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Biological mixtures, such as the cellular cytoplasm, are composed of a large number of different components. From this heterogeneity, ordered mesoscopic structures emerge, such as liquid phases with controlled composition. These structures…

Biological Physics · Physics 2024-12-03 Rodrigo Braz Teixeira , Giorgio Carugno , Izaak Neri , Pablo Sartori

Phase diagrams are an invaluable tool for material synthesis and provide information on the phases of the material at any given thermodynamic condition. Conventional phase diagram generation involves experimentation to provide an initial…

Understanding how multi-component liquid mixtures undergo phase separation is central to elucidating biophysical organization in the cell. Here, combining analytical and numerical results, we characterise the dynamics of mixtures with…

Soft Condensed Matter · Physics 2026-02-06 Giacomo Bartolucci , Fabrizio Olmeda

A diffuse-interface model for microstructure with an arbitrary number of components and phases was developed from basic thermodynamic and kinetic principles and formalized within a variational framework. The model includes a composition…

Materials Science · Physics 2011-07-28 Daniel A. Cogswell , W. Craig Carter

This paper extends our earlier studies of free energy functions of density and crystalline order parameters for models of supercooled water, which allows us to examine the possibility of two distinct metastable liquid phases [J. Chem. Phys.…

Statistical Mechanics · Physics 2015-06-15 David T. Limmer , David Chandler

For two-dimensional many-particle systems first-order, second-order, single step continuous, as well as two-step continuous (KTHNY-like) melting transitions have been found in previous studies. Recent computer simulations, using particle…

Materials Science · Physics 2014-06-23 Aranka Derzsi , Kovács Anikó Zsuzsa , Zoltán Donkó , Peter Hartmann

In active systems, whose constituents have non-equilibrium dynamics at local level, fluid-fluid phase separation is widely observed. Examples include the formation of membraneless organelles within cells; the clustering of self-propelled…

Soft Condensed Matter · Physics 2025-07-11 M. E. Cates , C. Nardini

Biological mixtures such as the cytosol may consist of thousands of distinct components. There is now a substantial body of evidence showing that, under physiological conditions, intracellular mixtures can phase separate into spatially…

Soft Condensed Matter · Physics 2017-03-06 William M. Jacobs , Daan Frenkel

Liquid mixtures of many interacting components often exhibit numerous coexisting types of droplets. An exciting example is the cytosol of biological cells, where diverse droplets, called condensates, are essential for cellular function.…

Soft Condensed Matter · Physics 2025-05-28 Yicheng Qiang , Chengjie Luo , David Zwicker

Much work has been devoted to analysing thermodynamic models for solid dispersions with a view to identifying regions in the phase diagram where amorphous phase separation or drug recrystallization can occur. However, detailed partial…

Soft Condensed Matter · Physics 2020-06-26 Martin Meere , Giuseppe Pontrelli , Sean McGinty

Phase separation is a fairly common physical phenomenon with examples including the formation of water droplets from humid air (fog, rain), the separation of a crystalline structure from an isotropic material such as a liquid or even the…

Probability · Mathematics 2007-05-23 Ágoston Pisztora

The work discusses specifics of phase transitions for metastable states of substances. The objects of condensed media physics are primarily equilibrium states of substances with metastable phases viewed as an exception, while the…

Materials Science · Physics 2009-11-11 V. V. Brazhkin

We investigate the phase behavior of a single-component system in 3 dimensions with spherically-symmetric, pairwise-additive, soft-core interactions with an attractive well at a long distance, a repulsive soft-core shoulder at an…

Soft Condensed Matter · Physics 2009-11-07 G. Franzese , G. Malescio , A. Skibinsky , S. V. Buldyrev , H. E. Stanley

We present a formalism to describe slowly decaying systems in the context of finite Markov chains obeying detailed balance. We show that phase space can be partitioned into approximately decoupled regions, in which one may introduce…

Statistical Mechanics · Physics 2007-05-23 Hernan Larralde , Francois Leyvraz , David P. Sanders

Complex systems are often characterized by the interplay of multiple interconnected dynamical processes operating across a range of temporal scales. This phenomenon is widespread in both biological and artificial scenarios, making it…

Statistical Mechanics · Physics 2025-09-08 Giorgio Nicoletti , Daniel M. Busiello

When liquids are cooled sufficiently rapidly below their melting temperature, they may bypass crystalization and, instead, enter a long-lived metastable supercooled state that has long been the focus of intense research. Although they…

Statistical Mechanics · Physics 2023-12-05 Zohar Nussinov

Materials with nanoscale phase separation are considered. These materials are formed by a mixture of several phases, so that inside one phase there exist nanosize inclusions of other phases, with random shapes and random spatial locations.…

Mesoscale and Nanoscale Physics · Physics 2014-03-31 V. I. Yukalov , E. P. Yukalova

We present theory and simulation of simultaneous chemical demixing and phase ordering in a polymer-liquid crystal mixture in conditions where isotropic-isotropic phase separation is metastable with respect to isotropic-nematic phase…

Soft Condensed Matter · Physics 2015-06-17 Ezequiel R. Soulé , Alejandro D. Rey

Liquid-liquid phase separation has recently emerged as an important topic in the context of cellular organization. Within this context, there are multiple poorly understood features; for instance hints of critical behavior in the plasma…

Statistical Mechanics · Physics 2024-06-25 Felix Herrmann , Burkhard Dünweg , Martin Girard

When studying a metastable dynamical system, a prime concern is how to decompose the phase space into a set of metastable states. Unfortunately, the metastable state decomposition based on simulation or experimental data is still a…

Machine Learning · Computer Science 2015-01-05 Hao Wu
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