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The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC separation microfilters due to their simplicity and…

Cell Behavior · Quantitative Biology 2016-01-11 Mohammad Aghaamoo , Zhifeng Zhang , Xiaolin Chen , Jie Xu

Sub-visible particle analysis using flow imaging microscopy combined with deep learning has proven effective in identifying particle types, enabling the distinction of harmless components such as silicone oil from protein particles.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Utku Ozbulak , Michaela Cohrs , Hristo L. Svilenov , Joris Vankerschaver , Wesley De Neve

We consider fitting a bivariate spline regression model to data using a weighted least-squares cost function, with weights that sum to one to form a discrete probability distribution. By applying the principle of maximum entropy, the weight…

Methodology · Statistics 2025-08-05 Pierluigi Amodio , Luigi Brugnano , Felice Iavernaro

This article presents a high order conservative flux optimization (CFO) finite element method for the elliptic diffusion equations. The numerical scheme is based on the classical Galerkin finite element method enhanced by a flux…

Numerical Analysis · Mathematics 2019-11-13 Yujie Liu , Yue Feng , Ran Zhang

We combine theory, numerical calculations, and experiments to accurately predict the motion of anisotropic particles in shallow microfluidic channels, in which the particles are strongly confined in the vertical direction. We formulate an…

Soft Condensed Matter · Physics 2017-10-13 Bram Bet , Rumen Georgiev , William Uspal , Huyesin Burak Eral , René van Roij , Sela Samin

In fully-developed pressure-driven flow, the spreading of a dissolved solute is enhanced in the flow direction due to transverse velocity variations in a phenomenon now commonly referred to as Taylor-Aris dispersion. It is well understood…

Fluid Dynamics · Physics 2022-10-04 Garam Lee , Alan Luner , Jeremy Marzuola , Daniel M. Harris

Experimental studies of the variation of the mean square displacement (MSD) of a particle in a confined colloid suspension that exhibits density variations on the scale length of the particle diameter are not in agreement with the…

Soft Condensed Matter · Physics 2018-06-13 Molly Wolfson , Christopher Liepold , Binhua Lin , Stuart A. Rice

Contactless manipulation of small objects is essential for biomedical and chemical applications, such as cell analysis, assisted fertilisation, and precision chemistry. Established methods, including optical, acoustic, and magnetic…

Fluid Dynamics · Physics 2025-07-02 Lucas Amoudruz , Petr Karnakov , Petros Koumoutsakos

The time discrete scheme of characteristics type is especially effective for convection-dominated diffusion problems. The scheme has been used in various engineering areas with different approximations in spatial direction. The lowest-order…

Numerical Analysis · Mathematics 2022-04-28 W. Sun

In this work, we present a high-fidelity and efficient point-particle direct numerical simulation framework based on a multi-block overset curvilinear grid system, enabling large-scale Lagrangian particle tracking in complex geometries with…

Fluid Dynamics · Physics 2025-09-10 Taiyang Wang , Baoqing Meng , Baolin Tian , Yaomin Zhao

An algorithm for a family of self-starting high-order implicit time integration schemes with controllable numerical dissipation is proposed for both linear and nonlinear transient problems. This work builds on the previous works of the…

Numerical Analysis · Mathematics 2024-09-23 Daniel O'Shea , Xiaoran Zhang , Shayan Mohammadian , Chongmin Song

Dissipative particle dynamics (DPD) belongs to a class of models and computational algorithms developed to address mesoscale problems in complex fluids and soft matter in general. It is based on the notion of particles that represent…

Statistical Mechanics · Physics 2017-05-24 Pep Español , Patrick B Warren

Particle tracking is common in many biophysical, ecological, and micro-fluidic applications. Reliable tracking information is heavily dependent on of the system under study and algorithms that correctly determines particle position between…

Computer Vision and Pattern Recognition · Computer Science 2016-05-12 Alvaro Rodriguez , Hanqing Zhang , Krister Wiklund , Tomas Brodin , Jonatan Klaminder , Patrik Andersson , Magnus Andersson

Sorting cells based on their intrinsic properties is a highly desirable objective, since changes in cell deformability are often associated with various stress conditions and diseases. Deterministic lateral displacement (DLD) devices offer…

Fluid Dynamics · Physics 2024-06-03 Zunmin Zhang , Wei Chien , Ewan Henry , Dmitry A. Fedosov , Gerhard Gompper

Chemical bioreactions play a significant role in many of the microfluidic devices, and their applications in biomedical science have seen substantial growth. Given that effective mixing is vital for initiating biochemical reactions in many…

Fluid Dynamics · Physics 2024-02-13 Ali Kheirkhah Barzoki

Up to date, inertial migration of particles in microflows has demonstrated a great potential for a wide range of applications. In particular, this phenomenon is used to achieve particle separation or sorting in a suspension. Recent works…

Soft Condensed Matter · Physics 2019-07-29 Tohme Tohme , Yanfeng Gao , Pascale Magaud , Lucien Baldas , Christine Lafforgue , Stéphane Colin

We study shortest-path routing in large weighted, undirected graphs, where expanding search frontiers raise time and memory costs for exact solvers. We propose \emph{SPHERE}, a query-aware partitioning heuristic that adaptively splits the…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-16 Robert Fabian Lindermann , Paul-Niklas Ken Kandora , Simon Caspar Zeller , Adrian Asmund Fessler , Steffen Rebennack

We present a new algorithm to optimize distributions defined implicitly by parameterized stochastic diffusions. Doing so allows us to modify the outcome distribution of sampling processes by optimizing over their parameters. We introduce a…

Effective stormwater treatment infrastructures are crucial for mitigating the adverse effects of runoff on urban water quality. However, designing cost-effective treatment systems can be challenging due to complex turbulent flow dynamics.…

Fluid Dynamics · Physics 2024-07-24 Haochen Li

Numerical simulations including magnetic fields have become important in many fields of astrophysics. Evolution of magnetic fields by the constrained transport algorithm preserves magnetic divergence to machine precision, and thus…

Astrophysics · Physics 2009-11-13 Jason Maron , Mordecai-Mark Mac Low , Jeffrey Oishi
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