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Molecular sorting is a fundamental process that allows eukaryotic cells to distill and concentrate specific chemical factors in appropriate cell membrane subregions, thus endowing them with different chemical identities and functional…
Inspired by numerous lab on a chip, biomedical and bioengineering applications such as cell sorting, focusing, trapping, and filtering of particles, manipulation of micron sized particle trajectories has been of significant interest in the…
Modern micromanipulation techniques typically involve trapping using electromagnetic, acoustic or flow fields that produce stresses on the trapped particles thereby precluding stress-free manipulations. Here, we show that by employing…
A pore-scale model is introduced for two-phase flow in dense packings of polydisperse spheres. The model is developed as a component of a more general hydromechanical coupling framework based on the discrete element method, which will be…
Particle flow processing is widely employed across various industrial applications and technologies. Due to the complex interactions between particles and fluids, designing effective devices for particle flow processing is challenging. In…
The behavior of particles driven through a narrow constriction is investigated in experiment and simulation. The system of particles adapts to the confining potentials and the interaction energies by a self-consistent arrangement of the…
Flow-based microfluidic biochips have attracted much atten- tion in the EDA community due to their miniaturized size and execution efficiency. Previous research, however, still follows the traditional computing model with a dedicated…
The dynamics of entrainment of finite-size heavy particles in a turbulent open channel flow over a smooth surface are analyzed. Three types of simulations, namely with freely moving, rotation-constrained, and spanwise-motion-constrained…
Eukaryotic cells maintain their inner order by a hectic process of distillation of molecular factors taking place on the surface of their lipid membranes. To understand the properties of this molecular sorting process, a physical model of…
In a seminal article, \citet[J. Fluid Mech., 174:441-465]{maxey87} presented a theoretical analysis showing that enhanced particle settling speeds in turbulence occur through the preferential sweeping mechanism, which depends on the…
Deterministic lateral displacement (DLD) devices separate micrometer-scale particles in solution based on their size using a laminar microfluidic flow in an array of obstacles. We investigate array geometries with rational row-shift…
Inertial microfluidic is able to focus and separate particles in microchannels based on the characteristic geometry and intrinsic hydrodynamic effect. Yet, the vertical position of suspended particles in the microchannel cannot be…
By approximating posterior distributions with weighted samples, particle filters (PFs) provide an efficient mechanism for solving non-linear sequential state estimation problems. While the effectiveness of particle filters has been…
Inertial focusing in curved microfluidic ducts exploits the interaction of drag force from the Dean flow with the inertial lift force to separate particles or cells laterally across the cross-section width according to their size.…
Particle-laden flows in helical channels are of interest for their applications in spiral particle separators used in the mining and mineral processing industries. In this paper, we extend the previous work of Lee, Stokes, Bertozzi (2013)…
Understanding particle transport and localisation in porous channels, especially at moderate Reynolds numbers, is relevant for many applications ranging from water reclamation to biological studies. Recently, researchers experimentally…
We present a new numerical model to simulate settling trajectories of discretized individual or a mixture of particles of different geometrical shapes in a quiescent fluid and their flow trajectories in a flowing fluid. Simulations unveiled…
This work proposes lossless and near-lossless compression algorithms for multi-channel biomedical signals. The algorithms are sequential and efficient, which makes them suitable for low-latency and low-power signal transmission…
The main motivation of this work is the quantitative prediction and description of particle manipulation (displacement across streamlines) in microfluidic flow. Much attention has been paid recently to placing particles in fast oscillatory…
We consider multiscale stochastic systems that are partially observed at discrete points of the slow time scale. We introduce a particle filter that takes advantage of the multiscale structure of the system to efficiently approximate the…