) is a cost-effective, highly accessible and widely employed diagnostic tool. With the advent of Foundation Models (FMs), the field of AI-assisted ECG interpretation has begun to evolve, as they enable model reuse…

Artificial Intelligence · Computer Science 2026-01-30 Francesca Filice , Edoardo De Rose , Simone Bartucci , Francesco Calimeri , Simona Perri

Electroencephalography (EEG) foundation models have recently emerged as a promising paradigm for brain-computer interfaces (BCIs), aiming to learn transferable neural representations from large-scale heterogeneous recordings. Despite rapid…

Machine Learning · Computer Science 2026-02-06 Dingkun Liu , Yuheng Chen , Zhu Chen , Zhenyao Cui , Yaozhi Wen , Jiayu An , Jingwei Luo , Dongrui Wu

Artificial intelligence (AI) has demonstrated significant potential in ECG analysis and cardiovascular disease assessment. Recently, foundation models have played a remarkable role in advancing medical AI. The development of an ECG…

Machine Learning · Computer Science 2025-08-05 Jun Li , Aaron Aguirre , Junior Moura , Che Liu , Lanhai Zhong , Chenxi Sun , Gari Clifford , Brandon Westover , Shenda Hong

Neural network models have demonstrated impressive performance in predicting pathologies and outcomes from the 12-lead electrocardiogram (ECG). However, these models often need to be trained with large, labelled datasets, which are not…

Machine Learning · Computer Science 2022-04-12 Aniruddh Raghu , Divya Shanmugam , Eugene Pomerantsev , John Guttag , Collin M. Stultz

Foundation models hold promise for transforming AI in healthcare by providing modular components that are easily adaptable to downstream healthcare tasks, making AI development more scalable and cost-effective. Structured EHR foundation…

Large-scale foundation models for EEG signals offer a promising path to generalizable brain-computer interface (BCI) applications, but they often suffer from misalignment between pretraining objectives and downstream tasks, as well as…

Machine Learning · Computer Science 2025-10-03 Suli Wang , Yangshen Deng , Zhenghua Bao , Xinyu Zhan , Yiqun Duan

Intracranial electrocorticography (ECoG) offers high-signal-to-noise access to cortical activity for brain-computer interfaces, yet limited per-patient data has led most prior work to rely on small, subject-specific decoders that neglect…

Artificial Intelligence · Computer Science 2026-05-12 Liuyin Yang , Qiang Sun , Bob Van Dyck , Eva Calvo Merino , Marc M. Van Hulle

Electroencephalography (EEG) signals provide critical insights for applications in disease diagnosis and healthcare. However, the scarcity of labeled EEG data poses a significant challenge. Foundation models offer a promising solution by…

Machine Learning · Computer Science 2025-02-25 Limin Wang , Toyotaro Suzumura , Hiroki Kanezashi

We introduce the notion of heterogeneous calibration that applies a post-hoc model-agnostic transformation to model outputs for improving AUC performance on binary classification tasks. We consider overconfident models, whose performance is…

Machine Learning · Statistics 2022-02-11 David Durfee , Aman Gupta , Kinjal Basu

The 12-lead electrocardiogram (ECG) is a long-standing diagnostic tool. Yet machine learning for ECG interpretation remains fragmented, often limited to narrow tasks or datasets. FMs promise broader adaptability, but fundamental questions…

Signal Processing · Electrical Eng. & Systems 2026-03-05 M A Al-Masud , Juan Miguel Lopez Alcaraz , Nils Strodthoff

In the process of patient diagnosis, non-invasive measurements are widely used due to their low risks and quick results. Electrocardiogram (ECG), as a non-invasive method to collect heart activities, is used to diagnose cardiac conditions.…

Machine Learning · Computer Science 2025-12-11 Yuhao Xu , Jiaying Lu , Sirui Ding , Defu Cao , Xiao Hu , Carl Yang

Evaluating foundation models under appropriate adaptation settings is essential for understanding the quality and transferability of the learned representations. Recent EEG foundation models have demonstrated promising transfer capabilities…

Machine Learning · Computer Science 2026-05-28 Aditya Kommineni , Emily Zhou , Kleanthis Avramidis , Tiantian Feng , Shrikanth Narayanan

This study introduces OpenECG, a large-scale benchmark of 1.2 million 12-lead ECG recordings from nine centers, to evaluate ECG foundation models (ECG-FMs) trained on public datasets. We investigate three self-supervised learning methods…

Machine Learning · Computer Science 2025-03-04 Zhijiang Wan , Qianhao Yu , Jia Mao , Wenfeng Duan , Cheng Ding

Electrocardiograms (ECGs) are inexpensive, widely used, and well-suited to deep learning. Recently, interest has grown in developing foundation models for ECGs - models that generalise across diverse downstream tasks. However, consistent…

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