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Artificial intelligence holds great promise for expanding access to expert medical knowledge and reasoning. However, most evaluations of language models rely on static vignettes and multiple-choice questions that fail to reflect the…
Biased AI-generated medical advice and misdiagnoses can jeopardize patient safety, making the integrity of AI in healthcare more critical than ever. As Large Language Models (LLMs) take on a growing role in medical decision-making,…
The clinical adoption of artificial intelligence (AI) in medical diagnostics is critically hampered by its black-box nature, which prevents clinicians from verifying the rationale behind automated decisions. To overcome this fundamental…
Large language models (LLMs) are increasingly used for diagnostic tasks in medicine. In clinical practice, the correct diagnosis can rarely be immediately inferred from the initial patient presentation alone. Rather, reaching a diagnosis…
Background: Globally we face a projected shortage of 11 million healthcare practitioners by 2030, and administrative burden consumes 50% of clinical time. Artificial intelligence (AI) has the potential to help alleviate these problems.…
Diagnostic errors in healthcare persist as a critical challenge, with increasing numbers of patients turning to online resources for health information. While AI-powered healthcare chatbots show promise, there exists no standardized and…
Evaluating medical AI systems using expert clinician panels is costly and slow, motivating the use of large language models (LLMs) as alternative adjudicators. Here, we evaluate an LLM jury composed of three frontier AI models scoring 3333…
We present PULSE, a medical reasoning agent that combines a domain-tuned large language model with scientific literature retrieval to support diagnostic decision-making in complex real-world cases. To evaluate its capabilities, we curated a…
Leveraging large historical data in electronic health record (EHR), we developed Doctor AI, a generic predictive model that covers observed medical conditions and medication uses. Doctor AI is a temporal model using recurrent neural…
Large language models (LLMs) have shown considerable potential in supporting medical diagnosis. However, their effective integration into clinical workflows is hindered by physicians' difficulties in perceiving and trusting LLM…
Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…
Heart diseases remain a leading cause of morbidity and mortality worldwide, necessitating accurate and trustworthy differential diagnosis. However, existing artificial intelligence-based diagnostic methods are often limited by insufficient…
The emergence of deep research systems presents significant capabilities in problem-solving, extending from basic queries to sophisticated research tasks. However, existing benchmarks primarily evaluate these systems as agents for web…
Artificial intelligence (AI) can automatically delineate lesions on computed tomography (CT) and generate radiology report content, yet progress is limited by the scarcity of publicly available CT datasets with lesion-level annotations. To…
Modern science is reaching a critical inflection point. Instruments across disciplines, from particle physics and astronomy to genomics and climate modeling, now produce data of such scale, diversity, and interdependence that traditional…
Generative medical AI now appears fluent and knowledgeable enough to resemble clinical intelligence, encouraging the belief that scaling will make it safe. But clinical reasoning is not text generation. It is a responsibility-bound process…
Identifying type 2 diabetes mellitus can be challenging, particularly for primary care physicians. Clinical decision support systems incorporating artificial intelligence (AI-CDSS) can assist medical professionals in diagnosing type 2…
Large language models (LLMs) are increasingly used in clinical settings, raising concerns about racial bias in both generated medical text and clinical reasoning. Existing studies have identified bias in medical LLMs, but many focus on…
Large language models are increasingly being assembled into medical multi-agent systems that emulate multidisciplinary consultation through specialist roles, peer review and consensus formation. In clinical decision support, however,…
Patients must possess the knowledge necessary to actively participate in their care. We present NoteAid-Chatbot, a conversational AI that promotes patient understanding via a novel 'learning as conversation' framework, built on a…