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Persistent homology, a technique from computational topology, has recently shown strong empirical performance in the context of graph classification. Being able to capture long range graph properties via higher-order topological features,…

Machine Learning · Computer Science 2024-12-20 Rubén Ballester , Bastian Rieck

Computational topologists recently developed a method, called persistent homology to analyze data presented in terms of similarity or dissimilarity. Indeed, persistent homology studies the evolution of topological features in terms of a…

Quantitative Methods · Quantitative Biology 2017-08-01 Pavel Petrov , Stephen T Rush , Zhichun Zhai , Christine H Lee , Peter T Kim , Giseon Heo

Amorphous materials exhibit complex material proprteties with strongly nonlinear behaviors. Below a yield stress they behave as plastic solids, while they start to yield above a critical stress $\Sigma_c$. A key quantity controlling…

Biological Physics · Physics 2020-05-06 Marko Popović , Valentin Druelle , Natalie A. Dye , Frank Jülicher , Matthieu Wyart

In this paper, we study the stability of commonly used filtration functions in topological data analysis under small perturbations of the underlying nonrandom point cloud. Relying on these stability results, we then develop a test procedure…

Statistics Theory · Mathematics 2024-10-10 Johannes Krebs , Daniel Rademacher

The processes taking place inside the living cell are now understood to the point where predictive computational models can be used to gain detailed understanding of important biological phenomena. A key challenge is to extrapolate this…

Tissues and Organs · Quantitative Biology 2018-10-26 Stefan Engblom Daniel B. Wilson , Ruth E. Baker

Chromosomal crossovers play a crucial role in meiotic cell division, as they ensure proper chromosome segregation and increase genetic variability. Experiments have consistently revealed two key observations across species: (i) the number…

Biological Physics · Physics 2025-09-12 Marcel Ernst , Riccardo Rossetto , David Zwicker

Topologically ordered phases of matter display a number of unique characteristics, including ground states that can be interpreted as patterns of closed strings. In this paper, we consider the problem of detecting and distinguishing closed…

Statistical Mechanics · Physics 2022-09-16 Dan Sehayek , Roger G. Melko

We present a parallelizable algorithm for computing the persistent homology of a filtered chain complex. Our approach differs from the commonly used reduction algorithm by first computing persistence pairs within local chunks, then…

Algebraic Topology · Mathematics 2013-03-05 Ulrich Bauer , Michael Kerber , Jan Reininghaus

Persistent homology is a multiscale method for analyzing the shape of sets and functions from point cloud data arising from an unknown distribution supported on those sets. When the size of the sample is large, direct computation of the…

During development, highly ordered structures emerge as cells collectively coordinate with each other. While recent advances have clarified how individual cells process and respond to external signals, understanding collective cellular…

Biological Physics · Physics 2026-02-05 Ashutosh Tripathi , Jörn Dunkel , Dominic J. Skinner

A challenge in computational topology is to deal with large filtered geometric complexes built from point cloud data such as Vietoris-Rips filtrations. This has led to the development of schemes for parallel computation and compression…

Algebraic Topology · Mathematics 2022-05-04 Bradley J. Nelson

The ability to reroute and control flow is vital to the function of venation networks across a wide range of organisms. By modifying individual edges in these networks, either by adjusting edge conductances or creating and destroying edges,…

Soft Condensed Matter · Physics 2021-01-14 Jason W. Rocks , Andrea J. Liu , Eleni Katifori

In this paper, we consider topological featurizations of data defined over simplicial complexes, like images and labeled graphs, obtained by convolving this data with various filters before computing persistence. Viewing a convolution…

Algebraic Topology · Mathematics 2024-01-26 Elchanan Solomon , Paul Bendich

Quantitative analysis of the dynamics of tiny cellular and sub-cellular structures, known as particles, in time-lapse cell microscopy sequences requires the development of a reliable multi-target tracking method capable of tracking numerous…

Computer Vision and Pattern Recognition · Computer Science 2015-07-24 Seyed Hamid Rezatofighi , Stephen Gould , Ba Tuong Vo , Ba-Ngu Vo , Katarina Mele , Richard Hartley

Involved in mitotic condensation, interaction of transcriptional regulatory elements or isolation of structural domains, understanding loop formation is becoming a paradigm in the deciphering of chromatin architecture and its functional…

Quantitative Methods · Quantitative Biology 2024-09-17 Michaël Liefsoens , Timothy Földes , Maria Barbi

The study of phase transitions using data-driven approaches is challenging, especially when little prior knowledge of the system is available. Topological data analysis is an emerging framework for characterizing the shape of data and has…

Statistical Mechanics · Physics 2021-05-26 Quoc Hoan Tran , Mark Chen , Yoshihiko Hasegawa

In recent years, cosmic shear has emerged as a powerful tool to study the statistical distribution of matter in our Universe. Apart from the standard two-point correlation functions, several alternative methods like peak count statistics…

Cosmology and Nongalactic Astrophysics · Physics 2021-04-21 Sven Heydenreich , Benjamin Brück , Joachim Harnois-Déraps

Cell type (e.g. pluripotent cell, fibroblast) is the end result of many complex processes that unfold due to evolutionary, developmental, and transformational stimuli. A cell's phenotype and the discrete, a priori states that define various…

Quantitative Methods · Quantitative Biology 2013-02-05 Bradly Alicea

An asymptotic interface equation for directional solidification near the absolute stabiliy limit is extended by a nonlocal term describing a shear flow parallel to the interface. In the long-wave limit considered, the flow acts…

Condensed Matter · Physics 2009-11-07 Yannick Marietti , Jean-Marc Debierre , Thomas-Michael Bock , Klaus Kassner

Persistent homology tracks topological features across geometric scales, encoding birth and death of cycles as barcodes. We develop a complementary theory where the filtration parameter is algebraic precision rather than geometric scale.…

Algebraic Topology · Mathematics 2025-11-04 Robert Ghrist , Cassie Ding
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