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The phase behavior is investigated for systems composed of a large number of macromolecular components N, with N greater or equal to 2. Liquid-liquid phase separation is modelled using a virial expansion up to the second order of the…

Soft Condensed Matter · Physics 2024-05-29 Arjen Bot , Erik van der Linden , Paul Venema

Simulating transition dynamics between metastable states is a fundamental challenge in dynamical systems and stochastic processes with wide real-world applications in understanding protein folding, chemical reactions and neural activities.…

Machine Learning · Computer Science 2024-10-22 Haibo Wang , Yuxuan Qiu , Yanze Wang , Rob Brekelmans , Yuanqi Du

Due to nonuniform aggregation in liquid state, from the thermodynamic point of view any glass-forming liquid in the vicinity of the liquid-to-solid phase transition temperature, irrespective of its actual chemical composition, shall be…

Disordered Systems and Neural Networks · Physics 2021-03-18 Vladimir Belostotsky

Stochastic systems often exhibit multiple viable metastable states that are long-lived. Over very long timescales, fluctuations may push the system to transition between them, drastically changing its macroscopic configuration. In realistic…

Statistical Mechanics · Physics 2023-04-14 Tobias Grafke , Alessandro Laio

It is known that purely repulsive self-propelled colloids can undergo bulk liquid-vapor phase separation. In experiments and large scale simulations, however, more complex steady states are also seen, comprising a dynamic population of…

Soft Condensed Matter · Physics 2018-10-03 Elsen Tjhung , Cesare Nardini , Michael E. Cates

The recent paper cited above claims that a molecular simulation of one specific model of supercooled water establishes a stable interface separating two metastable liquid phases, which would imply the existence of metastable two-liquid…

Statistical Mechanics · Physics 2014-08-21 David Chandler

In the framework of time series analysis with recurrence networks, we introduce a self-adaptive method that determines the elusive recurrence threshold and identifies metastable states in complex real-world time series. As initial step, we…

Data Analysis, Statistics and Probability · Physics 2014-10-22 Iliusi Vega , Christof Schütte , Tim O. F. Conrad

The kinetics of the multicomponent condensation after the instantaneous creation of the metastable state is described analytically. Manydimensional problem is reduced to the one-dimensional case. All the main characteristics of the process…

Condensed Matter · Physics 2007-05-23 V. Kurasov

Theory and simulations of simultaneous chemical demixing and phase ordering are performed for a mixed order parameter system with an isotropic-isotropic (I-I) phase separation that is metastable with respect to an isotropic-nematic (I-N)…

Soft Condensed Matter · Physics 2015-06-17 Ezequiel R. Soule , Cyrille Lavigne , Linda Reven , Alejandro D. Rey

Phase separation plays an role in determining the self-assembly of biological and soft-matter systems. In biological systems, liquid-liquid phase separation inside a cell leads to the formation of various macromolecular aggregates. The…

Soft Condensed Matter · Physics 2024-03-26 Tanmay Biswas , Gerhard Kahl , Gaurav P. Shrivastav

Phase separation in the Hubbard model is investigated with the dynamical cluster approximation. We find that it is present in the paramagnetic solution for values of filling smaller than one and at finite temperature when a positive…

Strongly Correlated Electrons · Physics 2007-05-23 A. Macridin , M. Jarrell , Th. Maier

This paper continues the study of metastable behaviour in disordered mean field models initiated in [2], [3]. We consider the generalized Hopfield model with finitely many independent patterns $\xi_1,...,\xi_p$ where the patterns have…

Probability · Mathematics 2009-04-27 Mykhaylo Shkolnikov

Metastable self-organized electronic states in quantum materials are of fundamental importance, displaying emergent dynamical properties that may be used in new generations of sensors and memory devices. Such states are typically formed…

Proteins and nucleic acids can spontaneously self-assemble into membraneless droplet-like compartments, both in vitro and in vivo. A key component of these droplets are multi-valent proteins that possess several adhesive domains with…

Biomolecules · Quantitative Biology 2020-01-10 Srivastav Ranganathan , Eugene Shakhnovich

Multi-stable mechanical structures find cutting-edge applications across various domains due to their reconfigurability, which offers innovative possibilities for engineering and technology advancements. This study explores the emergence of…

Applied Physics · Physics 2024-02-13 Zhen Wang , Feiyang Sun , Xiaodong Xu , Xin Li , Chuanqing Chen , Minghui Lu

The central question that we address is: How can structured information be stored in a hierarchical Hopfield model involving hidden layers? To this end, we develop a formalism of strokes and concepts that allows us to appropriately…

Probability · Mathematics 2026-04-29 Markus Heydenreich , Christian Hirsch , Matthias Löwe

In this work we identify and investigate a novel bifurcation in conserved systems. This secondary bifurcation stops active phase separation in its nonlinear regime. It is then either replaced by an extended, system-filling, spatially…

Pattern Formation and Solitons · Physics 2022-02-22 Frederik J. Thomsen , Lisa Rapp , Fabian Bergmann , Walter Zimmermann

Metadynamics is a commonly used and successful enhanced sampling method. By the introduction of a history dependent bias which depends on a restricted number of collective variables(CVs) it can explore complex free energy surfaces…

Statistical Mechanics · Physics 2013-12-06 Pratyush Tiwary , Michele Parrinello

To maintain homeostasis, living cells process information with networks of interacting molecules. Traditional models for cellular information processing have focused on networks of chemical reactions between molecules. Here, we describe how…

Biological Physics · Physics 2025-08-01 Arvind Murugan , David Zwicker , Charlotta Lorenz , Eric R. Dufresne

Recent studies have shown that metaplastic synapses can retain information longer than simple binary synapses and are beneficial for continual learning. In this paper, we explore the multistate metaplastic synapse characteristics in the…

Neural and Evolutionary Computing · Computer Science 2020-03-27 Fatima Tuz Zohora , Abdullah M. Zyarah , Nicholas Soures , Dhireesha Kudithipudi