Related papers: Mapping of discrete range modulated proton radiogr…
Proton radiotherapy promises accurate dose delivery to a tumor and minimal dose deposition to all other tissues. However, in practice the planned dose distribution may not conform to the actual one due to noisy data and different types of…
Technical Note describing studies, in 2011, of time resolved diode dosimetry in an anthropomorphic phantom at the Francis H. Burr Proton Therapy Center, Massachusetts General Hospital, Boston, MA. This technique measures the water…
Purpose: To demonstrate a proton imaging system based on well-established fast scintillator technology to achieve high performance with low cost and complexity, with the potential of a straightforward translation into clinical use. Methods:…
Verification of patient specific proton stopping powers obtained in the patient treatment position can be used to reduce the distal margins needed in particle beam planning. Proton radiography can be used as a pre-treatment instrument to…
Purpose: Multiple Coulomb scattering (MCS) poses a challenge in proton CT (pCT) image reconstruction. The assumption of straight paths is replaced with Bayesian models of the most likely path (MLP). Current MLP-based pCT reconstruction…
Accurate dose calculation is vitally important for proton therapy. Pencil beam (PB) model-based dose calculation is fast but inaccurate due to the approximation when dealing with inhomogeneities. Monte Carlo (MC) dose calculation is the…
Northern Illinois University in collaboration with Fermi National Accelerator Laboratory (FNAL) and Delhi University has been designing and building a proton CT scanner for applications in proton treatment planning. The Phase II proton CT…
Purpose: Dual-energy CT (DECT) has been used to derive relative stopping power (RSP) map by obtaining the energy dependence of photon interactions. The DECT-derived RSP maps could potentially be compromised by image noise levels and the…
Proton Computed Tomography (pCT) provides a promising solution to enhance the accuracy of Relative Stopping Power (RSP) required for proton therapy planning. This research introduces a novel high-granularity pCT architecture that…
We have determined the depth-dose curve, the penetration range, and the water equivalent ratio (WER), for proton beams of clinical energies in cortical bone, by means of a detailed and accurate simulation that combines molecular dynamics…
Particle physics simulations are the cornerstone of nuclear engineering applications. Among them radiotherapy (RT) is crucial for society, with 50% of cancer patients receiving radiation treatments. For the most precise targeting of tumors,…
Contouring of the target volume and Organs-At-Risk (OARs) is a crucial step in radiotherapy treatment planning. In an adaptive radiotherapy setting, updated contours need to be generated based on daily imaging. In this work, we leverage…
The Most Likely Path formalism (MLP) is widely established as the most statistically precise method for proton path reconstruction in proton computed tomography (pCT). However, while this method accounts for small-angle Multiple Coulomb…
Objective: To develop and validate an independent Monet Carlo dose calculation engine to support for software verification of treatment planning systems and quality assurance workflow. Method: GATE Monte Carlo toolkit was employed to…
The major advantage of proton therapy over conventional radiotherapy is the dose deposition pattern, enabling precise coverage of the tumour volume while sparing nearby healthy tissues. However, accurate control of the proton beam range…
$Objective$. Obtaining the intrinsic dose distributions in particle therapy is a challenging problem that needs to be addressed by imaging algorithms to take advantage of secondary particle detectors. In this work, we investigate the…
For the in vivo range verification in proton therapy, it has been tried to measure the spatial distribution of the prompt gammas generated by the proton-induced interactions with the close relationship with the proton dose distribution.…
Accurate dose calculation on cone beam computed tomography (CBCT) images is essential for modern proton treatment planning workflows, particularly when accounting for inter-fractional anatomical changes in adaptive treatment scenarios.…
A novel dose calculation approach was designed based on the application of LSTM network that processes the 3D patient/phantom geometry as a sequence of 2D computed tomography input slices yielding a corresponding sequence of 2D slices that…
Objective. Prompt-gamma imaging encompasses several approaches for online monitoring of beam range or deposited dose distribution in proton therapy. We test one of the imaging techniques - a coded mask approach - both experimentally and via…