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Glaucoma is the second leading cause of blindness all over the world, with approximately 60 million cases reported worldwide in 2010. If undiagnosed in time, glaucoma causes irreversible damage to the optic nerve leading to blindness. The…

Computer Vision and Pattern Recognition · Computer Science 2018-05-01 Artem Sevastopolsky

Glaucoma is a major cause of irreversible blindness, with significant diagnostic subjectivity. This inherent uncertainty, combined with the overconfidence of models optimized solely for accuracy can lead to fatal issues such as…

Image and Video Processing · Electrical Eng. & Systems 2025-11-04 Taejin Jeong , Joohyeok Kim , Jaehoon Joo , Seong Jae Hwang

Glaucoma is a leading cause of irreversible blindness, but early detection can significantly improve treatment outcomes. Traditional diagnostic methods are often invasive and require specialized equipment. In this work, we present a deep…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Rishiraj Paul Chowdhury , Nirmit Shekar Karkera

Accurate diagnosis of glaucoma is challenging, as early-stage changes are subtle and often lack clear structural or appearance cues. Most existing approaches rely on a single modality, such as fundus or optical coherence tomography (OCT),…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Zhiwei Wang , Yuxing Li , Meilu Zhu , Defeng He , Edmund Y. Lam

Glaucoma is the leading cause of preventable, irreversible blindness world-wide. The disease can remain asymptomatic until severe, and an estimated 50%-90% of people with glaucoma remain undiagnosed. Glaucoma screening is recommended for…

A major cause of irreversible visual impairment is angle-closure glaucoma, which can be screened through imagery from Anterior Segment Optical Coherence Tomography (AS-OCT). Previous computational diagnostic techniques address this…

Computer Vision and Pattern Recognition · Computer Science 2018-09-11 Huazhu Fu , Yanwu Xu , Stephen Lin , Damon Wing Kee Wong , Baskaran Mani , Meenakshi Mahesh , Tin Aung , Jiang Liu

Glaucoma is a severe eye disease that is known to deteriorate optic never fibers, causing cup size to increase, which could result in permanent loss of vision. Glaucoma is the second leading cause of blindness after cataract, but glaucoma…

Image and Video Processing · Electrical Eng. & Systems 2021-04-09 Maleeha Khalid Khan , Syed Muhammad Anwar

Early and accurate detection of glaucoma is critical to prevent irreversible vision loss. However, existing methods often rely on unimodal data and lack interpretability, limiting their clinical utility. In this paper, we present GlaBoost,…

Machine Learning · Computer Science 2025-08-07 Cheng Huang , Weizheng Xie , Karanjit Kooner , Tsengdar Lee , Jui-Kai Wang , Jia Zhang

Glaucoma is one of the primary causes of vision loss around the world, necessitating accurate and efficient detection methods. Traditional manual detection approaches have limitations in terms of cost, time, and subjectivity. Recent…

Image and Video Processing · Electrical Eng. & Systems 2023-11-03 Aized Amin Soofi , Fazal-e-Amin

Automated segmentation of the optic cup and disk on retinal fundus images is fundamental for the automated detection / analysis of glaucoma. Traditional segmentation approaches depend heavily upon hand-crafted features and a priori…

Computer Vision and Pattern Recognition · Computer Science 2019-02-14 Lei Bi , Yuyu Guo , Qian Wang , Dagan Feng , Michael Fulham , Jinman Kim

Glaucoma is a top cause of irreversible blindness globally, making early detection and longitudinal follow-up pivotal to preventing permanent vision loss. Current screening and progression assessment, however, rely on single tests or…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Wenbin Wei , Suyuan Yao , Cheng Huang , Xiangyu Gao

Glaucoma is an irreversible ocular disease and is the second leading cause of visual disability worldwide. Slow vision loss and the asymptomatic nature of the disease make its diagnosis challenging. Early detection is crucial for preventing…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Gyanendar Manohar , Ruairi O'Reilly

Background/Aims: Standard Automated Perimetry (SAP) is the gold standard to monitor visual field (VF) loss in glaucoma management, but is prone to intra-subject variability. We developed and validated a deep learning (DL) regression model…

Image and Video Processing · Electrical Eng. & Systems 2021-06-08 Ruben Hemelings , Bart Elen , João Barbosa Breda , Erwin Bellon , Matthew B Blaschko , Patrick De Boever , Ingeborg Stalmans

Feature generation is a critical step in machine learning, aiming to enhance model performance by capturing complex relationships within the data and generating meaningful new features. Traditional feature generation methods heavily rely on…

Machine Learning · Computer Science 2025-05-29 Wanfu Gao , Zengyao Man , Zebin He , Yuhao Tang , Jun Gao , Kunpeng Liu

Glaucoma is the leading cause of irreversible blindness worldwide and poses significant diagnostic challenges due to its reliance on subjective evaluation. However, recent advances in computer vision and deep learning have demonstrated the…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Mona Ashtari-Majlan , Mohammad Mahdi Dehshibi , David Masip

Preprint Note: This is the author preprint version of a paper accepted for presentation at the IISE Annual Conference & Expo 2025. The final version will appear in the official proceedings. Diabetic retinopathy (DR) is a leading cause of…

Machine Learning · Computer Science 2025-10-02 Mahyar Mahmoudi , Tieming Liu

Glaucoma is a complex group of eye diseases marked by optic nerve damage, commonly linked to elevated intraocular pressure and biomarkers like retinal nerve fiber layer thickness. Understanding how these biomarkers interact is crucial for…

Image and Video Processing · Electrical Eng. & Systems 2025-09-24 Cheng Huang , Weizheng Xie , Tsengdar Lee , Karanjit Kooner , Ning Zhang , Jia Zhang

Automatic evaluation of the retinal fundus image is emerging as one of the most important tools for early detection and treatment of progressive eye diseases like Glaucoma. Glaucoma results to a progressive degeneration of vision and is…

Image and Video Processing · Electrical Eng. & Systems 2021-12-13 Sneha Dasgupta , Rishav Mukherjee , Kaushik Dutta , Anindya Sen

Glaucoma is one of the most severe eye diseases, characterized by rapid progression and leading to irreversible blindness. It is often the case that diagnostics is carried out when one's sight has already significantly degraded due to the…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Ahmed Al Mahrooqi , Dmitrii Medvedev , Rand Muhtaseb , Mohammad Yaqub

With the advancements in medical artificial intelligence (AI), fundus image classifiers are increasingly being applied to assist in ophthalmic diagnosis. While existing classification models have achieved high accuracy on specific fundus…

Computer Vision and Pattern Recognition · Computer Science 2025-04-02 Yuzhuo Zhou , Chi Liu , Sheng Shen , Siyu Le , Liwen Yu , Sihan Ouyang , Zongyuan Ge