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Computed Tomography (CT) using synchrotron radiation is a powerful technique that, compared to lab-CT techniques, boosts high spatial and temporal resolution while also providing access to a range of contrast-formation mechanisms. The…

Image and Video Processing · Electrical Eng. & Systems 2025-01-20 Jiayang Shi , Daniel M. Pelt , K. Joost Batenburg

Knowledge of the mass composition of ultra-high-energy cosmic rays is crucial to understanding their origins; however, current approaches have limited event-by-event resolution. With fluorescence telescope measurements of the longitudinal…

High Energy Astrophysical Phenomena · Physics 2026-04-10 Zhuoyi Wang , Eric Mayotte , Sonja Mayotte , Nathan Woo , Julia Burton-Heibges , Nicolas San Martin , Cailyn Smith

In this work, we report on the advantageous aspects of the i-TED Compton imager for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that…

Purpose: A promising approach to enable FLASH conformal proton therapy is to passively degrade a single energy layer using a patient-specific range modulator. We propose an innovative method to directly optimize the geometrical…

Medical Physics · Physics 2023-03-16 Sylvain Deffet , Kevin Souris , Edmond Sterpin

The purpose of this study was to investigate the feasibility of extracting proton beams with two distinct energies within a single synchrotron cycle. The energy difference between the beams should be sufficient to use one beam as a range…

Accelerator Physics · Physics 2025-06-25 Alexander A. Pryanichnikov , Dmitry Shwartz , Jon Feldmand , Joao Seco , Maria Francesca Spadea

Deep learning-based automated contouring and treatment planning has been proven to improve the efficiency and accuracy of radiotherapy. However, conventional radiotherapy treatment planning process has the automated contouring and treatment…

Medical Physics · Physics 2024-12-02 Sangwook Kim , Aly Khalifa , Thomas G. Purdie , Chris McIntosh

Tissue and water equivalence of some phantom materials originally developed for conventional radiation therapy was investigated on the ITEP medical proton beam facility. The proton CSDA range in three variants of Plastic Water, lung,…

Dose verification based on proton-induced positron emitters is a promising quality assurance tool and may leverage the strength of artificial intelligence. To move a step closer towards practical application, the sensitivity analysis of two…

Medical Physics · Physics 2022-12-23 Shixiong Yu , Yuxiang Liu , Zongsheng Hu , Haozhao Zhang , Pengyu Qi , Hao Peng

The use of CT imaging is important for screening, diagnosis, therapy planning, and prognosis of lung cancers. Unfortunately, due to differences in imaging protocols and scanner models, CT images acquired by different means may show large…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Md Shifatul Ahsan Apurba , Md Selim , Jin Chen

We present an efficient approach for generating highly accurate molecular potential energy surfaces (PESs) using self-correcting, kernel ridge regression (KRR) based machine learning (ML). We introduce structure-based sampling to…

Chemical Physics · Physics 2018-08-20 Pavlo O. Dral , Alec Owens , Sergei N. Yurchenko , Walter Thiel

Recent research has highlighted the utility of Planar Parallax Geometry in monocular depth estimation. However, its potential has yet to be fully realized because networks rely heavily on appearance for depth prediction. Our in-depth…

Computer Vision and Pattern Recognition · Computer Science 2023-11-29 Haoqian Liang , Zhichao Li , Ya Yang , Naiyan Wang

We propose to develop deep learning models that can predict Pareto optimal dose distributions by using any given set of beam angles, along with patient anatomy, as input to train the deep neural networks. We implement and compare two deep…

Medical Physics · Physics 2021-01-27 Gyanendra Bohara , Azar Sadeghnejad Barkousaraie , Steve Jiang , Dan Nguyen

Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of planning objectives are involved. Deep reinforcement learning (DRL) has recently…

Quantitative Methods · Quantitative Biology 2024-09-19 Qingqing Wang , Chang Chang

Precise sensing and control of spatial mode content is essential for the performance of precision optical systems, particularly interferometric gravitational-wave detectors, where misalignment and mode mismatch can lead to significant…

Instrumentation and Methods for Astrophysics · Physics 2026-03-31 Liu Tao , Eleonora Capocasa , Yuhang Zhao , Jacques Ding , Isander Ahrend , Matteo Barsuglia

Delineation of tumors and organs-at-risk permits detecting and correcting changes in the patients' anatomy throughout the treatment, making it a core step of adaptive proton therapy (APT). Although AI-based auto-contouring technologies have…

Proton radiography combined with X-ray computed tomography (CT) has been proposed to obtain a patient-specific calibration curve and reduce range uncertainties in cancer treatment with charged particles. The main aim of this study was to…

We propose a fast beam orientation selection method, based on deep neural networks (DNN), capable of developing a plan comparable to those by the state-of-the-art column generation method. The novelty of Our model lies in its supervised…

Medical Physics · Physics 2019-12-23 Azar Sadeghnejad Barkousaraie , Olalekan Ogunmolu , Steve Jiang , Dan Nguyen

Purpose: To propose a wave-encoded model-based deep learning (wave-MoDL) strategy for highly accelerated 3D imaging and joint multi-contrast image reconstruction, and further extend this to enable rapid quantitative imaging using an…

Image and Video Processing · Electrical Eng. & Systems 2022-02-08 Jaejin Cho , Borjan Gagoski , Taehyung Kim , Qiyuan Tian , Stephen Robert Frost , Itthi Chatnuntawech , Berkin Bilgic

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…

Medical Physics · Physics 2018-12-03 Dan Nguyen , Troy Long , Xun Jia , Weiguo Lu , Xuejun Gu , Zohaib Iqbal , Steve Jiang

Proton therapy is a cancer treatment technique currently in growth worldwide. It offers advantages with respect to conventional X-ray and $\gamma$-ray radiotherapy, in particular, a better control of the dose deposition allowing to reach a…