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Large language models (LLMs) hold promise for transforming healthcare, from streamlining administrative and clinical workflows to enriching patient engagement and advancing clinical decision-making. However, their successful integration…

Computers and Society · Computer Science 2025-04-04 Mohammed Al-Garadi , Tushar Mungle , Abdulaziz Ahmed , Abeed Sarker , Zhuqi Miao , Michael E. Matheny

Large Language Models (LLMs) are often proposed as tools to streamline clinical documentation, a task viewed as both high-volume and low-risk. However, even seemingly straightforward applications of LLMs raise complex sociotechnical…

Human-Computer Interaction · Computer Science 2025-09-05 Kristina L. Kupferschmidt , Kieran O'Doherty , Joshua A. Skorburg

Large Language Models (LLMs) have emerged as highly capable systems and are increasingly being integrated into various uses. However, the rapid pace of their deployment has outpaced a comprehensive understanding of their internal mechanisms…

Computation and Language · Computer Science 2025-10-27 Gabriele Prato , Jerry Huang , Prasanna Parthasarathi , Shagun Sodhani , Sarath Chandar

While Large Language Models (LLMs) excel in world knowledge understanding, adapting them to specific subfields requires precise adjustments. Due to the model's vast scale, traditional global fine-tuning methods for large models can be…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Jiawei Chen , Yue Jiang , Dingkang Yang , Mingcheng Li , Jinjie Wei , Ziyun Qian , Lihua Zhang

Large Language Models (LLMs) need to adapt to the continuous changes in data, tasks, and user preferences. Due to their massive size and the high costs associated with training, LLMs are not suitable for frequent retraining. However,…

Computation and Language · Computer Science 2024-12-11 Dongfang Li , Zetian Sun , Xinshuo Hu , Baotian Hu , Min Zhang

While Large Language Models (LLMs) have demonstrated exceptional multitasking abilities, fine-tuning these models on downstream, domain-specific datasets is often necessary to yield superior performance on test sets compared to their…

Computation and Language · Computer Science 2024-03-15 Haoran Yang , Yumeng Zhang , Jiaqi Xu , Hongyuan Lu , Pheng Ann Heng , Wai Lam

Despite their outstanding performance, large language models (LLMs) suffer notorious flaws related to their preference for simple, surface-level textual relations over full semantic complexity of the problem. This proposal investigates a…

Computation and Language · Computer Science 2022-06-20 Michal Štefánik

Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of…

The increasing use of tools and solutions based on Large Language Models (LLMs) for various tasks in the medical domain has become a prominent trend. Their use in this highly critical and sensitive domain has thus raised important questions…

Computation and Language · Computer Science 2024-01-09 Jean-Baptiste Excoffier , Tom Roehr , Alexei Figueroa , Jens-Michalis Papaioannou , Keno Bressem , Matthieu Ortala

We aim to present a comprehensive overview of the latest advancements in utilizing Large Language Models (LLMs) within the healthcare sector, emphasizing their transformative impact across various medical domains. LLMs have become pivotal…

Computation and Language · Computer Science 2026-04-07 Ummara Mumtaz , Awais Ahmed , Summaya Mumtaz

Multimodal large language models (MLLMs) have shown remarkable capabilities in multimodal perception and understanding tasks. However, their effectiveness in specialized domains, such as remote sensing and medical imaging, remains limited.…

Computation and Language · Computer Science 2026-02-05 Qinglong Cao , Yuntian Chen , Chao Ma , Xiaokang Yang

Large Language Models (LLMs) internalize vast world knowledge as parametric memory, yet inevitably inherit the staleness and errors of their source corpora. Consequently, ensuring the reliability and malleability of these internal…

Computation and Language · Computer Science 2026-04-08 Xiaojie Gu , Ziying Huang , Weicong Hong , Jian Xie , Renze Lou , Kai Zhang

The recent success of large language models (LLMs) trained on static, pre-collected, general datasets has sparked numerous research directions and applications. One such direction addresses the non-trivial challenge of integrating…

Machine Learning · Computer Science 2024-11-26 Haizhou Shi , Zihao Xu , Hengyi Wang , Weiyi Qin , Wenyuan Wang , Yibin Wang , Zifeng Wang , Sayna Ebrahimi , Hao Wang

This paper investigates the challenges of developing large language models (LLMs) proficient in both multilingual understanding and medical knowledge. We demonstrate that simply translating medical data does not guarantee strong performance…

Computation and Language · Computer Science 2025-01-20 Nada Saadi , Tathagata Raha , Clément Christophe , Marco AF Pimentel , Ronnie Rajan , Praveen K Kanithi

This study aims to guide language model selection by investigating: 1) the necessity of finetuning versus zero-shot usage, 2) the benefits of domain-adjacent versus generic pretrained models, 3) the value of further domain-specific…

Computation and Language · Computer Science 2025-09-25 Lovedeep Gondara , Jonathan Simkin , Graham Sayle , Shebnum Devji , Gregory Arbour , Raymond Ng

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

Computers and Society · Computer Science 2025-11-07 Yusuf Yildiz , Goran Nenadic , Meghna Jani , David A. Jenkins

Large language models (LLMs) have been widely adopted in various downstream task domains. However, their abilities to directly recall and apply factual medical knowledge remains under-explored. Most existing medical QA benchmarks assess…

Computation and Language · Computer Science 2025-08-20 Jiaxi Li , Yiwei Wang , Kai Zhang , Yujun Cai , Bryan Hooi , Nanyun Peng , Kai-Wei Chang , Jin Lu

Large language models (LLMs) can store a vast amount of world knowledge, often extractable via question-answering (e.g., "What is Abraham Lincoln's birthday?"). However, do they answer such questions based on exposure to similar questions…

Computation and Language · Computer Science 2024-07-17 Zeyuan Allen-Zhu , Yuanzhi Li

Memorization in language models is typically treated as a homogenous phenomenon, neglecting the specifics of the memorized data. We instead model memorization as the effect of a set of complex factors that describe each sample and relate it…

Large language models (LLMs) have emerged as powerful tools with transformative potential across numerous domains, including healthcare and medicine. In the medical domain, LLMs hold promise for tasks ranging from clinical decision support…

Computation and Language · Computer Science 2024-05-14 Xiaolan Chen , Jiayang Xiang , Shanfu Lu , Yexin Liu , Mingguang He , Danli Shi
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