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The growth of plants is a hydromechanical phenomenon in which cells enlarge by absorbing water, while their walls expand and remodel under turgor-induced tension. In multicellular tissues, where cells are mechanically interconnected,…

Biological Physics · Physics 2025-09-09 Hadrien Oliveri , Ibrahim Cheddadi

The paper presents a topology optimization approach that designs an optimal structure, called a self-supporting structure, which is ready to be fabricated via additive manufacturing without the usage of additional support structures. Such…

Computational Engineering, Finance, and Science · Computer Science 2017-08-25 Dengyang Zhao , Ming Li , Yusheng Liu

Connecting cell behavior to tissue shape and mechanics is a key challenge in the physics of morphogenesis. Cytoskeletal turnover precludes a fixed reference state, and tensions are actively generated independently of strain; so conventional…

Soft Condensed Matter · Physics 2026-05-28 Nikolas H. Claussen , Fridtjof Brauns , Boris I. Shraiman

Plant morphogenesis relies on dynamic growth deformations at the cell and tissue scales driven by osmotic fluxes. A mechanistic understanding of this phenomenon demands a physical framework that integrates cell imbibition, tissue mechanics,…

Biological Physics · Physics 2025-12-08 Hadrien Oliveri , Christophe Godin , Ibrahim Cheddadi

We propose a predictive model for the mechanical behavior of biodegradable polymers of interest for biomedical applications. Starting from a detailed description of the network behavior of the copolymer material, taking care of bonds…

Soft Condensed Matter · Physics 2022-06-02 Gennaro Vitucci , Domenico De Tommasi , Giuseppe Puglisi , Francesco Trentadue

Topological metamaterials have invaded the mechanical world, demonstrating acoustic cloaking and waveguiding at finite frequencies and variable, tunable elastic response at zero frequency. Zero frequency topological states have previously…

Soft Condensed Matter · Physics 2018-12-05 Adrien Saremi , D. Zeb Rocklin

At the interface between two distinct materials desirable properties, such as superconductivity, can be greatly enhanced, or entirely new functionalities may emerge. Similar to in artificially engineered heterostructures, clean functional…

We study the dynamics of proliferating cell collectives whose microscopic constituents' growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a growing collective show the emergence of concentric-ring…

Biological Physics · Physics 2024-05-17 Scott Weady , Bryce Palmer , Adam Lamson , Taeyoon Kim , Reza Farhadifar , Michael J. Shelley

Designing metal-organic frameworks (MOFs) with novel chemistries is a longstanding challenge due to their large combinatorial space and complex 3D arrangements of the building blocks. While recent deep generative models have enabled…

Biomolecules · Quantitative Biology 2026-02-05 Nayoung Kim , Seongsu Kim , Sungsoo Ahn

A micromorphic computational homogenization framework has recently been developed to deal with materials showing long-range correlated interactions, i.e. displaying patterning modes. Typical examples of such materials are elastomeric…

Soft Condensed Matter · Physics 2024-06-21 S. Maraghechi , O. Rokoš , R. H. J. Peerlings , M. G. D. Geers , J. P. M. Hoefnagels

Self-assembly is the autonomous organization of components into patterns or structures: an essential ingredient of biology and a desired route to complex organization. At equilibrium, the structure is encoded through specific interactions,…

Soft Condensed Matter · Physics 2018-10-03 Antoine Aubret , Mena Youssef , Stefano Sacanna , Jérémie Palacci

Mechanical metamaterials are architected manmade materials that allow for unique behaviors not observed in nature, making them promising candidates for a wide range of applications. Existing metamaterials lack tunability as their properties…

Architected materials can achieve enhanced properties compared to their plain counterparts. Specific architecting serves as a powerful design lever to achieve targeted behavior without changing the base material. Thus, the connection…

Materials Science · Physics 2023-02-14 Andrew J. Lew , Kai Jin , Markus J. Buehler

The concept of metamaterials emerged in years 2000 with the achievement of artificial structures enabling non conventional propagation of electromagnetic waves, such as negative phase velocity of negative refraction. The electromagnetic…

We present a two-scale topology optimization framework for the design of macroscopic bodies with an optimized elastic response, which is achieved by means of a spatially-variant cellular architecture on the microscale. The chosen spinodoid…

Computational Engineering, Finance, and Science · Computer Science 2021-05-21 Li Zheng , Siddhant Kumar , Dennis M. Kochmann

Morphogenesis is central to biology but remains largely unexplored in chemistry. Reaction-diffusion (RD) mechanisms are, however, essential to understand how shape emerges in the living world. While numerical methods confirm the incredible…

Pattern Formation and Solitons · Physics 2014-07-17 Anton S. Zadorin , Yannick Rondelez , Jean-Christophe Galas , André Estevez-Torres

Morphogens are secreted signaling molecules that mediate tissue patterning and growth of embryonic tissues. They are secreted in a localized region and spread through the tissue to form a graded concentration profile. We present a…

A key challenge in metasurface design is the development of algorithms that can effectively and efficiently produce high performance devices. Design methods based on iterative optimization can push the performance limits of metasurfaces,…

Generative machine learning models have revolutionized material discovery by capturing complex structure-property relationships, yet extending these approaches to the inverse design of three-dimensional metamaterials remains limited by…

Computational Engineering, Finance, and Science · Computer Science 2026-04-27 Li Zheng , Siddhant Kumar , Dennis M. Kochmann

Mechanical metamaterials feature engineered microstructures designed to exhibit exotic, and often counter-intuitive, effective behaviour. Such a behaviour is often achieved through instability-induced transformations of the underlying…

Computational Engineering, Finance, and Science · Computer Science 2020-09-04 S. E. H. M. van Bree , O. Rokoš , R. H. J. Peerlings , M. Doškář , M. G. D. Geers