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Rapid advance of experimental techniques provides an unprecedented in-depth view into complex developmental processes. Still, little is known on how the complexity of multicellular organisms evolved by elaborating developmental programs and…

Molecular Networks · Quantitative Biology 2021-07-16 Somya Mani , Tsvi Tlusty

Hyperuniform materials, characterized by their suppressed density fluctuations and vanishing structure factors as the wave number approaches zero, represent a unique state of matter that straddles the boundary between order and randomness.…

Disordered Systems and Neural Networks · Physics 2024-08-20 Yiwen Tang , Xinzhi Li , Dapeng Bi

Classification of large and dense networks based on topology is very difficult due to the computational challenges of extracting meaningful topological features from real-world networks. In this paper we present a computationally tractable…

Machine Learning · Computer Science 2022-02-04 Tananun Songdechakraiwut , Bryan M. Krause , Matthew I. Banks , Kirill V. Nourski , Barry D. Van Veen

Flexible mechanical metamaterials possess repeating structural motifs that imbue them with novel, exciting properties including programmability, anomalous elastic moduli and nonlinear and robust response. We address such structures via…

Soft Condensed Matter · Physics 2020-03-11 Adrien Saremi , Zeb Rocklin

We introduce a refinement of persistent homology that detects simple-homotopy-theoretic phenomena invisible to homology. Given a filtered simplicial complex, we define the Morse complexity profile as the minimal number of critical simplices…

Algebraic Topology · Mathematics 2026-04-14 Divya Ahuja , Jaya NN Iyer

Examining individual components of cellular systems has been successful in uncovering molecular reactions and interactions. However, the challenge lies in integrating these components into a comprehensive system-scale map. This difficulty…

Other Quantitative Biology · Quantitative Biology 2024-07-03 Nima Dehghani

In this paper we develop a novel Topological Data Analysis (TDA) approach for studying graph representations of time series of dynamical systems. Specifically, we show how persistent homology, a tool from TDA, can be used to yield a…

Chaotic Dynamics · Physics 2020-01-28 Audun Myers , Elizabeth Munch , Firas A. Khasawneh

Persistent homology computes the multiscale topology of a data set by using a sequence of discrete complexes. In this paper, we propose that persistent homology may be a useful tool for studying the structure of the landscape of string…

High Energy Physics - Theory · Physics 2019-04-24 Alex Cole , Gary Shiu

Persistent homology (PH) is a popular tool for topological data analysis that has found applications across diverse areas of research. It provides a rigorous method to compute robust topological features in discrete experimental…

Machine Learning · Computer Science 2023-07-19 Manu Aggarwal , Vipul Periwal

Modern deep neural networks have shown remarkable performance in medical image classification. However, such networks either emphasize pixel-intensity features instead of fundamental anatomical structures (e.g., those encoded by topological…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Pengfei Gu , Huimin Li , Haoteng Tang , Dongkuan , Xu , Erik Enriquez , DongChul Kim , Bin Fu , Danny Z. Chen

In this research, we introduce a novel methodology for the index tracking problem with sparse portfolios by leveraging topological data analysis (TDA). Utilizing persistence homology to measure the riskiness of assets, we introduce a…

Computational Engineering, Finance, and Science · Computer Science 2023-10-17 Anubha Goel , Puneet Pasricha , Juho Kanniainen

Biological cells can actively tune their intracellular architecture according to their overall shape. Here we explore the rheological implication of such coupling in a minimal model of a dense cellular material where each cell exerts an…

Soft Condensed Matter · Physics 2022-04-13 Shao-Zhen Lin , Matthias Merkel , Jean-François Rupprecht

Topological complexity is a homotopy invariant that measures the minimal number of continuous rules required for motion planning in a space. In this work, we introduce persistent analogs of topological complexity and its cohomological lower…

Algebraic Topology · Mathematics 2025-08-19 Facundo Mémoli , Ling Zhou

This article proposes a topological method that extracts hierarchical structures of various amorphous solids. The method is based on the persistence diagram (PD), a mathematical tool for capturing shapes of multiscale data. The input to the…

The objective of this study is to detect and quantify the periodic behavior of the signals using topological methods. We propose to use delay-coordinate embeddings as a tool to measure the periodicity of signals. Moreover, we use persistent…

Algebraic Topology · Mathematics 2014-02-21 Saba Emrani , Thanos Gentimis , Hamid Krim

We apply tools from topological data analysis to two mathematical models inspired by biological aggregations such as bird flocks, fish schools, and insect swarms. Our data consists of numerical simulation output from the models of Vicsek…

Quantitative Methods · Quantitative Biology 2018-11-21 Chad M. Topaz , Lori Ziegelmeier , Tom Halverson

Persistent homology provides a new approach for the topological simplification of big data via measuring the life time of intrinsic topological features in a filtration process and has found its success in scientific and engineering…

Biomolecules · Quantitative Biology 2014-12-09 Bao Wang , Guo-Wei Wei

Convection is a well-studied topic in fluid dynamics, yet it is less understood in the context of networks flows. Here, we incorporate techniques from topological data analysis (namely, persistent homology) to automate the detection and…

Dynamical Systems · Mathematics 2022-03-15 Minh Quang Le , Dane Taylor

Intersection homology is a topological invariant which detects finer information in a space than ordinary homology. Using ideas from classical simple homotopy theory, we construct local combinatorial transformations on simplicial complexes…

Algebraic Topology · Mathematics 2020-05-26 Markus Banagl , Tim Mäder , Filip Sadlo

Understanding genetic variation, e.g., through mutations, in organisms is crucial to unravel their effects on the environment and human health. A fundamental characterization can be obtained by solving the haplotype assembly problem, which…

Genomics · Quantitative Biology 2022-10-25 Hansheng Xue , Vaibhav Rajan , Yu Lin
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