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Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to…

Quantitative Methods · Quantitative Biology 2025-09-09 James Boyle , Gregory Hamm , Eleanor Williams , Robin JG Hartman , Magnus Soderburg , Ian Henry , Michael Casey

Understanding the dependence and interplay between architecture and function in biological networks has great relevance to disease progression, biological fabrication and biological systems in general. We propose methods to assess the…

Quantitative Methods · Quantitative Biology 2009-10-17 Soumen Roy , Vladimir Filkov

The leaves of angiosperms contain highly complex venation networks consisting of recursively nested, hierarchically organized loops. We describe a new phenotypic trait of reticulate vascular networks based on the topology of the nested…

Quantitative Methods · Quantitative Biology 2016-06-23 Henrik Ronellenfitsch , Jana Lasser , Douglas C. Daly , Eleni Katifori

Persistent homology (PH) has recently emerged as a powerful tool for extracting topological features. Integrating PH into machine learning and deep learning models enhances topology awareness and interpretability. However, most PH methods…

Machine Learning · Computer Science 2026-01-05 Xinyang Chen , Amaël Broustet , Guanyuan Zeng , Cheng He , Guoting Chen

Algorithms for persistent homology and zigzag persistent homology are well-studied for persistence modules where homomorphisms are induced by inclusion maps. In this paper, we propose a practical algorithm for computing persistence under…

Computational Geometry · Computer Science 2014-03-26 Tamal K. Dey , Fengtao Fan , Yusu Wang

Persistent homology has recently emerged as a powerful technique in topological data analysis for analyzing the emergence and disappearance of topological features throughout a filtered space, shown via persistence diagrams. Additionally,…

Algebraic Topology · Mathematics 2016-12-16 Nicholas A. Scoville , Karthik Yegnesh

Persistent homology is constrained to purely topological persistence while multiscale graphs account only for geometric information. This work introduces persistent spectral theory to create a unified low-dimensional multiscale paradigm for…

Combinatorics · Mathematics 2019-12-13 Rui Wang , Duc Duy Nguyen , Guo-Wei Wei

Data quality is crucial for the successful training, generalization and performance of machine learning models. We propose to measure the quality of a subset concerning the dataset it represents, using topological data analysis techniques.…

Algebraic Topology · Mathematics 2024-10-01 Álvaro Torras-Casas , Eduardo Paluzo-Hidalgo , Rocio Gonzalez-Diaz

We use methods from topological data analysis to study the topological features of certain distributions of string vacua. Topological data analysis is a multi-scale approach used to analyze the topological features of a dataset by…

High Energy Physics - Theory · Physics 2016-04-20 Michele Cirafici

Localized patterns are coherent structures embedded in a quiescent state and occur in both discrete and continuous media across a wide range of applications. While it is well-understood how domain covering patterns (for example stripes and…

Pattern Formation and Solitons · Physics 2025-03-19 Jason J. Bramburger , Dan J. Hill , David J. B. Lloyd

Multicellular systems play a key role in bioprocess and biomedical engineering. Cell ensembles encountered in these setups show phenotypic variability like size and biochemical composition. As this variability may result in undesired…

Systems and Control · Computer Science 2018-07-16 Armin Küper , Robert Dürr , Steffen Waldherr

Such modern applications of topology as data analysis and digital image analysis have to deal with noise and other uncertainty. In this environment, topological spaces often appear equipped with a real valued function. Persistence is a…

Algebraic Topology · Mathematics 2011-05-02 Peter Saveliev

We give bounds for dimension 0 persistent homology and codimension 1 homology of Vietoris--Rips, alpha, and cubical complex filtrations from finite sets related by enrichment (adding new elements), sparsification (removing elements), and…

Algebraic Topology · Mathematics 2025-12-05 Jānis Lazovskis , Ran Levi , Juliano Morimoto

We propose a unified framework based on persistent homology (PH) to characterize both local and global structures in disordered systems. It can simultaneously generate local and global descriptors using the same algorithm and data…

Disordered Systems and Neural Networks · Physics 2025-11-03 An Wang , Li Zou

We apply persistent homology to the task of discovering and characterizing phase transitions, using lattice spin models from statistical physics for working examples. Persistence images provide a useful representation of the homological…

Statistical Mechanics · Physics 2020-12-03 Alex Cole , Gregory J. Loges , Gary Shiu

We analyze the properties of seven community food webs from a variety of environments--including freshwater, marine-freshwater interfaces and terrestrial environments. We uncover quantitative unifying patterns that describe the properties…

Disordered Systems and Neural Networks · Physics 2009-11-07 J. Camacho , R. Guimera , L. A. N. Amaral

We combine standard persistent homology with image persistent homology to define a novel way of characterizing shapes and interactions between them. In particular, we introduce: (1) a mixup barcode, which captures geometric-topological…

Algebraic Topology · Mathematics 2026-05-19 Hubert Wagner , Nickolas Arustamyan , Matthew Wheeler , Peter Bubenik

Continuous adaptation allows survival in an ever-changing world. Adjustments in the synaptic coupling strength between neurons are essential for this capability, setting us apart from simpler, hard-wired organisms. How these changes can be…

Neurons and Cognition · Quantitative Biology 2021-01-06 Jakob Jordan , Maximilian Schmidt , Walter Senn , Mihai A. Petrovici

Techniques from computational topology, in particular persistent homology, are becoming increasingly relevant for data analysis. Their stable metrics permit the use of many distance-based data analysis methods, such as multidimensional…

Algebraic Topology · Mathematics 2021-01-20 Bastian Rieck , Filip Sadlo , Heike Leitte

We propose a general theory for surface patterning in many different biological systems, including mite and insect cuticles, pollen grains, fungal spores, and insect eggs. The patterns of interest are often intricate and diverse, yet an…

Soft Condensed Matter · Physics 2016-06-01 Maxim O. Lavrentovich , Eric M. Horsley , Asja Radja , Alison M. Sweeney , Randall D. Kamien