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We derive an asymptotically consistent morphoelastic shell model to describe the finite deformations of biological tissues using the variational asymptotical method. Biological materials may exhibit remarkable compressibility when under…

Soft Condensed Matter · Physics 2024-07-23 Xiang Yu , Xiaoyi Chen

The generation of anisotropic shapes occurs during morphogenesis of almost all organisms. With the recent renewal of the interest in mechanical aspects of morphogenesis, it has become clear that mechanics contributes to anisotropic forms in…

Cell Behavior · Quantitative Biology 2018-04-19 Jean-Daniel Julien , Arezki Boudaoud

The fields of mechanobiology and biomechanics are expanding our understanding of the complex behavior of soft biological tissues across multiple scales. Given the intricate connection between tissue microstructure and its macroscale…

Soft Condensed Matter · Physics 2025-09-03 Sara Cardona , Mathias Peirlinck , Behrooz Fereidoonnezhad

Machines enabled the Industrial Revolution and are central to modern technological progress: A machine's parts transmit forces, motion, and energy to one another in a predetermined manner. Today's engineering frontier, building artificial…

Soft Condensed Matter · Physics 2021-11-18 A. Aubret , Q. Martinet , J. Palacci

The sensitivity of heterogeneous energetic (HE) materials (propellants, explosives, and pyrotechnics) is critically dependent on their microstructure. Initiation of chemical reactions occurs at hot spots due to energy localization at sites…

Materials Science · Physics 2023-05-12 Sehyun Chun , Sidhartha Roy , Yen Thi Nguyen , Joseph B. Choi , H. S. Udaykumar , Stephen S. Baek

We introduce Generator Matching, a modality-agnostic framework for generative modeling using arbitrary Markov processes. Generators characterize the infinitesimal evolution of a Markov process, which we leverage for generative modeling in a…

Machine Learning · Computer Science 2025-02-28 Peter Holderrieth , Marton Havasi , Jason Yim , Neta Shaul , Itai Gat , Tommi Jaakkola , Brian Karrer , Ricky T. Q. Chen , Yaron Lipman

Many biological networks grow by elongation of filaments that can branch and fuse -- typical examples include fungal mycelium or slime mold. These networks must simultaneously perform multiple tasks such as transport, exploration, and…

Adaptation and Self-Organizing Systems · Physics 2026-01-08 Maxime Lucas , Corentin Bisot , Giovanni Petri , Stéphane Declerck , Timoteo Carletti

When used in bulk applications, mechanical metamaterials set forth a multiscale problem with many orders of magnitude in scale separation between the micro and macro scales. However, mechanical metamaterials fall outside conventional…

Analysis of PDEs · Mathematics 2025-01-28 M. P. Ariza , S. Conti , M. Ortiz

Dynamic homogenization aims at describing the macroscopic characteristics of wave propagation in microstructured systems. Using a simple method, we derive frequency-dependent homogenized parameters that reproduce the exact dispersion…

Applied Physics · Physics 2018-08-01 René Pernas-Salomón , Gal Shmuel

The spongy mesophyll is a complex, porous tissue found in plant leaves that enables carbon capture and provides mechanical stability. Unlike many other biological tissues, which remain confluent throughout development, the spongy mesophyll…

Recent advances in generative modeling, namely Diffusion models, have revolutionized generative modeling, enabling high-quality image generation tailored to user needs. This paper proposes a framework for the generative design of structural…

Spinodal decomposition process in the system of immiscible PbTe/CdTe compounds is analyzed as an example of a self-organizing structure. The immiscibility of the constituents leads to the observed morphological transformations like…

Molecular conformer generation is a fundamental task in computational chemistry. Several machine learning approaches have been developed, but none have outperformed state-of-the-art cheminformatics methods. We propose torsional diffusion, a…

Chemical Physics · Physics 2023-03-02 Bowen Jing , Gabriele Corso , Jeffrey Chang , Regina Barzilay , Tommi Jaakkola

A model to describe the arising of new structures in an initial homogeneous biological system is proposed. The essay is motivated by the intention to work on a non-equilibrium situation grouping together several mechanisms and processes as:…

Biological Physics · Physics 2007-05-23 P. C. T. Dajello , P. R. Hauser

During growth, tissue expands and deforms. Given its elastic properties, stresses emerge in an expanding and deforming tissue. Cell rearrangements can dissipate these stresses and numerous experiments confirm the viscoelastic properties of…

Tissues and Organs · Quantitative Biology 2017-10-20 M. D. Peters , D. Iber

It is stated in the main in essence new approach to mechanics of the stressed state of the solid body from statistically isotropic material and the homogeneous liquid dynamics. The approach essence is in the detected property of the…

Fluid Dynamics · Physics 2008-09-25 S. L. Arsenjev

We demonstrate directional dependence of the self-modification of internal mesospin textures in magnetic metamaterials, arising from the coupling of the atomic- and mesoscopic length-scales. Dressing the mesospins in different directions…

Mesoscale and Nanoscale Physics · Physics 2022-05-09 Nanny Strandqvist , Björn Erik Skovdal , Merlin Pohlit , Henry Stopfel , Vassilios Kapaklis , Björgvin Hjörvarsson

The applicability of computational and dynamical systems models to organisms is scrutinized, using examples from developmental biology and cognition. Developmental morphogenesis is dependent on the inherent material properties of developing…

Neurons and Cognition · Quantitative Biology 2023-10-24 Stuart A. Newman

Protein structure prediction and folding are fundamental to understanding biology, with recent deep learning advances reshaping the field. Diffusion-based generative models have revolutionized protein design, enabling the creation of novel…

Machine Learning · Computer Science 2025-10-01 Yogesh Verma , Markus Heinonen , Vikas Garg

During development, epithelial tissues undergo extensive morphogenesis based on coordinated changes of cell shape and position over time. Continuum mechanics describes tissue mechanical state and shape changes in terms of strain and stress.…

Cell Behavior · Quantitative Biology 2012-05-14 Isabelle Bonnet , Philippe Marcq , Floris Bosveld , Luc Fetler , Yohanns Bellaiche , Francois Graner
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